Zobrazeno 1 - 10
of 911
pro vyhledávání: '"IRAK4"'
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 4, Pp 2946-2960 (2024)
Targeting the FLT3 receptor and the IL-1R associated kinase 4 as well as the anti-apoptotic proteins MCL1 and BCL2 may be a promising novel approach in the treatment of acute myeloid leukemia (AML). The FLT3 and IRAK4 inhibitor emavusertib (CA4948),
Externí odkaz:
https://doaj.org/article/ab41290b58f549f1851ded0efc64d10f
Autor:
Guillermo Garcia-Manero, Uwe Platzbecker, Kian-Huat Lim, Grzegorz Nowakowski, Omar Abdel-Wahab, Hagop Kantarjian, Amit Verma, Daniel T. Starczynowski
Publikováno v:
Frontiers in Hematology, Vol 3 (2024)
The intracellular serine/threonine interleukin 1 receptor-associated kinase 4 (IRAK4) is necessary for most signaling by activated Toll-like receptors (TLRs). Activation of IRAK4 drives activation of nuclear factor kappa B (NF-κB) and so promotes ce
Externí odkaz:
https://doaj.org/article/636932ab680b4146a8c5950be2b3129a
Autor:
Christian T. Wohnhaas, Kevin Baßler, Carolin K. Watson, Yang Shen, Germán G. Leparc, Cornelia Tilp, Fabian Heinemann, David Kind, Birgit Stierstorfer, Denis Delić, Thomas Brunner, Florian Gantner, Joachim L. Schultze, Coralie Viollet, Patrick Baum
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Smoking is a leading risk factor of chronic obstructive pulmonary disease (COPD), that is characterized by chronic lung inflammation, tissue remodeling and emphysema. Although inflammation is critical to COPD pathogenesis, the cellular and molecular
Externí odkaz:
https://doaj.org/article/63c91076861d42e1acc8a8990681ade0
Autor:
Shuxi Qiao, Brianna LaViolette, Brianna LaCarubba Paulhus, Xiangping Li, John Litchfield, Zhenhong Li, John C. Stansfield, Richard L. Gieseck III, Bei B. Zhang, Danna M. Breen
Publikováno v:
JCSM Rapid Communications, Vol 6, Iss 2, Pp 122-133 (2023)
Abstract Background Inflammation is a hallmark of cachexia; however, effective anti‐inflammatory treatments have not yet been identified. Interleukin‐1 receptor‐associated kinase 4 (IRAK4) is a key signalling node linking interleukin‐1 recept
Externí odkaz:
https://doaj.org/article/e431d4d801b04a6dae39ebe825e67012
Akademický článek
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Autor:
Yuqing Huang, Yi Ning, Zhiwei Chen, Peiran Song, Haotian Tang, Wenhao Shi, Zhipeng Wan, Gege Huang, Qiupei Liu, Yun Chen, Yu Zhou, Yuantong Li, Zhengsheng Zhan, Jian Ding, Wenhu Duan, Hua Xie
Publikováno v:
Molecules, Vol 29, Iss 8, p 1803 (2024)
IRAK4 is a critical mediator in NF-κB-regulated inflammatory signaling and has emerged as a promising therapeutic target for the treatment of autoimmune diseases; however, none of its inhibitors have received FDA approval. In this study, we identifi
Externí odkaz:
https://doaj.org/article/39a037e6b43f47df940acb637c8cc434
Publikováno v:
BMC Oral Health, Vol 23, Iss 1, Pp 1-17 (2023)
Abstract Background The biomaterial integration depends on its interaction with the host immune system. Monocyte-macrophage lineage cells are immediately recruited to the implant site, polarized into different phenotypes, and fused into multinucleate
Externí odkaz:
https://doaj.org/article/5eb27fb0bae64a5f922ff16aea263e10
Autor:
Sae-Bom Yoon, Hyowon Hong, Hee-Jong Lim, Ji Hye Choi, Yoon Pyo Choi, Seong Wook Seo, Hyuk Woo Lee, Chong Hak Chae, Woo-Kyu Park, Hyun Young Kim, Daeyoung Jeong, Tran Quang De, Chang-Seon Myung, Heeyeong Cho
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 3, Pp 1093-1109 (2023)
Interleukin-1 receptor-associated kinase 4 (IRAK4) is a pivotal enzyme in the Toll-like receptor (TLR)/MYD88 dependent signaling pathway, which is highly activated in rheumatoid arthritis tissues and activated B cell-like diffuse large B-cell lymphom
Externí odkaz:
https://doaj.org/article/06e3ac574c0849ed8c4b61044cdc2a36
Autor:
Parvin Khalilian, Nahid Eskandari, Mohammad Jafar Sharifi, Mohammad Soltani, Pardis Nematollahi
Publikováno v:
Advanced Biomedical Research, Vol 13, Iss 1, Pp 17-17 (2024)
Background: Myelodysplastic syndrome (MDS) is a clonal hematologic disorder that requires the integration of morphologic, cytogenetic, hematologic, and clinical findings for a successful diagnosis. Trying to find ancillary tests such as biomarkers im
Externí odkaz:
https://doaj.org/article/eab9f506f57f47bf85d56365ed3c97eb
Akademický článek
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