Isoform- and Paralog-Switching in IR-Signaling: When Diabetes Opens the Gates to Cancer

Autor: Pierluigi Scalia, Antonio Giordano, Caroline Martini, Stephen J. Williams

Publikováno v: Biomolecules, Vol 10, Iss 12, p 1617 (2020)

Insulin receptor (IR) and IR-related signaling defects have been shown to trigger insulin-resistance in insulin-dependent cells and ultimately to give rise to type 2 diabetes in mammalian organisms. IR expression is ubiquitous in mammalian tissues, a

Externí odkaz: https://doaj.org/article/37706b4388a6470081611b4772020034

Hormonal Contribution to Liver Regeneration

Autor: Wei Zhou, Anan Abu Rmilah, Scott L. Nyberg

Publikováno v: Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 4, Iss 3, Pp 315-338 (2020)
Mayo Clinic Proceedings: Innovations, Quality & Outcomes

An understanding of the molecular basis of liver regeneration will open new horizons for the development of novel therapies for chronic liver failure. Such therapies would solve the drawbacks associated with liver transplant, including the shortage o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57f94c2b2aed8589dc105db85be58c0
http://www.sciencedirect.com/science/article/pii/S2542454820300394

Specific knockout of p85α in brown adipose tissue induces resistance to high-fat diet–induced obesity and its metabolic complications in male mice

Autor: Patrik Majewski, Giorgio Sesti, Almudena Gómez-Hernández, Manuel Benito, Silvia Fernandez, Vanesa Viana-Huete, Carlota Rubio-Longas, Oscar Escribano, Nuria Beneit, Andrea R. López-Pastor, Marta Letizia Hribal, Gema García-Gómez

Publikováno v: Molecular Metabolism, Vol 31, Iss, Pp 1-13 (2020)
Molecular Metabolism

Objective An increase in mass and/or brown adipose tissue (BAT) functionality leads to an increase in energy expenditure, which may be beneficial for the prevention and treatment of obesity. Moreover, distinct class I PI3K isoforms can participate in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba95c1f433092b02d8345ccbfe40f6ea
https://doi.org/10.1016/j.molmet.2019.10.010

The aminosterol Claramine inhibits β-secretase 1–mediated insulin receptor cleavage

Autor: Bénédicte, Gaborit, Roland, Govers, Alexandre, Altié, Jean Michel, Brunel, Pierre, Morange, Franck, Peiretti

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 297 (1), pp.100818. ⟨10.1016/j.jbc.2021.100818⟩
Journal of Biological Chemistry, 2021, 297 (1), pp.100818. ⟨10.1016/j.jbc.2021.100818⟩
The Journal of Biological Chemistry

International audience; The cleavage of the insulin receptor by β-secretase 1 (BACE1) in the liver increases during diabetes, which contributes to reduce insulin receptor levels and impair insulin signaling. However, the precise signaling events tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d438b123de19467c77e8e9b4739301bb
https://hal.archives-ouvertes.fr/hal-03368302

Phospholipid exchange shows insulin receptor activity is supported by both the propensity to form wide bilayers and ordered raft domains

Autor: W. Todd Miller, Pavana Suresh, Erwin London

Publikováno v: The Journal of Biological Chemistry

Insulin receptor (IR) is a membrane tyrosine kinase that mediates the response of cells to insulin. IR activity has been shown to be modulated by changes in plasma membrane lipid composition, but the properties and structural determinants of lipids m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e9b0557f035e23db17055d331c8f26
https://pubmed.ncbi.nlm.nih.gov/34324831