Zobrazeno 1 - 10
of 70
pro vyhledávání: '"ISMAIL H. AL-ABDULLAH"'
Autor:
Hiroyuki Kato, Mayra Salgado, Daniel Mendez, Nelson Gonzalez, Jeffrey Rawson, Doreen Ligot, Bennie Balandran, Chris Orr, Janine C. Quijano, Keiko Omori, Meirigeng Qi, Ismail H. Al-Abdullah, Yoko Mullen, Hsun Teresa Ku, Fouad Kandeel, Hirotake Komatsu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Evaluating the quality of isolated human islets before transplantation is crucial for predicting the success in treating Type 1 diabetes. The current gold standard involves time-intensive in vivo transplantation into diabetic immunodeficient
Externí odkaz:
https://doaj.org/article/e4c92950caa44443bef83e5c39527a56
Autor:
Fatemeh Sabet Sarvestani, Ali-Mohammad Tamaddon, Mohammad-Hosein Karimi, Ramin Yaghoobi, Bita Geramizadeh, Mozhdeh Heydari, Ismail H. Al-Abdullah, Negar Azarpira
Publikováno v:
Pharmaceutical Sciences, Vol 29, Iss 1, Pp 90-99 (2023)
Background: Type 1 diabetes is an autoimmune disorder characterized by the loss of pancreatic islets. Islet allotransplantation is a potentially beneficial therapeutic approach for diabetes. Islets suffer a variety of cellular insults including ische
Externí odkaz:
https://doaj.org/article/46e02430e1674994be4aae266cb2b097
Autor:
Guihua Sun, Meirigeng Qi, Alexis S. Kim, Elizabeth M. Lizhar, Olivia W. Sun, Ismail H. Al-Abdullah, Arthur D. Riggs
Publikováno v:
Non-Coding RNA, Vol 9, Iss 2, p 20 (2023)
miRNAs are critical for pancreas development and function. However, we found that there are discrepancies regarding pancreatic miRNA abundance in published datasets. To obtain a more relevant profile that is closer to the true profile, we profiled sm
Externí odkaz:
https://doaj.org/article/01f635858bac481a8ad6d4e1bf975e09
Autor:
Fatemeh Sabet Sarvestani, Mohammad Ali Zare, Forough saki, Farhad Koohpeyma, Ismail H. al-Abdullah, Negar Azarpira
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 23, Iss 2, Pp 214-223 (2020)
Objective(s): Type 1 diabetes (T1D) is an autoimmune disease resulting from inflammatory destruction of islets β-cells. Nowadays, progress in cell therapy, especially mesenchymal stem cells (MSCs) proposes numerous potential remedies for T1D. We aim
Externí odkaz:
https://doaj.org/article/e6fe2e1c9f27485aa36fe3b19b2fdf23
Autor:
Hirotake Komatsu MD, PhD, Meirigeng Qi MD, PhD, Nelson Gonzalez, Mayra Salgado, Leonard Medrano, Jeffrey Rawson, Chris Orr PhD, Keiko Omori MD, PhD, Jeffrey S. Isenberg MD, MPH, Fouad Kandeel MD, PhD, Yoko Mullen MD, PhD, Ismail H. Al-Abdullah PhD
Publikováno v:
Cell Transplantation, Vol 30 (2021)
Prior to transplantation into individuals with type 1 diabetes, in vitro assays are used to evaluate the quality, function and survival of isolated human islets. In addition to the assessments of these parameters in islet, they can be evaluated by mu
Externí odkaz:
https://doaj.org/article/0f4ff8cb9b0b4e068b33d8fc6e8c5b57
Autor:
Keiko Omori, Ignacio Gonzalez, Cindy Nguyen, Shanti N. Raminani, Victor M. Deleon, Pedro Meza, Jose Zamalloa, Rachel G. Perez, Nelson Gonzalez, Hirotake Komatsu, Ismail H. Al-Abdullah, Xin Wen
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1584 (2022)
Hypothermic (cold) preservation is a limiting factor for successful cell and tissue transplantation where cell swelling (edema) usually develops, impairing cell function. University of Wisconsin (UW) solution, a standard cold preservation solution, c
Externí odkaz:
https://doaj.org/article/88e5dee383cb482084f32a27961b8136
Autor:
Bashar Khiatah, Meirigeng Qi, Weiting Du, Kuan T-Chen, Kayleigh M. van Megen, Rachel G. Perez, Jeffrey S. Isenberg, Fouad Kandeel, Bart O. Roep, Hsun Teresa Ku, Ismail H. Al-Abdullah
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-14 (2019)
Abstract Background Human pancreata contain many types of cells, such as endocrine islets, acinar, ductal, fat, and mesenchymal stromal cells (MSCs). MSCs are important and shown to have a promising therapeutic potential to treat various disease cond
Externí odkaz:
https://doaj.org/article/9fd3a5e3304b44408b415e66d8024491
Autor:
Somayeh Keshtkar, Maryam Kaviani, Zahra Jabbarpour, Bita Geramizadeh, Elahe Motevaseli, Saman Nikeghbalian, Alireza Shamsaeefar, Nasrin Motazedian, Ismail H. Al-Abdullah, Mohammad Hossein Ghahremani, Negar Azarpira
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Abstract Islets transplantation, as a treatment of type 1 diabetes, faces challenges, including the loss of islets in the process of isolation and pre-transplantation due to cellular stresses-induced apoptosis. Accordingly, the optimization of cultur
Externí odkaz:
https://doaj.org/article/8452747042f54cf090beddaab0c7fd41
Autor:
Bashar Khiatah, Meirigeng Qi, Youjun Wu, Kuan-Tsen Chen, Rachel Perez, Luis Valiente, Keiko Omori, Jeffrey S. Isenberg, Fouad Kandeel, Jiing-Kuan Yee, Ismail H. Al-Abdullah
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-6 (2019)
Abstract We developed an optimized Dipheylthiocarbazone or Dithizone (DTZ) with improved physical and chemical properties to characterize human islets and insulin-producing cells differentiated from embryonic stem cells. Application of the newly form
Externí odkaz:
https://doaj.org/article/78b909345c634e4cbdad967487951c3c
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 133, Iss , Pp 110944- (2021)
Ischemia reperfusion injury (IRI) is a condition that occurs wherever blood flow and oxygen is reduced or absent, such as trauma, vascular disease, stroke, and solid organ transplantation. This condition can lead to tissue damage, especially during o
Externí odkaz:
https://doaj.org/article/972caaa98c3a47f6bb16015c6d19be65