Zobrazeno 1 - 10 of 1 557 pro vyhledávání: '"IRE1 inositol-requiring enzyme 1"'
1
Akademický článek
Inhibition of the IRE1/JNK pathway in renal tubular epithelial cells attenuates ferroptosis in acute kidney injury
Autor: Yan Liang, Zhenjie Liu, Lingyun Qu, Yingzi Wang, Yali Zhou, Lulu Liang, Yanhong Guo, Lin Tang
Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)
Backgroud: Ferroptosis is a form of regulated cell death in ischemia-reperfusion (I/R) injury models. Acute kidney injury (AKI) induced by I/R injury can result in cell death, and subcellular structural changes, including expansion of the endoplasmic
Externí odkaz: https://doaj.org/article/d0a3ebab6fe04ccebda38df26524cd23
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2
Akademický článek
Mild Hyperthermia-Induced Thermogenesis in the Endoplasmic Reticulum Defines Stress Response Mechanisms.
Autor: Dukic, Barbara1,2 (AUTHOR) dukic.barbara@brc.hu, Ruppert, Zsófia1,3 (AUTHOR) vigh.laszlo@brc.hu, Tóth, Melinda E.1 (AUTHOR) gombos.imre@brc.hu, Hunya, Ákos1 (AUTHOR), Czibula, Ágnes4,5 (AUTHOR), Bíró, Péter6 (AUTHOR), Tiszlavicz, Ádám1 (AUTHOR), Péter, Mária1 (AUTHOR), Balogh, Gábor1 (AUTHOR), Erdélyi, Miklós6 (AUTHOR), Timinszky, Gyula4 (AUTHOR), Vígh, László1 (AUTHOR), Gombos, Imre1 (AUTHOR), Török, Zsolt1 (AUTHOR) torok.zsolt@brc.hu
Publikováno v: Cells (2073-4409). Jul2024, Vol. 13 Issue 13, p1141. 16p.
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3
Akademický článek
Structure and Molecular Mechanism of ER Stress Signaling by the Unfolded Protein Response Signal Activator IRE1
Autor: Christopher J. Adams, Megan C. Kopp, Natacha Larburu, Piotr R. Nowak, Maruf M. U. Ali
Publikováno v: Frontiers in Molecular Biosciences, Vol 6 (2019)
The endoplasmic reticulum (ER) is an important site for protein folding and maturation in eukaryotes. The cellular requirement to synthesize proteins within the ER is matched by its folding capacity. However, the physiological demands or aberrations
Externí odkaz: https://doaj.org/article/d27d807958cf4c4d93c2aa5d7a0255af
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4
Resensitising proteasome inhibitor-resistant myeloma with sphingosine kinase 2 inhibition
Autor: Briony L. Gliddon, Craig T. Wallington-Beddoe, Manjun Li, Darren J. Creek, Melissa R. Pitman, Melinda N. Tea, Paul Wang, Dovile Anderson, John Toubia, Melissa K. Bennett, Robert Z. Orlowski, Stuart M. Pitson, Jason A. Powell
Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 24, Iss 1, Pp 1-11 (2022)
Neoplasia (New York, N.Y.)
Refereed/Peer-reviewed The introduction of the proteasome inhibitor bortezomib into treatment regimens for myeloma has led to substantial improvement in patient survival. However, whilst bortezomib elicits initial responses in many myeloma patients,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4372e540234dd54ec39b9af964b760
http://www.sciencedirect.com/science/article/pii/S1476558621000993
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5
A cyclodextrin-based nanoformulation achieves co-delivery of ginsenoside Rg3 and quercetin for chemo-immunotherapy in colorectal cancer
Autor: Yun Dai, Zhuo Yu, Dandan Sun, Hao Yang, Liu Song, Shulan Han, Caitriona M. O'Driscoll, Jianfeng Guo, Di Chu, Jie Ma, Yifang Zou
Publikováno v: Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 378-393 (2022)
Acta Pharmaceutica Sinica. B
The immune checkpoint blockade therapy has profoundly revolutionized the field of cancer immunotherapy. However, despite great promise for a variety of cancers, the efficacy of immune checkpoint inhibitors is still low in colorectal cancer (CRC). Thi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee6dd4b7090c45d73c9ae54ee9fd9f2
http://www.sciencedirect.com/science/article/pii/S2211383521002173
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6
Temporal Transcript Profiling Identifies a Role for Unfolded Protein Stress in Human Gut Ischemia-Reperfusion Injury
Autor: Kaatje Lenaerts, Joep Grootjans, Anna M. Kip, Marco Manca, Steven W.M. Olde Damink, Bas Boonen, Cornelis H. C. Dejong, Wim A. Buurman, M'hamed Hadfoune, Joep P. M. Derikx, Erik A.L. Biessen
Publikováno v: CMGH, 13(3), 681-694. Elsevier Inc.
Cellular and Molecular Gastroenterology and Hepatology : CMGH 13(3), 681-694 (2022). doi:10.1016/j.jcmgh.2021.11.001
Cellular and molecular gastroenterology and hepatology, 13(3), 681-694. Elsevier Inc.
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Intestinal ischemia-reperfusion injury is a serious and life-threatening condition. A better understanding of molecular mechanisms related to intestinal ischemia-reperfusion injury in human beings is imperative to find therapeutic t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ba4ffc78867321b72f85db21a76d04
http://www.scopus.com/inward/record.url?scp=85121206348&partnerID=8YFLogxK
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7
Role of pyroptosis in spinal cord injury and its therapeutic implications
Autor: Chang Jia, Jian Xiao, Abdullah Al Mamun, Fahad Munir, Ilma Monalisa, Kailiang Zhou, Yanqing Wu
Publikováno v: Journal of Advanced Research, Vol 28, Iss, Pp 97-109 (2021)
Journal of Advanced Research
Graphical abstract
Highlights • Neuroinflammation plays a key role in the secondary injury of acute SCI. • Pyroptosis is defined as a newly programmed cell death. • Recent studies show that pyroptosis play a key role in SCI. • Some molec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58aaa585b7dc4e7f4e03b92a67b2a015
http://www.sciencedirect.com/science/article/pii/S2090123220301880
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8
The ER stress sensor inositol-requiring enzyme 1α in Kupffer cells promotes hepatic ischemia-reperfusion injury
Autor: Jie Cai, Xiaoge Zhang, Peng Chen, Yang Li, Songzi Liu, Qian Liu, Hanyong Zhang, Zhuyin Wu, Ke Song, Jianmiao Liu, Bo Shan, Yong Liu
Publikováno v: The Journal of Biological Chemistry
Hepatic ischemia/reperfusion (I/R) injury is an inflammation-mediated process arising from ischemia/reperfusion-elicited stress in multiple cell types, causing liver damage during surgical procedures and often resulting in liver failure. Endoplasmic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86338028f5113cd46609ec4ba5e153f
http://europepmc.org/articles/PMC8760522
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9
Akademický článek
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10
The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor
Autor: Vera Kovaleva, Richard Zimmermann, Mart Saarma, Maarit Hellman, Li-Ying Yu, Helka Göös, Päivi Lindholm, Perttu Permi, Ave Eesmaa, Kristofer Nõges, Martin Jung, Markku Varjosalo
Publikováno v: Journal of Biological Chemistry
The Journal of Biological Chemistry
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER)-stress-regulated protein exhibiting cytoprotective properties through a poorly understood mechanism in various in vitro and in vivo models of neuronal and non
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313ba32ad4a5ccd78db57615fd60c668
http://urn.fi/URN:NBN:fi:jyu-202102221722
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