The mammalian Ire1 inhibitor, 4µ8C, exhibits broad anti-Aspergillus activity in vitro and in a treatment model of fungal keratitis

Autor: Manali M. Kamath, Emily M. Adams, Jorge D. Lightfoot, Becca L. Wells, Kevin K. Fuller

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)

ObjectiveThe fungal unfolded protein response consists of a two-component relay in which the ER-bound sensor, IreA, splices and activates the mRNA of the transcription factor, HacA. Previously, we demonstrated that hacA is essential for Aspergillus f

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The mammalian Ire1 inhibitor, 4μ8C, exhibits broad anti- Aspergillus activity in vitro and in a treatment model of fungal keratitis.

Autor: Kamath MM; Department of Microbiology & Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK., Adams EM; Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK., Lightfoot JD; Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK., Wells BL; Department of Microbiology & Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK., Fuller KK; Department of Microbiology & Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK.; Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Aug 08. Date of Electronic Publication: 2024 Aug 08.