MAVS signaling shapes microglia responses to neurotropic virus infection

Autor: Olivia Luise Gern, Andreas Pavlou, Felix Mulenge, Lena Mareike Busker, Luca Ghita, Angela Aringo, Bibiana Costa, Julia Spanier, Inken Waltl, Martin Stangel, Ulrich Kalinke

Publikováno v: Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-20 (2024)

Abstract Viral encephalitis is characterized by a series of immunological reactions that can control virus infection in the brain, but dysregulated responses may cause excessive inflammation and brain damage. Microglia are brain-resident myeloid cell

Externí odkaz: https://doaj.org/article/3a4b81cf883c496bbc455a39ca77bc0f

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Swine acute diarrhea syndrome coronavirus (SADS-CoV) antagonizes interferon-β production via blocking IPS-1 and RIG-I

Autor: Zhihai Zhou, Jingyun Ma, Tian Lan, Yao-Rong Tan, Li Qianniu, Xiaoling Yan, Yuan Sun, Xiaoyu Tang

Publikováno v: Virus Research

Highlights • SADS-CoV failed to induce IFN-β expression and inhibited poly (I:C)-or SEV-mediated IFN-β production in IPEC-J2 cells. • SADS-CoV interrupted poly (I:C)-induced phosphorylation and nuclear translocation of IRF3 and NF-κB. • SADS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86806a2d8f0a277bd992f173c0fe45f7
https://doi.org/10.1016/j.virusres.2019.197843

Up-regulation of RIP1 and IPS-1 in chronic HBV infected patients

Autor: Mohammad Kazemi Arababadi, Minoo Safari-Arababadi, Mohammad Hossein Modarressi

Publikováno v: Genetics and Molecular Biology, Issue: ahead, Published: 19 AUG 2019
Genetics and Molecular Biology, Volume: 42, Issue: 2, Pages: 337-343, Published: 19 AUG 2019
Genetics and Molecular Biology, Vol 42, Iss 2, Pp 337-343
Genetics and Molecular Biology v.42 n.2 2019
Genetics and Molecular Biology
Sociedade Brasileira de Genética (SBG)
instacron:SBG

IPS-1 and RIP1 are the main downstream molecules of RIG1 and MDA5, as intracytoplasmic receptors, which are the main receptors involved in recognition of internal and external viral double-stranded RNA. In this project, mRNA levels of IPS-1 and RIP1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4081f1a7a98fb16f4b6fd07b9221ccbd
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019005035101&lng=en&tlng=en