Zobrazeno 1 - 10
of 80
pro vyhledávání: '"ISMO MATTILA"'
Autor:
Christian S. Hansen, Tommi Suvitaival, Simone Theilade, Ismo Mattila, Maria Lajer, Kajetan Trošt, Linda Ahonen, Tine W. Hansen, Cristina Legido-Quigley, Peter Rossing, Tarunveer S. Ahluwalia
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
IntroductionDiabetic cardiovascular autonomic neuropathy (CAN) is associated with increased mortality and morbidity. To explore metabolic mechanisms associated with CAN we investigated associations between serum metabolites and CAN in persons with ty
Externí odkaz:
https://doaj.org/article/3a75b5a1a43443c2901590c44863a34f
Autor:
Andressa de Zawadzki, Maja Thiele, Tommi Suvitaival, Asger Wretlind, Min Kim, Mina Ali, Annette F. Bjerre, Karin Stahr, Ismo Mattila, Torben Hansen, Aleksander Krag, Cristina Legido-Quigley
Publikováno v:
Metabolites, Vol 12, Iss 3, p 211 (2022)
Feces are the product of our diets and have been linked to diseases of the gut, including Chron’s disease and metabolic diseases such as diabetes. For screening metabolites in heterogeneous samples such as feces, it is necessary to use fast and rep
Externí odkaz:
https://doaj.org/article/d216e48cb7884156878d17b3d73128b4
Autor:
Naba Al-Sari, Tommi Suvitaival, Ismo Mattila, Ashfaq Ali, Linda Ahonen, Kajetan Trost, Trine Foged Henriksen, Flemming Pociot, Lars Ove Dragsted, Cristina Legido-Quigley
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0228521 (2020)
Background and aimsAdipose tissue plays a pivotal role in storing excess fat and its composition reflects the history of person's lifestyle and metabolic health. Broad profiling of lipids with mass spectrometry has potential for uncovering new knowle
Externí odkaz:
https://doaj.org/article/4f63f5a119c3490b9cbc7fc235b9f0ea
Autor:
Matej Orešič, Jussi P. Posti, Maja H. Kamstrup-Nielsen, Riikka S.K. Takala, Hester F. Lingsma, Ismo Mattila, Sirkku Jäntti, Ari J. Katila, Keri L.H. Carpenter, Henna Ala-Seppälä, Anna Kyllönen, Henna-Riikka Maanpää, Jussi Tallus, Jonathan P. Coles, Iiro Heino, Janek Frantzén, Peter J. Hutchinson, David K. Menon, Olli Tenovuo, Tuulia Hyötyläinen
Publikováno v:
EBioMedicine, Vol 12, Iss C, Pp 118-126 (2016)
Traumatic brain injury (TBI) is a major cause of death and disability worldwide, especially in children and young adults. TBI is an example of a medical condition where there are still major lacks in diagnostics and outcome prediction. Here we apply
Externí odkaz:
https://doaj.org/article/7110dce9a4024de8863cdac90fb01489
Autor:
Tuulia Hyötyläinen, Livnat Jerby, Elina M. Petäjä, Ismo Mattila, Sirkku Jäntti, Petri Auvinen, Amalia Gastaldelli, Hannele Yki-Järvinen, Eytan Ruppin, Matej Orešič
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Non-alcoholic fatty liver disease (NAFLD) is a risk factor for other types of liver diseases. Here, the authors integrate transcriptomic and metabolomic data from patients with NAFLD with a genome-scale metabolic model to paint a comprehensive pictur
Externí odkaz:
https://doaj.org/article/6e1fc59352494a63bee5cc567082d455
Autor:
Matej Orešič, Gabriella Anderson, Ismo Mattila, Manoucher Manoucheri, Hilkka Soininen, Tuulia Hyötyläinen, Cherlynn Basignani
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2018)
Progression to AD is preceded by elevated levels of 2,4-dihydroxybutanoic acid (2,4-DHB), implicating hypoxia in early pathogenesis. Since hypoxia may play a role in multiple CNS disorders, we investigated serum metabolite profiles across three disor
Externí odkaz:
https://doaj.org/article/4ee9dacf376243d89c5fb429429c3bdd
Autor:
Maija-Liisa Mattinen, Karin Struijs, Tapani Suortti, Ismo Mattila, Kristiina Kruus, Stefan Willför, Tarja Tamminen, Jean-Paul Vincken
Publikováno v:
BioResources, Vol 4, Iss 2, Pp 482-496 (2009)
Oxidative polymerization of two isolated lignans, secoisolariciresinol, and secoisolariciresinol diglucoside, as well as the lignan macromolecule, by a high redox potential Trametes hirsuta laccase was studied with different analytical methods. The r
Externí odkaz:
https://doaj.org/article/9a85eac2e0c64081929c4644efebb3b9
Autor:
Marko Sysi-Aho, Andrey Ermolov, Peddinti V Gopalacharyulu, Abhishek Tripathi, Tuulikki Seppänen-Laakso, Johanna Maukonen, Ismo Mattila, Suvi T Ruohonen, Laura Vähätalo, Laxman Yetukuri, Taina Härkönen, Erno Lindfors, Janne Nikkilä, Jorma Ilonen, Olli Simell, Maria Saarela, Mikael Knip, Samuel Kaski, Eriika Savontaus, Matej Orešič
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 10, p e1002257 (2011)
Recent evidence from serum metabolomics indicates that specific metabolic disturbances precede β-cell autoimmunity in humans and can be used to identify those children who subsequently progress to type 1 diabetes. The mechanisms behind these disturb
Externí odkaz:
https://doaj.org/article/efa2394923bf45da8529c7eec04cc069
Autor:
Jose Juan Almagro Armenteros, Caroline Brorsson, Christian Holm Johansen, Karina Banasik, Gianluca Mazzoni, Robert Moulder, Karoliina Hirvonen, Tomi Suomi, Omid Rasool, Sylvaine FA Bruggraber, M Loredana Marcovecchio, Emile Hendricks, Naba Al-Sari, Ismo Mattila, Cristina Legido-Quigley, Tommi Suvitaival, Piotr J Chmura, Mikael Knip, Anke M Schulte, Jeong Heon Lee, Guido Sebastiani, Giuseppina Emanuela Grieco, Laura L Elo, Simranjeet Kaur, Flemming Pociot, Francesco Dotta, Tim Tree, Riitta Lahesmaa, Lut Overbergh, Chantal Mathieu, Mark Peakman, Søren Brunak
BackgroundHeterogeneity in the rate of β-cell loss in newly diagnosed type 1 diabetes patients is poorly understood and creates a barrier to designing and interpreting disease-modifying clinical trials. Integrative analyses of complementary multi-om
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1aed4945812f6d48199ab6c18d691d46
https://doi.org/10.1101/2023.03.22.23287261
https://doi.org/10.1101/2023.03.22.23287261
Autor:
NINNA H. TOUGAARD, MARIE FRIMODT-MOELLER, HANNE SALMENKARI, ELISABETH BUUR STOUGAARD, ISMO MATTILA, TINE W. HANSEN, CRISTINA LEGIDO-QUIGLEY, SOHVI HÖRKKÖ, CAROL FORSBLOM, PER-HENRIK GROOP, MARKKU LEHTO, PETER ROSSING
Publikováno v:
Diabetes. 71
Background: Fecal calprotectin, a marker of inflammation, is increased in persons with type 1 diabetes (T1D) and kidney disease. This may be explained by a reduction of butyrate-producing bacterial species in the gut. Butyrate supplementation has ben