Zobrazeno 1 - 9
of 9
pro vyhledávání: '"IR, ionising radiation"'
Autor:
Shikang Liang, Tom L. Blundell, Amanda K. Chaplin, Aleš Hnízda, Antonia Kefala Stavridi, Robert Appleby
Publikováno v:
Progress in Biophysics and Molecular Biology
Non-homologous end joining (NHEJ) is the preferred pathway for the repair of DNA double-strand breaks in humans. Here we describe three structural aspects of the repair pathway: stages, scaffolds and strings. We discuss the orchestration of DNA repai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca43e6e448ffae277c09ed2c9f19bd34
https://www.repository.cam.ac.uk/handle/1810/316479
https://www.repository.cam.ac.uk/handle/1810/316479
Autor:
Alexander Hergovich, Angeliki Ditsiou, Juan Jose Garcia-Gomez, Fumiko Esashi, Ramazan Gundogdu, Valenti Gomez, Victoria J. Spanswick, M. Kadir Erdogan, John A. Hartley
Publikováno v:
Cellular Signalling
Monopolar spindle-one binder (MOBs) proteins are evolutionarily conserved and contribute to various cellular signalling pathways. Recently, we reported that hMOB2 functions in preventing the accumulation of endogenous DNA damage and a subsequent p53/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::781e7f8fa05bb5c2814bf41145d35d64
https://aperta.ulakbim.gov.tr/record/232808
https://aperta.ulakbim.gov.tr/record/232808
Autor:
Edyta Heropolitanska Pliszka, Małgorzata Pac, Mateusz Maciejczyk, Bożena Mikołuć, Barbara Pietrucha, Halina Car, Radosław Motkowski
Publikováno v:
Redox Biology, Vol 11, Iss, Pp 375-383 (2017)
Redox Biology
Redox Biology
Rare pleiotropic genetic disorders, Ataxia-telangiectasia (A-T), Bloom syndrome (BS) and Nijmegen breakage syndrome (NBS) are characterised by immunodeficiency, extreme radiosensitivity, higher cancer susceptibility, premature aging, neurodegeneratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67542494f0fd02567e8cbe6a4d847ca2
Publikováno v:
DNA Repair
DNA-protein crosslinks (DPCs) are a specific type of DNA lesion consisting of a protein covalently and irreversibly bound to DNA, which arise after exposure to physical and chemical crosslinking agents. DPCs can be bulky and thereby pose a barrier to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3e5438d87ad1b1061b50aef98e3fe56a
https://doi.org/10.1016/j.dnarep.2018.08.025
https://doi.org/10.1016/j.dnarep.2018.08.025
Publikováno v:
Mutation Research
Exposure to ionising radiation can lead to an increased risk of cancer, particularly leukaemia. In radiation-induced acute myeloid leukaemia (rAML), a partial hemizygous deletion of mouse chromosome 2 is a common feature in several susceptible strain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ff371543b2f9b58c8abec333735cb1
Publikováno v:
British Journal of Cancer
Germline mutations in both BRCA2 and CHEK2 are associated with an increased risk for male breast cancer. To search for potential interactions between the products of these breast cancer susceptibility genes, we undertook systematic mapping of BRCA2 f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa6783b677bab2b309298ebfad388ca9
https://doi.org/10.1038/sj.bjc.6604644
https://doi.org/10.1038/sj.bjc.6604644
Akademický článek
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Publikováno v:
FEBS Open Bio
Under normal conditions histone H2AX is constitutively phosphorylated on tyrosine (Y) 142 by Williams–Beuren syndrome transcription factor kinase (WSTF). Following DNA double strand breaks (DSB), Y142 is de-phosphorylated and serine (S) 139 is phos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb989a19ea9ccbd760b5c227b816bb94
Autor:
Brown JA; Genome Stability Laboratory, Centre for Chromosome Biology, School of Natural Sciences, National University of Ireland, Galway, Galway, Ireland., Eykelenboom JK, Lowndes NF
Publikováno v:
FEBS open bio [FEBS Open Bio] 2012 Sep 29; Vol. 2, pp. 313-7. Date of Electronic Publication: 2012 Sep 29 (Print Publication: 2012).