Zobrazeno 1 - 10
of 3 638
pro vyhledávání: '"IRF3"'
Autor:
Jianjun Feng, Xinwei Peng, Peng Lin, Yilei Wang, Ziping Zhang, Yuankai Xu, Pengfei Zou, Xiaojian Lai, Pengyun Chen, Tianyu Wang
Publikováno v:
Aquaculture and Fisheries, Vol 9, Iss 6, Pp 908-920 (2024)
IKKε is an IκB kinase participating in the control of NF-κB and type I IFN signal pathways in mammals. However, the function of IKKε in regulating immune response is largely unknown in teleost. Herein, an IKKε homologue named AjIKKε was charact
Externí odkaz:
https://doaj.org/article/e4c42fe394144d04b97d7ec7e84fddf7
Autor:
Radhika Joshi, Veronika Brezani, Gabrielle M. Mey, Sergi Guixé-Muntet, Marti Ortega-Ribera, Yuan Zhuang, Adam Zivny, Sebastian Werneburg, Jordi Gracia-Sancho, Gyongyi Szabo
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-22 (2024)
Abstract The pathological role of interferon signaling is emerging in neuroinflammatory disorders, yet, the specific role of Interferon Regulatory Factor 3 (IRF3) in neuroinflammation remains poorly understood. Here, we show that global IRF3 deficien
Externí odkaz:
https://doaj.org/article/a6777c870b7d4b4d97a8c4e5b7383a1a
Autor:
Xue Liang, Kunpeng Liu, Xin Jia, Cuiqin Cheng, Meiqi Zhang, Lingdong Kong, Qiqi Li, Zhe Liu, Min Li, Junliang Li, Yao Wang, Anlong Xu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 8, Pp 3513-3527 (2024)
Bile acids (BAs) are natural metabolites in mammals and have the potential to function as drugs against viral infection. However, the limited understanding of chenodeoxycholic acid (CDCA) receptors and downstream signaling, along with its lower suppr
Externí odkaz:
https://doaj.org/article/b8181f6001e84516a09bc978280c253e
Autor:
Muhammad Suleman, Abduh Murshed, Kashif Imran, Abbas Khan, Zafar Ali, Norah A. Albekairi, Dong-Qing Wei, Hadi M. Yassine, Sergio Crovella
Publikováno v:
BMC Chemistry, Vol 18, Iss 1, Pp 1-13 (2024)
Abstract The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to over six million deaths worldwide. In human immune system, the type 1 interferon (IFN) pathway plays a crucial role in fighting viral infections. However, the ORF8 protein of
Externí odkaz:
https://doaj.org/article/d7b019d7d78f4ee49ec445d873693c47
Autor:
Yiqiu Peng, Yuxi Yang, Yingying Li, Tingjuan Shi, Ning Xu, Ruixia Liu, Yingyi Luan, Yongming Yao, Chenghong Yin
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-26 (2024)
Abstract Background Macrophage proinflammatory activation contributes to the pathology of severe acute pancreatitis (SAP) and, simultaneously, macrophage functional changes, and increased pyroptosis/necrosis can further exacerbate the cellular immune
Externí odkaz:
https://doaj.org/article/b9e2bcff59c5482193ccd1470b3a53bc
Publikováno v:
Shanghai Jiaotong Daxue xuebao. Yixue ban, Vol 44, Iss 3, Pp 301-311 (2024)
Objective·To analyze the relationship between the expression level of interferon regulatory factor 3 (IRF3) in colorectal cancer and its clinicopathological features and prognosis, and to observe the effects of IRF3 overexpression on the proliferati
Externí odkaz:
https://doaj.org/article/1c1fe6d32aac4a4aaca33dd70ff94f6f
Autor:
Pengtao Jiao, Jianing Ma, Yuna Zhao, Xiaoxiao Jia, Haoran Zhang, Wenhui Fan, Xiaojuan Jia, Xiaoyuan Bai, Yiqi Zhao, Yongxu Lu, He Zhang, Jiayin Guo, Gang Pang, Ke Zhang, Min Fang, Minghua Li, Wenjun Liu, Geoffrey L. Smith, Lei Sun
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
The Orthopoxvirus (OPXV) genus of the Poxviridae includes human pathogens variola virus (VARV), monkeypox virus (MPXV), vaccinia virus (VACV), and a number of zoonotic viruses. A number of Bcl-2-like proteins of VACV are involved in escaping the host
Externí odkaz:
https://doaj.org/article/e39d1e875dcf4cadb8064dd29db4dc45
Autor:
Song Wang, Ran Wei, Xiaomei Ma, Jin Guo, Muhammad Aizaz, Fangxu Li, Jun Wang, Hongmei Wang, Hongbin He
Publikováno v:
Virulence, Vol 15, Iss 1 (2024)
ABSTRACTBovine viral diarrhoea-mucosal disease caused by bovine viral diarrhoea virus (BVDV) is a major infectious disease that affects the cattle industry. The nonstructural protein Npro of BVDV antagonizes the type I interferon (IFN-I) pathway, the
Externí odkaz:
https://doaj.org/article/4ccb08ebfdae492da658a9bfa511e7eb
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background Interferon Regulatory Factor 3 (IRF3) is a transcription factor that plays a crucial role in the innate immune response by recognizing and responding to foreign antigens. Recently, its roles in sterile conditions are being studied
Externí odkaz:
https://doaj.org/article/33090ef204054f3da42b26093e11c449
Autor:
Jincai Wen, Wenqing Mu, Hui Li, Yulu Yan, Xiaoyan Zhan, Wei Luo, Zhongxia Wang, Wen Kan, Jia Zhao, Siwen Hui, Ping He, Shuanglin Qin, Yingjie Xu, Ping Zhang, Xiaohe Xiao, Guang Xu, Zhaofang Bai
Publikováno v:
Molecular Medicine, Vol 29, Iss 1, Pp 1-13 (2023)
Abstract Background The cGAS-STING signaling pathway is an essential section of the natural immune system. In recent years, an increasing number of studies have shown a strong link between abnormal activation of the cGAS-STING signaling pathway, a na
Externí odkaz:
https://doaj.org/article/bdfcfe8f33bc4a3787977f006d991138