Zobrazeno 1 - 10
of 42
pro vyhledávání: '"IRS, insulin receptor substrate"'
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)
Diabetic nephropathy (DN) has been recognized as a severe complication of diabetes mellitus and a dominant pathogeny of end-stage kidney disease, which causes serious health problems and great financial burden to human society worldwide. Conventional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d8ab4193adc39b242fa3c089b4f517
https://doi.org/10.1016/j.apsb.2020.12.020
https://doi.org/10.1016/j.apsb.2020.12.020
Autor:
Pingping Luo, Rui Zhang, Qian Yu, George L. Tipoe, Ming Zheng, Xiaoming Sun, Yingxia Liu, Jia Xiao, Wei Li, Hong Zhang
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 668-679 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 668-679 (2021)
Alcoholic liver disease (ALD) causes insulin resistance, lipid metabolism dysfunction, and inflammation. We investigated the protective effects and direct regulating target of S-allylmercaptocysteine (SAMC) from aged garlic on liver cell injury. A ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f71348640a2921fa24860e2b42b33f51
http://europepmc.org/articles/PMC7982498
http://europepmc.org/articles/PMC7982498
Autor:
Paul M. Titchenell, Dominic Santoleri
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Insulin resistance is associated with numerous metabolic disorders, such as obesity and type II diabetes, that currently plague our society. Although insulin normally promotes anabolic metabolism in the liver by increasing glucose consumption and lip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c27eb16d2a993c3fec511936ebd4c8dd
https://doi.org/10.1016/j.jcmgh.2018.10.016
https://doi.org/10.1016/j.jcmgh.2018.10.016
Publikováno v:
The Journal of Biological Chemistry
Insulin-like growth factor (IGF) is a potent mitogen that activates the IGF receptor (IGFR)/insulin receptor substrate (IRS) axis, thus stimulating growth in normal cells and uncontrolled cell proliferation in cancer. Posttranslational modifications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db9f42ab7ea062e1b118be64301e157c
http://europepmc.org/articles/PMC8191236
http://europepmc.org/articles/PMC8191236
Autor:
Masanobu Morita, Yu Yamaguchi, Fumitoshi Irie, Yu Mei, Ai Shimane, Kazuhiko Yanai, Takeo Yoshikawa, Rina Otsuka, Takuro Matsuzawa
Publikováno v:
The Journal of Biological Chemistry
Heparan sulfate (HS), a highly sulfated linear polysaccharide, is involved in diverse biological functions in various tissues. Although previous studies have suggested a possible contribution of HS to the differentiation of white adipocytes, there ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e96a1800166fbc18d437ce1e6f65a7f4
https://pubmed.ncbi.nlm.nih.gov/34310946
https://pubmed.ncbi.nlm.nih.gov/34310946
Autor:
Raju V. S. Rajala
Publikováno v:
Journal of Lipid Research, Vol 62, Iss, Pp 100041-(2021)
Journal of Lipid Research
Journal of Lipid Research
The field of phosphoinositide signaling has expanded significantly in recent years. Phosphoinositides (also known as phosphatidylinositol phosphates or PIPs) are universal signaling molecules that directly interact with membrane proteins or with cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad76a0de070275a6dd0bb666e2b0f8c
http://www.sciencedirect.com/science/article/pii/S0022227521000213
http://www.sciencedirect.com/science/article/pii/S0022227521000213
Autor:
Roberta L. Beauchamp, Vijaya Ramesh, Justin T. Jordan, Serkan Erdin, Scott R. Plotkin, James F. Gusella, Luke Witt
Publikováno v:
The Journal of Biological Chemistry
Meningiomas (MNs), arising from the arachnoid/meningeal layer, are nonresponsive to chemotherapies, with ∼50% showing loss of the Neurofibromatosis 2 (NF2) tumor suppressor gene. Previously, we established NF2 loss activates mechanistic target of r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81cc1ada7a62b98c37a1556fc7d1099c
http://europepmc.org/articles/PMC7949095
http://europepmc.org/articles/PMC7949095
Autor:
Kamal D. Mehta, Xianlin Han, Vincenzo Coppola, Faizule Hassan, Kedryn K. Baskin, Michael C. Ostrowski, Yaoling Shu, Neil Mehta
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 44, Iss, Pp 101133-(2021)
Molecular Metabolism, Vol 44, Iss, Pp 101133-(2021)
Objective Nonalcoholic hepatic steatosis, also known as fatty liver, is a uniform response of the liver to hyperlipidic-hypercaloric diet intake. However, the post-ingestive signals and mechanistic processes driving hepatic steatosis are not well und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f37ab29dce39395a2e6ad5e16e59348a
http://europepmc.org/articles/PMC7785956
http://europepmc.org/articles/PMC7785956
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100031-(2021)
Journal of Lipid Research, Vol 62, Iss, Pp 100031-(2021)
Genetic variants that increase the risk of fatty liver disease and cirrhosis have recently been identified in the proximity of membrane-bound O-acyltransferase domain-containing 7 (MBOAT7). To elucidate the link between these variants and fatty liver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de5a14a108c211284d76c444098061be
https://pubmed.ncbi.nlm.nih.gov/32859645
https://pubmed.ncbi.nlm.nih.gov/32859645
Autor:
Tomomi Miyamoto, Eiki Takahashi, Ichiro Miyoshi, Natsuko Saito, Atsushi Asano, Yoshinori Shimamoto, Kohei Washio, Sanae Fukushima, Shunsuke Kimura, Chitoku Toda, Misato Amagasa, Hiroshi Kitamura, Chieko Nishioka, Shiki Okamoto
Publikováno v:
Biochemistry and Biophysics Reports, Vol 9, Iss C, Pp 322-329 (2017)
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports
We previously reported that ubiquitin-specific protease (USP) 2 in macrophages down-regulates genes associated with metabolic diseases, suggesting a putative anti-diabetic role for USP2 in macrophages. In this study, we evaluate this role at both cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db21366930bc0d7858ca686948953bfa
http://hdl.handle.net/10659/00005998
http://hdl.handle.net/10659/00005998