Zobrazeno 1 - 10
of 65
pro vyhledávání: '"IR, Insulin receptor"'
Publikováno v:
Biomolecules, Vol 10, Iss 12, p 1617 (2020)
Insulin receptor (IR) and IR-related signaling defects have been shown to trigger insulin-resistance in insulin-dependent cells and ultimately to give rise to type 2 diabetes in mammalian organisms. IR expression is ubiquitous in mammalian tissues, a
Externí odkaz:
https://doaj.org/article/37706b4388a6470081611b4772020034
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)
Diabetic nephropathy (DN) has been recognized as a severe complication of diabetes mellitus and a dominant pathogeny of end-stage kidney disease, which causes serious health problems and great financial burden to human society worldwide. Conventional
Publikováno v:
Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 4, Iss 3, Pp 315-338 (2020)
Mayo Clinic Proceedings: Innovations, Quality & Outcomes
Mayo Clinic Proceedings: Innovations, Quality & Outcomes
An understanding of the molecular basis of liver regeneration will open new horizons for the development of novel therapies for chronic liver failure. Such therapies would solve the drawbacks associated with liver transplant, including the shortage o
Publikováno v:
Saudi Journal of Biological Sciences, Vol 27, Iss 2, Pp 736-750 (2020)
Saudi Journal of Biological Sciences
Saudi Journal of Biological Sciences
The incidence of Alzheimer’s disease (AD) has risen exponentially worldwide over the past decade. A growing body of research indicates that AD is linked to diabetes mellitus (DM) and suggests that impaired insulin signaling acts as a crucial risk f
Autor:
Patrik Majewski, Giorgio Sesti, Almudena Gómez-Hernández, Manuel Benito, Silvia Fernandez, Vanesa Viana-Huete, Carlota Rubio-Longas, Oscar Escribano, Nuria Beneit, Andrea R. López-Pastor, Marta Letizia Hribal, Gema García-Gómez
Publikováno v:
Molecular Metabolism, Vol 31, Iss, Pp 1-13 (2020)
Molecular Metabolism
Molecular Metabolism
Objective An increase in mass and/or brown adipose tissue (BAT) functionality leads to an increase in energy expenditure, which may be beneficial for the prevention and treatment of obesity. Moreover, distinct class I PI3K isoforms can participate in
Publikováno v:
Journal of Ginseng Research
Journal of Ginseng Research, Vol 45, Iss 1, Pp 86-97 (2021)
Journal of Ginseng Research, Vol 45, Iss 1, Pp 86-97 (2021)
Background Panax ginseng Meyer has been used as a nourishing edible herb in East Asia for thousands of years. 25-OH-PPT was first discovered as a natural rare triterpenoid saponin in ginseng stems and leaves by our group. Research found that it showe
Autor:
Nicolás Varas, Deepak Chatterjee, Yen-Shan Chen, Mark A. Jarosinski, Michael A. Weiss, Balamurugan Dhayalan
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 52, Iss, Pp 101325-(2021)
Molecular Metabolism, Vol 52, Iss, Pp 101325-(2021)
Background The discovery of insulin in 1921 and its near-immediate clinical use initiated a century of innovation. Advances extended across a broad front, from the stabilization of animal insulin formulations to the frontiers of synthetic peptide che
Autor:
Bénédicte, Gaborit, Roland, Govers, Alexandre, Altié, Jean Michel, Brunel, Pierre, Morange, Franck, Peiretti
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 297 (1), pp.100818. ⟨10.1016/j.jbc.2021.100818⟩
Journal of Biological Chemistry, 2021, 297 (1), pp.100818. ⟨10.1016/j.jbc.2021.100818⟩
The Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 297 (1), pp.100818. ⟨10.1016/j.jbc.2021.100818⟩
Journal of Biological Chemistry, 2021, 297 (1), pp.100818. ⟨10.1016/j.jbc.2021.100818⟩
The Journal of Biological Chemistry
International audience; The cleavage of the insulin receptor by β-secretase 1 (BACE1) in the liver increases during diabetes, which contributes to reduce insulin receptor levels and impair insulin signaling. However, the precise signaling events tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d438b123de19467c77e8e9b4739301bb
https://hal.archives-ouvertes.fr/hal-03368302
https://hal.archives-ouvertes.fr/hal-03368302
Publikováno v:
The Journal of Biological Chemistry
Insulin receptor (IR) is a membrane tyrosine kinase that mediates the response of cells to insulin. IR activity has been shown to be modulated by changes in plasma membrane lipid composition, but the properties and structural determinants of lipids m
Publikováno v:
Biochimie Open, Vol 7, Iss, Pp 26-32 (2018)
Biochimie Open
Biochimie Open
Vanadate, a protein tyrosine phosphatase inhibitor which elicits insulin-like effects, has previously been shown to inhibit expression of the insulin receptor gene at the transcriptional level in rat hepatoma cells. In an attempt to identify the DNA