Zobrazeno 1 - 10
of 75
pro vyhledávání: '"IPA, ingenuity pathway analysis"'
Autor:
David T. Dicker, Avital Lev, Amriti R. Lulla, Nagib Ahsan, Xiaobing Tian, Philip Abbosh, Shengliang Zhang, Wafik S. El-Deiry
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 3, Pp 304-325 (2021)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
A long-term goal in the cancer-field has been to develop strategies for treating p53-mutated tumors. A novel small-molecule, PG3-Oc, restores p53 pathway-signaling in tumor cells with mutant-p53, independently of p53/p73. PG3-Oc partially upregulates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d419892791cbc639df5b005d4a370b
https://doi.org/10.1016/j.neo.2021.01.004
https://doi.org/10.1016/j.neo.2021.01.004
Autor:
Bernard L. Schneider, Rashmi Kothary, Maica Llavero-Hurtado, Thomas H. Gillingwater, Abdelmadjid Atrih, Alexandra Tierney, Jean Michaud, Ariane Beauvais, Thomas M. Wishart, Lucia Chehade, Marc-Olivier Deguise, Douglas J. Lamont, Simon H. Parson, Yves De Repentigny, Mary-Ellen Harper, Chantal A. Pileggi
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 354-377.e3 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Deguise, M-O, Pileggi, C, De Repentigny, Y, Beauvais, A, Tierney, A, Chehade, L, Michaud, J, Llavero hurtado, M, Lamont, D, Atrih, A, Wishart, T, Gillingwater, T, Schneider, B L, Harper, M-E, Parson, S & Kothary, R 2021, ' SMN depleted mice offer a robust and rapid onset model of non-alcoholic fatty liver disease ', Cellular and Molecular Gastroenterology and Hepatology . https://doi.org/10.1016/j.jcmgh.2021.01.019
Cellular and Molecular Gastroenterology and Hepatology
Deguise, M-O, Pileggi, C, De Repentigny, Y, Beauvais, A, Tierney, A, Chehade, L, Michaud, J, Llavero hurtado, M, Lamont, D, Atrih, A, Wishart, T, Gillingwater, T, Schneider, B L, Harper, M-E, Parson, S & Kothary, R 2021, ' SMN depleted mice offer a robust and rapid onset model of non-alcoholic fatty liver disease ', Cellular and Molecular Gastroenterology and Hepatology . https://doi.org/10.1016/j.jcmgh.2021.01.019
Background & Aims Nonalcoholic fatty liver disease (NAFLD) is considered a health epidemic with potential devastating effects on the patients and the healthcare systems. Current preclinical models of NAFLD are invariably imperfect and generally take
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7a717cf593f4034226b292cb0ee07cc
http://www.sciencedirect.com/science/article/pii/S2352345X21000254
http://www.sciencedirect.com/science/article/pii/S2352345X21000254
Autor:
Stuti Khadka, Kylie N. Peterson, Sara R. Druffner, Lecong Zhou, John A. Cidlowski, Jonathan T. Busada, Deborah J. Stumpo, Robert H. Oakley, Perry J. Blackshear
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1831-1845 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Aberrant immune activation is associated with numerous inflammatory and autoimmune diseases and contributes to cancer development and progression. Within the stomach, inflammation drives a well-established sequence from gastritis to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::babfa03bf005f616576f6a9b0dedb7a9
http://www.sciencedirect.com/science/article/pii/S2352345X21001612
http://www.sciencedirect.com/science/article/pii/S2352345X21001612
Autor:
Chi Hou Ng, Mu Shiun Tsai, Mai Huong Thi Nguyen, Jean Lu, Ming Hong Chen, Shu Chen Liu, Nianhan Ma, Long Yuan Li, Jen Chieh Tsai, Chen Huan Lin, Hironobu Ihn, Hsuan Lin, Satoshi Fukushima, Azusa Miyashita, In Yu Lin, Szu Mam Liu
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 12, Pp 789-799 (2020)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
BRAF inhibitors were approved for the treatment of BRAF-mutant melanoma. However, most patients acquire the resistance to BRAF inhibitors after several months of treatment. miR-524-5p is considered as a tumor suppressor in many cancers, including mel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34d1c07ad9f7bf3140c025ea38a8d55
http://www.sciencedirect.com/science/article/pii/S1476558620301640
http://www.sciencedirect.com/science/article/pii/S1476558620301640
Publikováno v:
Toxicology Reports
Toxicology Reports, Vol 7, Iss, Pp 805-815 (2020)
Toxicology Reports, Vol 7, Iss, Pp 805-815 (2020)
MicroRNAs (miRNAs) are short non-coding RNA species that play key roles in post-transcriptional regulation of gene expression. MiRNAs also serve as a promising source of early biomarkers for different environmental exposures and health effects, altho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ed6501d212ec2b41bf3e7600201d9f
https://doi.org/10.1016/j.toxrep.2020.06.006
https://doi.org/10.1016/j.toxrep.2020.06.006
Autor:
Johanna McChord, Katharina Ganss, Christian Krautz, Sebastian Hempel, Klaus-Peter Knoch, Michele Solimena, Robert Grützmann, Philippe Ravassard, Kamal Chowdhury, Jürgen Weitz, Stephan Kersting, Christian Pilarsky, Hassan Mziaut, Steffen Wolk, Georg Henniger
Publikováno v:
Molecular metabolism
Molecular metabolism, Elsevier, 2020, 31, pp.150-162. ⟨10.1016/j.molmet.2019.11.012⟩
Molecular Metabolism, Vol 31, Iss, Pp 150-162 (2020)
Molecular Metabolism
Mol. Metab. 31, 150-162 (2020)
Molecular metabolism, Elsevier, 2020, 31, pp.150-162. ⟨10.1016/j.molmet.2019.11.012⟩
Molecular Metabolism, Vol 31, Iss, Pp 150-162 (2020)
Molecular Metabolism
Mol. Metab. 31, 150-162 (2020)
Objective MicroRNAs (miRNAs) play an integral role in maintaining beta cell function and identity. Deciphering their targets and precise role, however, remains challenging. In this study, we aimed to identify miRNAs and their downstream targets invol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac233ce670f178447662777e657c669
https://doi.org/10.1016/j.molmet.2019.11.012
https://doi.org/10.1016/j.molmet.2019.11.012
Autor:
Sander Meisner, Agnès Ribeiro, Vanesa Muncan, Manon E. Wildenberg, Jarom Heijmans, Christine Jones, Jan Koster, Gijs R. van den Brink, Jacqueline L.M. Vermeulen, Jonathan H. M. van der Meer, François Boudreau, Paula S. Montenegro-Miranda
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 209-223 (2020)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, 10(2), 209-223. Elsevier Inc.
Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, 10(2), 209-223. Elsevier Inc.
Background & Aims Recent evidence has suggested that the intact intestinal epithelial barrier protects our body from a range of immune-mediated diseases. The epithelial layer has an impressive ability to reconstitute and repair upon damage and this p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5f98bd5feac0564f9b5ecfa8b528cf
http://www.sciencedirect.com/science/article/pii/S2352345X20300345
http://www.sciencedirect.com/science/article/pii/S2352345X20300345
Publikováno v:
Molecular & Cellular Proteomics : MCP
Drug resistance is a critical obstacle to effective treatment in patients with chronic myeloid leukemia. To understand the underlying resistance mechanisms in response to imatinib mesylate (IMA) and adriamycin (ADR), the parental K562 cells were trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3bdf625e96948f348e1492f9567a2e8
http://europepmc.org/articles/PMC8800142
http://europepmc.org/articles/PMC8800142
Autor:
Sarina Kajani, Sean Curley, Marcella E. O'Reilly, Xiaofei Yin, Eugene T. Dillon, Weili Guo, Kanishka N. Nilaweera, Lorraine Brennan, Helen M. Roche, Fiona C. McGillicuddy
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 56, Iss, Pp 101425-(2022)
Molecular Metabolism, Vol 56, Iss, Pp 101425-(2022)
Introduction High-fat diet (HFD)-induced obesity impairs clearance of cholesterol through the Reverse Cholesterol Transport (RCT) pathway, with downregulation in hepatic expression of cholesterol and bile acid transporters, namely ABCG5/8 and ABCB11,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd64a6ca0d0d390204b0035129b8ef9
http://europepmc.org/articles/PMC8762459
http://europepmc.org/articles/PMC8762459
Autor:
Karl J. Wahlin, Jun Wan, Ravi Chakra Turaga, Cynthia A. Berlinicke, Jiang Qian, Joseph L. Mertz, Melissa M. Liu, Ming-Wen Hu, Donald J. Zack, Srinivasa R. Sripathi, Julien Maruotti
Publikováno v:
Molecular & Cellular Proteomics : MCP
Stress and injury to the retinal pigment epithelium (RPE) often lead to dedifferentiation and epithelial-to-mesenchymal transition (EMT). These processes have been implicated in several retinal diseases, including proliferative vitreoretinopathy, dia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f434ce93c2c1575dac4028fd9af5368
http://europepmc.org/articles/PMC8482521
http://europepmc.org/articles/PMC8482521