Výsledky vyhledávání - "IP3, inositol triphosphate"

Signaling roles of phosphoinositides in the retina

Autor: Raju V. S. Rajala

Publikováno v: Journal of Lipid Research, Vol 62, Iss, Pp 100041-(2021)
Journal of Lipid Research

The field of phosphoinositide signaling has expanded significantly in recent years. Phosphoinositides (also known as phosphatidylinositol phosphates or PIPs) are universal signaling molecules that directly interact with membrane proteins or with cyto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad76a0de070275a6dd0bb666e2b0f8c
http://www.sciencedirect.com/science/article/pii/S0022227521000213

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Optogenetic control of small GTPases reveals RhoA mediates intracellular calcium signaling

Autor: Hironori Inaba, Takao Nakata, Qianqian Miao

Publikováno v: The Journal of Biological Chemistry

Rho/Ras family small GTPases are known to regulate numerous cellular processes, including cytoskeletal reorganization, cell proliferation, and cell differentiation. These processes are also controlled by Ca2+, and consequently, cross talk between the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::140bda14014405287b83abe6cfc634b1
http://europepmc.org/articles/PMC7949103

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Ugonin U stimulates NLRP3 inflammasome activation and enhances inflammasome-mediated pathogen clearance

Autor: Wen-Yi Chang, Yung-Fong Tsai, Chun-Yu Chen, Chih-Chuang Liaw, Tsong-Long Hwang, Chuan-Hui Yang

Publikováno v: Redox Biology, Vol 11, Iss, Pp 263-274 (2017)
Redox Biology

The NOD-like receptor pyrin domain 3 (NLRP3) inflammasome contains Nod-like receptors, a subclass of pattern recognition receptors, suggesting that this complex has a prominent role in host defenses. Various structurally diverse stimulators activate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e06f83fe436ec59015422cdf4d6291e4
http://www.sciencedirect.com/science/article/pii/S2213231716303500

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Resveratrol derivatives increase cytosolic calcium by inhibiting plasma membrane ATPase and inducing calcium release from the endoplasmic reticulum in prostate cancer cells

Autor: Colton M. Crowther, Merritt B. Andrus, Joshua Allen Peterson, Jason Kenealey

Publikováno v: Biochemistry and Biophysics Reports, Vol 19, Iss, Pp-(2019)
Biochemistry and Biophysics Reports

Resveratrol (RES) is a putative chemotherapeutic naturally found in grapes, peanuts, and Japanese knotweed. Previous studies demonstrate that RES modulates calcium signaling as part of its chemotherapeutic activity. In this study, we determined the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb8e35920497016e21ff9426031dd74
http://www.sciencedirect.com/science/article/pii/S2405580819300652

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Disrupted endothelial cell heterogeneity and network organization impair vascular function in prediabetic obesity

Autor: Charlotte Buckley, Calum Wilson, Matthew D. Lee, Helen R. Heathcote, Nasser M Alorfi, Margaret MacDonald, Xun Zhang, Sharon Dolan, John G. McCarron

Publikováno v: Metabolism

Background Obesity is a major risk factor for diabetes and cardiovascular diseases such as hypertension, heart failure, and stroke. Impaired endothelial function occurs in the earliest stages of obesity and underlies vascular alterations that give ri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c7335dbb86f3e5a503faa5a51dc672a
https://doi.org/10.1016/j.metabol.2020.154340

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Brain stem adenosine receptors modulate centrally mediated hypotensive responses in conscious rats: A review

Autor: Abdel A. Abdel-Rahman, Noha N. Nassar

Publikováno v: Journal of Advanced Research, Vol 6, Iss 3, Pp 331-340 (2015)
Journal of Advanced Research

Graphical abstract
Adenosine is implicated in the modulation of cardiovascular responses either at the peripheral or at central level in experimental animals. However, there are no dedicated reviews on the involvement of adenosine in mediating t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff5c61fab1f959f8412cca6ea976732a
http://www.sciencedirect.com/science/article/pii/S2090123214001520

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Immunoreceptors on neutrophils

Autor: Hanke L. Matlung, Katka Szilagyi, Taco W. Kuijpers, Timo K. van den Berg, Dieke J van Rees

Publikováno v: van Rees, D J, Szilagyi, K, Kuijpers, T W, Matlung, H L & van den Berg, T K 2016, ' Immunoreceptors on neutrophils ', Seminars in immunology, vol. 28, no. 2, pp. 94-108 . https://doi.org/10.1016/j.smim.2016.02.004
Seminars in Immunology
Seminars in immunology, 28(2), 94-108. Academic Press Inc.

Highlights • Neutrophil activities must be tightly controlled to maintain immune homeostasis. • Activating and inhibitory receptors balance the outcome of immune cell activation. • Immunoreceptors contain Ig-like extracellular domains and signa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498f6a028ffa967d55b1919325120864
https://research.vumc.nl/en/publications/08d2d945-819c-4fe2-8ba4-abf1bff0994e

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Picornavirus inhibitors

Autor: Luis Carrasco

Publikováno v: Pharmacology & Therapeutics

Picornaviruses are among the best understood animal viruses in molecular terms. A number of important human and animal pathogens are members of the Picornaviridae family. The genome organization, the different steps of picornavirus growth and numerou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::751625b60573a1d7548d2933e274653c
https://pubmed.ncbi.nlm.nih.gov/7533301

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