Zobrazeno 1 - 10
of 11
pro vyhledávání: '"ISO, isoprenaline"'
Publikováno v:
Acta Pharmaceutica Sinica. B
Rescuing cells from stress damage emerges a potential therapeutic strategy to combat myocardial infarction. Protocatechuic aldehyde (PCA) is a major phenolic acid in Chinese herb Danshen (Salvia miltiorrhiza root). This study investigated whether PCA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::56972065ff9bfb60fad239d339d0d883
https://pubmed.ncbi.nlm.nih.gov/34900536
https://pubmed.ncbi.nlm.nih.gov/34900536
Publikováno v:
Journal of Molecular and Cellular Cardiology
Ranieri, A, Kemp, E, Burgoyne, J R & Avkiran, M 2018, ' β-Adrenergic regulation of cardiac type 2A protein phosphatase through phosphorylation of regulatory subunit B56δ at S573 ', Journal of Molecular and Cellular Cardiology, vol. 115, pp. 20-31 . https://doi.org/10.1016/j.yjmcc.2017.12.016
Ranieri, A, Kemp, E, Burgoyne, J R & Avkiran, M 2018, ' β-Adrenergic regulation of cardiac type 2A protein phosphatase through phosphorylation of regulatory subunit B56δ at S573 ', Journal of Molecular and Cellular Cardiology, vol. 115, pp. 20-31 . https://doi.org/10.1016/j.yjmcc.2017.12.016
Background Type 2A protein phosphatase (PP2A) enzymes are serine/threonine phosphatases which comprise a scaffold A subunit, a regulatory B subunit and a catalytic C subunit, and have been implicated in the dephosphorylation of multiple cardiac phosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ea45c9b55a0793f176ac011e2d70a9e3
http://europepmc.org/articles/PMC5823843
http://europepmc.org/articles/PMC5823843
Autor:
Helen Budge, James Law, Hannah Scotney, Michael E. Symonds, Don Sharkey, Konstantinos N. Manolopoulos
Publikováno v:
Metabolism
© 2017 The Authors Introduction Brown adipose tissue (BAT) is a thermogenic organ with substantial metabolic capacity and has important roles in the maintenance of body weight and metabolism. Regulation of BAT is primarily mediated through the β-ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576a3ea2d6ce0eb57eeb1eff634c9bcc
https://doi.org/10.1016/j.metabol.2017.01.024
https://doi.org/10.1016/j.metabol.2017.01.024
Publikováno v:
EBioMedicine
EBioMedicine, Vol 18, Iss C, Pp 179-187 (2017)
EBioMedicine, Vol 18, Iss C, Pp 179-187 (2017)
Mitogen-activated protein kinases (MAPKs) and AMPactivated protein kinase α (AMPKα) play critical roles in the process of cardiac hypertrophy. Previous studies have demonstrated that piperine activates AMPKα and reduces the phosphorylation of ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ada4a8515da60f9e4b290d6176c8f4c
http://europepmc.org/articles/PMC5405163
http://europepmc.org/articles/PMC5405163
Publikováno v:
Puhl, S-L, Weeks, K L, Ranieri, A & Avkiran, M 2016, ' Assessing structural and functional responses of murine hearts to acute and sustained β-adrenergic stimulation in vivo ', Journal of pharmacological and toxicological methods, vol. 79, pp. 60-71 . https://doi.org/10.1016/j.vascn.2016.01.007
Journal of Pharmacological and Toxicological Methods
Journal of Pharmacological and Toxicological Methods
INTRODUCTION: Given the importance of β-adrenoceptor signalling in regulating cardiac structure and function, robust protocols are required to assess potential alterations in such regulation in murine models in vivo.METHODS: Echocardiography was per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9442035904ec982d8db032e314ef10e6
Publikováno v:
Redox Biology
Aims Ca2+/calmodulin-dependent protein kinase II (CaMKII) plays a critical role in the development of heart failure and in the induction of myocardial mitochondrial injury. Recent evidence has shown that hydrogen sulfide (H2S), produced by the enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a07e72b910e9be5736877c88627ac97a
https://pubmed.ncbi.nlm.nih.gov/30195191
https://pubmed.ncbi.nlm.nih.gov/30195191
Autor:
Tamara P. Martin, Maria P. Hortigon-Vinagre, George S. Baillie, Susan Currie, Christina Elliott, Jane E. Findlay
Publikováno v:
FEBS Open Bio
FEBS Open Bio, Vol 4, Iss C, Pp 923-927 (2014)
FEBS Open Bio, Vol 4, Iss C, Pp 923-927 (2014)
Highlights • A peptide was discovered that disrupts HSP20–phosphodiesterase 4D (PDE4D) complex formation. • HSP20–PDE4D complex disruption reversed hypertrophic-induced changes in electrical signalling in human cardiac myocytes. • HSP20–P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::975e82822068687572c6e546d0aca3ba
https://eprints.gla.ac.uk/99668/1/99668.pdf
https://eprints.gla.ac.uk/99668/1/99668.pdf
Autor:
Wayne Bond Lau, Yan Lee, Huishou Zhao, Kun Lian, Wenjun Yan, Xiyao Chen, Shihao Zhao, Wei Wang, Jinglong Zhang, Ling Zhang, Fuyang Zhang, Feng Yan, Cheng Peng, Ling Tao, Chao Gao, Yunlong Xia, Xin-Liang Ma
Publikováno v:
EBioMedicine, Vol 13, Iss C, Pp 157-167 (2016)
EBioMedicine
EBioMedicine
The Western meat-rich diet is both high in protein and fat. Although the hazardous effect of a high fat diet (HFD) upon liver structure and function is well recognized, whether the co-presence of high protein intake contributes to, or protects agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97ed5eb12a69790abfde563ef0de6601
Autor:
Zhang Y; Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Sun Yat-sen University, Guangzhou 510006, China., Ding Y; Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Sun Yat-sen University, Guangzhou 510006, China., Li M; Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Sun Yat-sen University, Guangzhou 510006, China., Yuan J; State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510006, China., Yu Y; State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510006, China., Bi X; Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Sun Yat-sen University, Guangzhou 510006, China., Hong H; Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Sun Yat-sen University, Guangzhou 510006, China., Ye J; Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Sun Yat-sen University, Guangzhou 510006, China., Liu P; Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Sun Yat-sen University, Guangzhou 510006, China.
Publikováno v:
Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2022 May; Vol. 12 (5), pp. 2374-2390. Date of Electronic Publication: 2021 Sep 25.
Autor:
Wu X; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China., Liu L; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China., Zheng Q; College of Pharmacy, China Pharmaceutical University, Nanjing 210009, China., Hao H; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.; College of Pharmacy, China Pharmaceutical University, Nanjing 210009, China., Ye H; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.; Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China., Li P; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China., Yang H; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Publikováno v:
Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2021 Nov; Vol. 11 (11), pp. 3553-3566. Date of Electronic Publication: 2021 Mar 13.