Zobrazeno 1 - 10
of 25
pro vyhledávání: '"IPSC, inhibitory postsynaptic current"'
Autor:
Hiroshi Yamada, Ryo Taiji, Shunji Tsutsui, Terumasa Nakatsuka, Naoko Nishio, Wataru Taniguchi, Manabu Yamanaka
Publikováno v:
Biochemistry and Biophysics Reports, Vol 28, Iss, Pp 101130-(2021)
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports
Riluzole (2-amino-6-(trifluoromethoxy)benzothiazole) is a drug known for its inhibitory effect on glutamatergic transmission and its anti-nociceptive and anti-allodynic effects in neuropathic pain rat models. Riluzole also has an enhancing effect on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8d3549535d30d1ec684d846de041289
http://www.sciencedirect.com/science/article/pii/S2405580821002247
http://www.sciencedirect.com/science/article/pii/S2405580821002247
Publikováno v:
IBRO Neuroscience Reports
Long-term cannabis use during adolescence has deleterious effects in brain that are largely ascribed to the activation of cannabinoid-1 receptors (CB1Rs) by delta-9-tetrahydrocannabinol (∆9-THC), the primary psychoactive compound in marijuana. Syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b03004304b8098b3141dcd72323ca6f0
https://pubmed.ncbi.nlm.nih.gov/34667972
https://pubmed.ncbi.nlm.nih.gov/34667972
Publikováno v:
Neurobiology of Stress, Vol 9, Iss, Pp 113-123 (2018)
Neurobiology of Stress
Neurobiology of Stress
Erythropoietin (EPO) has been shown to improve cognitive function in mammals as well as in patients of psychiatric diseases by directly acting on the brain. In addition, EPO attenuates the synaptic transmission and enhances short- and long-term synap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1af9391ae432b32e55a29984804c00e4
https://doi.org/10.1016/j.ynstr.2018.08.008
https://doi.org/10.1016/j.ynstr.2018.08.008
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 5, Iss 3, Pp 198-209 (2016)
Molecular Metabolism, Vol 5, Iss 3, Pp 198-209 (2016)
Objective Humans and animals exposed to undernutrition (UN) during development often experience accelerated “catch-up” growth when food supplies are plentiful. Little is known about the mechanisms regulating early growth rates. We previously repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cde45139f1e374a007d5fe077f7baa7
Publikováno v:
Molecular Metabolism, Vol 36, Iss, Pp-(2020)
Molecular Metabolism
Molecular Metabolism
Objective Orexin (ORX) and melanin-concentrating hormone (MCH) neurons in the lateral hypothalamus are critical regulators of energy homeostasis and are thought to differentially contribute to diet-induced obesity. However, it is unclear whether the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ddd8fc2a52b921da0778c6ba3e515a
https://doi.org/10.1016/j.molmet.2020.100977
https://doi.org/10.1016/j.molmet.2020.100977
Autor:
Laurence Coutellier, Chloe E. Page
Publikováno v:
EBioMedicine
An imbalance between neuronal excitation and inhibition represents a core feature in multiple neuropsychiatry disorders, necessitating the development of novel strategies to calibrate the excitatory–inhibitory balance of therapeutics. Here we ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30783fd33ba25b45c6dcfb9509bac92a
http://europepmc.org/articles/PMC6161475
http://europepmc.org/articles/PMC6161475
Autor:
Zhiping P. Pang, Weiping Han
Publikováno v:
Bioscience Reports
Bioscience Reports, Vol 32, Iss 5 (2012)
Bioscience Reports, Vol 32, Iss 5 (2012)
Energy homoeostasis, a co-ordinated balance of food intake and energy expenditure, is regulated by the CNS (central nervous system). The past decade has witnessed significant advances in our understanding of metabolic processes and brain circuitry wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6131da5879a901fc01ad40e624a2bb4a
http://europepmc.org/articles/PMC3804927
http://europepmc.org/articles/PMC3804927
Autor:
Erika Polgár, Andrew J. Todd
Publikováno v:
Neuroscience
Although there is evidence that reduced inhibition in the spinal dorsal horn contributes to neuropathic pain, the mechanisms that underlie this are poorly understood. We have previously demonstrated that there is no loss of neurons from laminae I-III
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0b77c5442a0675639564e86f87bc2a9
Autor:
Véronique M. André, Michael Levine, Carlos Cepeda, Carlos A Thomas, Soong Ho Kim, Michelle E. Ehrlich, Damian M. Cummings
Publikováno v:
ASN NEURO
ASN Neuro, Vol 3 (2011)
ASN Neuro, Vol 3 (2011)
HD (Huntington's disease) is characterized by dysfunction and death of striatal MSNs (medium-sized spiny neurons). Excitotoxicity, transcriptional dysregulation and mitochondrial abnormalities are among the mechanisms that are proposed to play roles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b3078c01867e4b95b32ad4112565dc
http://europepmc.org/articles/PMC3155197
http://europepmc.org/articles/PMC3155197
Publikováno v:
ASN NEURO
ASN Neuro, Vol 2 (2010)
ASN Neuro, Vol 2 (2010)
Since the identification of the gene responsible for HD (Huntington's disease), many genetic mouse models have been generated. Each employs a unique approach for delivery of the mutated gene and has a different CAG repeat length and background strain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e228e6c5986a2c6c436a8355cd6659d
http://europepmc.org/articles/PMC2888168
http://europepmc.org/articles/PMC2888168