Zobrazeno 1 - 10
of 13
pro vyhledávání: '"IUPHAR Nomenclature Report"'
Autor:
Thomas L Williams, David J. Huggins, Petra Sulentic, Janet J. Maguire, Robyn Macrae, Cai Read, Duuamene Nyimanu, Peiran Yang, Robert C. Glen, Anthony P. Davenport
Publikováno v:
Pharmacological Reviews
The predicted protein encoded by the APJ gene discovered in 1993 was originally classified as a class A G protein-coupled orphan receptor but was subsequently paired with a novel peptide ligand, apelin-36 in 1998. Substantial research identified a fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e33aeb1af100558c125fd20a12e23d6
http://europepmc.org/articles/PMC6731456
http://europepmc.org/articles/PMC6731456
Autor:
Sarah C. R. Lummis, Alexander Roberts, Kathryn A. Cunningham, Carlos M. Villalón, Horst Vogel, Michael Camilleri, Carine Bécamel, Michael Gershon, Katharine Herrick-Davis, Trevor Sharp, Luc Maroteaux, Philippe Marin, Enza Lacivita, Bryan L. Roth, Stephanie W. Watts, Evelyn K. Lambe, Adam L. Halberstadt, Marcello Leopoldo, Daniel Hoyer, Anne Roumier, Milt Teitler, Severine Chaumont-Dubel, Gerard P. Ahern, Ruud Hovius, Adrian Newman-Tancredi, Gareth J. Sanger, Nathalie M. Goodfellow, Andrew C. McCreary, Giuseppe Di Giovanni, Sylvie Claeysen, John F. Neumaier, Finn Olav Levy, Nicholas M. Barnes, David Nelson, Kevin C. Fone, Joël Bockaert, Ghérici Hassaine, Rachel M. Hartley, Hugues Nury
Publikováno v:
Pharmacol Rev
Pharmacological Reviews
Pharmacological Reviews, American Society for Pharmacology and Experimental Therapeutics, 2020, 73 (1), pp.310-520. ⟨10.1124/pr.118.015552⟩
Pharmacological Reviews
Pharmacological Reviews, American Society for Pharmacology and Experimental Therapeutics, 2020, 73 (1), pp.310-520. ⟨10.1124/pr.118.015552⟩
5 HT receptors expressed throughout the human body are targets for established therapeutics and various drugs in development. Their diversity of structure and function reflects the important role 5-HT receptors play in physiologic and pathophysiologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf55e4383f6dbf6d09b590b20342f025
https://pubmed.ncbi.nlm.nih.gov/33370241
https://pubmed.ncbi.nlm.nih.gov/33370241
Autor:
Xavier, Norel, Yukihiko, Sugimoto, Gulsev, Ozen, Heba, Abdelazeem, Yasmine, Amgoud, Amel, Bouhadoun, Wesam, Bassiouni, Marie, Goepp, Salma, Mani, Hasanga D, Manikpurage, Amira, Senbel, Dan, Longrois, Akos, Heinemann, Chengcan, Yao, Lucie H, Clapp
Publikováno v:
Pharmacological Reviews
Prostaglandins are derived from arachidonic acid metabolism through cyclooxygenase activities. Among prostaglandins (PGs), prostacyclin (PGI2) and PGE2 are strongly involved in the regulation of homeostasis and main physiologic functions. In addition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8bbaf68b1f1ff003195ab9d849c868cc
https://pubmed.ncbi.nlm.nih.gov/32962984
https://pubmed.ncbi.nlm.nih.gov/32962984
Autor:
Marco Conti, Roland Seifert, Rennolds S. Ostrom, Carmen W. Dessauer, Val J. Watts, Stefan Dove
Publikováno v:
Pharmacological reviews, vol 69, iss 2
Adenylyl cyclases (ACs) generate the second messenger cAMP from ATP. Mammalian cells express nine transmembrane AC (mAC) isoforms (AC1-9) and a soluble AC (sAC, also referred to as AC10). This review will largely focus on mACs. mACs are activated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beada13274d5bcda497495ee2a0d98e6
https://doi.org/10.1124/pr.116.013078
https://doi.org/10.1124/pr.116.013078
Autor:
Hans-Jürgen Wester, Giovanni Tulipano, Zsolt Csaba, Justo P. Castaño, Stefan Schulz, Pascal Dournaud, Corinne Bousquet, Michael D. Culler, Hans-Jürgen Kreienkamp, Márta Korbonits, Thomas Günther, Shlomo Melmed, Amelie Lupp
Publikováno v:
Pharmacological Reviews
Somatostatin, also known as somatotropin-release inhibitory factor, is a cyclopeptide that exerts potent inhibitory actions on hormone secretion and neuronal excitability. Its physiologic functions are mediated by five G protein–coupled receptors (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a118d02a7fd2d2857d519c46edf2d63
https://hdl.handle.net/10668/12965
https://hdl.handle.net/10668/12965
Publikováno v:
Pharmacological Reviews
Chemerin, a chemoattractant protein and adipokine, has been identified as the endogenous ligand for a G protein–coupled receptor encoded by the gene CMKLR1 (also known as ChemR23), and as a consequence the receptor protein was renamed the chemerin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8f8ac4c4a5da219c9508ad1960e85a3f
https://pubmed.ncbi.nlm.nih.gov/29279348
https://pubmed.ncbi.nlm.nih.gov/29279348
Publikováno v:
Pharmacological Reviews. 64:1-15
Calcium-activated chloride channels (CaCCs) are widely expressed in various tissues and implicated in physiological processes such as sensory transduction, epithelial secretion, and smooth muscle contraction. Transmembrane proteins with unknown funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc7461eede61c24c3a4c62233872bc2
https://doi.org/10.1124/pr.111.005009
https://doi.org/10.1124/pr.111.005009
Publikováno v:
Pharmacological Reviews. 63:1-34
In the 10 years since our previous International Union of Basic and Clinical Pharmacology report on the nomenclature and classification of adenosine receptors, no developments have led to major changes in the recommendations. However, there have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a025035734330c267cc689a182eb49
https://doi.org/10.1124/pr.110.003285
https://doi.org/10.1124/pr.110.003285
Autor:
William A E Parker, Anthony P. Davenport, Tom I. Bonner, Steven M. Foord, Richard R. Neubig, Janet J. Maguire
Publikováno v:
Pharmacological Reviews. 61:1-8
Trace amines such as p-tyramine and beta-phenylethylamine are found endogenously as well as in the diet. Concomitant ingestion of these foodstuffs with monoamine oxidase inhibitors may result in the hypertensive crisis known as the "beer, wine, and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2864a116101e9ef1d78254ab65de2487
https://doi.org/10.1124/pr.109.001107
https://doi.org/10.1124/pr.109.001107
Autor:
Sadashiva S. Karnik, Walter G. Thomas, Kalyan C. Tirupula, Satoru Eguchi, Jacqueline R. Kemp, Hamiyet Unal, Patrick Vanderheyden
Publikováno v:
Pharmacological reviews. 67(4)
The renin angiotensin system (RAS) produced hormone peptides regulate many vital body functions. Dysfunctional signaling by receptors for RAS peptides leads to pathologic states. Nearly half of humanity today would likely benefit from modern drugs ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a49afdbbd7177404ffcf63812615388
https://pubmed.ncbi.nlm.nih.gov/26335847
https://pubmed.ncbi.nlm.nih.gov/26335847