Zobrazeno 1 - 10
of 669
pro vyhledávání: '"IRE1α"'
Autor:
Yuzhou Xu, Feng Gui, Zhe Zhang, Zhongyang Chen, Tiange Zhang, Yunhan Hu, Huijun Wei, Yuchen Fu, Xinde Chen, Zhihao Wu
Publikováno v:
Thoracic Cancer, Vol 15, Iss 29, Pp 2116-2127 (2024)
Abstract Background Inositol‐requiring enzyme 1 (IRE1) is an endoplasmic reticulum (ER)‐resident transmembrane protein that senses ER stress and mediates an essential arm of the unfolded protein response (UPR). IRE1 reduces ER stress by upregulat
Externí odkaz:
https://doaj.org/article/f859a746fa45469598e66592e078d9f1
Publikováno v:
Redox Experimental Medicine, Vol 2024, Iss 1, Pp 1-11 (2024)
Objective: UV irradiation of the skin induces photo damage and generates cytotoxic intracellular reactive oxygen species (ROS), activating the unfolded protein response (UPR) to adapt or reduce these UVB-mediated damages. This study was designed to u
Externí odkaz:
https://doaj.org/article/1b4e1667bf3f4e41b2ae80403c8f373a
Autor:
Hui Luo, Wen-Yan Gong, Yuan-Yuan Zhang, Ying-Ying Liu, Zhen Chen, Xing-Lin Feng, Qi-Bin Jiao, Xing-Wei Zhang
Publikováno v:
Heliyon, Vol 10, Iss 21, Pp e39011- (2024)
Inositol-requiring enzyme 1 (IRE1), a mediator of the unfolded protein response, shows the highest degree of evolutionary conservation. Vertebrates express two IRE1 paralogs: IRE1α, which is universally expressed and IRE1β, which shows specific exp
Externí odkaz:
https://doaj.org/article/c68c0fbc8ae641648ebcd63843143366
Publikováno v:
BMC Oral Health, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Backgroud Hypoadiponectinemia is the important cause of insulin resistance. Recent studies have shown that periodontitis is associated with hypoadiponectinemia. The purpose of this study was to investigate the effect of periodontitis-induced
Externí odkaz:
https://doaj.org/article/2b79d60af2a04bd9bd924a21d750bac8
Autor:
Wang Liu, Chenchen He, Changlin Li, Shazhou Ye, Jiang Zhao, Cunle Zhu, Xiangwei Wang, Qi Ma, Benyi Li
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: Alternol is a small molecular compound isolated from the fermentation of a mutant fungus obtained from Taxus brevifolia bark. Our previous studies showed that Alternol treatment induced reactive oxygen species (ROS)-dependent immunogenic
Externí odkaz:
https://doaj.org/article/babc2f0e41b3491593532361575b2ac5
Autor:
Guihong Shi, Liang Liu, Yiyao Cao, Guangshuo Ma, Yanlin Zhu, Jianye Xu, Xu Zhang, Tuo Li, Liang Mi, Haoran Jia, Yanfeng Zhang, Xilei Liu, Yuan Zhou, Shenghui Li, Guili Yang, Xiao Liu, Fanglian Chen, Baolong Wang, Quanjun Deng, Shu Zhang, Jianning Zhang
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-28 (2023)
Abstract Background Neuroinflammation is one of the most important pathogeneses in secondary brain injury after traumatic brain injury (TBI). Neutrophil extracellular traps (NETs) forming neutrophils were found throughout the brain tissue of TBI pati
Externí odkaz:
https://doaj.org/article/fd6f2db45e0b4fd99d70f58164c57d20
Autor:
Song Zhao, Haiping Feng, Dongfang Jiang, Keyan Yang, Si-Tong Wang, Yu-Xin Zhang, Yun Wang, Hongmei Liu, Caixia Guo, Tie-Shan Tang
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Background Maintaining homeostasis of Ca2+ stores in the endoplasmic reticulum (ER) is crucial for proper Ca2+ signaling and key cellular functions. Although Ca2+ depletion has been known to cause ER stress which in turn activates the unfold
Externí odkaz:
https://doaj.org/article/e075de67c82447b2801262f3c770be72
Autor:
Gaëlle Mawambo, Malika Oubaha, Yusuke Ichiyama, Guillaume Blot, Sergio Crespo-Garcia, Agnieszka Dejda, François Binet, Roberto Diaz-Marin, Christina Sawchyn, Mikhail Sergeev, Rachel Juneau, Randal J. Kaufman, El Bachir Affar, Frédérick A. Mallette, Ariel M. Wilson, Przemyslaw Sapieha
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-14 (2023)
Abstract Cellular adaptation to low oxygen tension triggers primitive pathways that ensure proper cell function. Conditions of hypoxia and low glucose are characteristic of injured tissues and hence successive waves of inflammatory cells must be suit
Externí odkaz:
https://doaj.org/article/43e12a5532544c0686ece219c67a0571
Autor:
Xiaoye Qu, Tao Yang, Xiao Wang, Dongwei Xu, Yeping Yu, Jun Li, Longfeng Jiang, Qiang Xia, Douglas G. Farmer, Bibo Ke
Publikováno v:
JHEP Reports, Vol 5, Iss 11, Pp 100879- (2023)
Background & Aims: Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) is a central player in triggering necroptotic cell death. However, whether macrophage RIPK3 may regulate NOD1-dependent inflammation and calcineurin/transient receptor
Externí odkaz:
https://doaj.org/article/ff345f1706304f7a9531be654746bcd1
Autor:
Jiangwei Xiao, Jingwen Huang, Xiaoting Jian, Han Wang, Haiqiang Lan, Zhaohong Liao, Ruicai Gu, Jijie Hu, Hua Liao
Publikováno v:
Cellular & Molecular Biology Letters, Vol 28, Iss 1, Pp 1-24 (2023)
Abstract Endoplasmic reticulum stress (ERS) and the unfolded protein response (UPR) are involved in various muscle pathological states. The IRE1α arm of UPR can affect immunological properties of myofiber through restraining p38 mitogen-activated pr
Externí odkaz:
https://doaj.org/article/1b2e96402bd1464cba52a9d63cf7477a