Knockout of the SREBP system increases production of the polyketide FR901512 in filamentous fungal sp. No. 14919 and lovastatin in Aspergillus terreus ATCC20542.

Autor: Itoh, Hiroya^1,2 hiroya.ito@astellas.com, Miura, Ai³, Matsui, Makoto^1,2, Arazoe, Takayuki^2,4, Nishida, Keiji^2,5, Kumagai, Toshitaka⁶, Arita, Masanori^2,7, Tamano, Koichi³, Machida, Masayuki^2,3, Shibata, Takashi^1,2

Publikováno v: Applied Microbiology & Biotechnology. Feb2018, Vol. 102 Issue 3, p1393-1405. 13p.

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Genome Sequence of the Fungal Strain 14919 Producing 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibitor FR901512.

Autor: Itoh H; Biotechnology Labs, Astellas Pharma, Inc., Ibaraki, Japan hiroya.ito@astellas.com.; Technology Research Association of Highly Efficient Gene Design (TRAHED), Hokkaido, Japan., Matsui M; Biotechnology Labs, Astellas Pharma, Inc., Ibaraki, Japan.; Technology Research Association of Highly Efficient Gene Design (TRAHED), Hokkaido, Japan., Kumagai T; Technology Research Association of Highly Efficient Gene Design (TRAHED), Hokkaido, Japan.; Fermlab, Inc., Tokyo, Japan., Arita M; Technology Research Association of Highly Efficient Gene Design (TRAHED), Hokkaido, Japan.; National Institute of Genetics, Shizuoka, Japan., Machida M; Technology Research Association of Highly Efficient Gene Design (TRAHED), Hokkaido, Japan.; Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Sapporo, Hokkaido, Japan., Shibata T; Biotechnology Labs, Astellas Pharma, Inc., Ibaraki, Japan.; Technology Research Association of Highly Efficient Gene Design (TRAHED), Hokkaido, Japan.

Publikováno v: Genome announcements [Genome Announc] 2017 Apr 06; Vol. 5 (14). Date of Electronic Publication: 2017 Apr 06.