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pro vyhledávání: '"IP(3) receptor"'
Akademický článek
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Autor:
Ana M. Rossi, Andrew M. Riley, Colin W. Taylor, Taufiq Rahman, Barry V. L. Potter, Geneviève Dupont
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109932-(2021)
Cell Reports
Cell Reports
Summary Inositol 1,4,5-trisphosphate receptors (IP3Rs) are intracellular Ca2+ channels that link extracellular stimuli to Ca2+ signals. Ca2+ release from intracellular stores is “quantal”: low IP3 concentrations rapidly release a fraction of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::736722494650aa7d895e81ababb6b67b
https://ora.ox.ac.uk/objects/uuid:783f4d6d-0ebb-4780-a849-6882b4946f44
https://ora.ox.ac.uk/objects/uuid:783f4d6d-0ebb-4780-a849-6882b4946f44
Autor:
Ian Parker, Jeffrey T. Lock
We previously described that cell-wide cytosolic Ca2+ transients evoked by inositol trisphosphate (IP3) are generated by two modes of Ca2+ liberation from the ER; ‘punctate’ release via an initial flurry of transient Ca2+ puffs from local cluster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81fd5647c2404d265b426b09b72b1e0d
https://escholarship.org/uc/item/1079w5bq
https://escholarship.org/uc/item/1079w5bq
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1877:188791
Members of the Bcl-2-protein family are key controllers of apoptotic cell death. The family is divided into antiapoptotic (including Bcl-2 itself, Bcl-xL, Mcl-1, etc.) and proapoptotic members (Bax, Bak, Bim, Bim, Puma, Noxa, Bad, etc.). These protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4200074a16f0bc46ef5c52c4ac2dec0a
https://doi.org/10.1016/j.bbcan.2022.188791
https://doi.org/10.1016/j.bbcan.2022.188791
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1866:1092-1100
Inositol 1,4,5-trisphosphate receptors (IP3R) are the most widely expressed intracellular Ca2+ release channels. Their activation by IP3 and Ca2+ allows Ca2+ to pass rapidly from the ER lumen to the cytosol. The resulting increase in cytosolic [Ca2+]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d38a13bf603e16fa80cb4db9794ddc5
https://doi.org/10.1016/j.bbamcr.2018.11.007
https://doi.org/10.1016/j.bbamcr.2018.11.007
Autor:
Brailoiu, Eugen, Chakraborty, Sumita, Brailoiu, G Cristina, Zhao, Pingwei, Barr, Jeffrey L, Ilies, Marc A, Unterwald, Ellen M, Abood, Mary E, Taylor, Colin W
Publikováno v:
Cell Reports, Vol 26, Iss 2, Pp 330-337.e4 (2019)
Summary: Sigma-1 receptors (Sig-1Rs) are integral ER membrane proteins. They bind diverse ligands, including psychoactive drugs, and regulate many signaling proteins, including the inositol 1,4,5-trisphosphate receptors (IP3Rs) that release Ca2+ from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c0b7aabda95439518d2eee8854e49d
http://www.sciencedirect.com/science/article/pii/S2211124718319818
http://www.sciencedirect.com/science/article/pii/S2211124718319818
Inside cells, the endoplasmic reticulum (ER) forms the largest Ca2+ store. Ca2+ is actively pumped by the SERCA pumps in the ER, where intraluminal Ca2+-binding proteins enable the accumulation of large amount of Ca2+. IP3 receptors and the ryanodine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c958f3e153734b91680b68229eafe757
https://lirias.kuleuven.be/handle/123456789/673792
https://lirias.kuleuven.be/handle/123456789/673792
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108483-(2020)
Summary: The mitotic spindle distributes chromosomes evenly to daughter cells during mitosis. The orientation of the spindle, guided by internal and external cues, determines the axis of cell division and thereby contributes to tissue morphogenesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2426afa3650ddbcd2a1a5e4f6935e6ab
http://www.sciencedirect.com/science/article/pii/S2211124720314728
http://www.sciencedirect.com/science/article/pii/S2211124720314728
Autor:
Andrew R. Lavik, Karen S. McColl, Fernanda O. Lemos, Martijn Kerkhofs, Fei Zhong, Michael Harr, Daniela Schlatzer, Kozo Hamada, Katsuhiko Mikoshiba, Francesco Crea, Geert Bultynck, Martin D. Bootman, Jan B. Parys, Clark W. Distelhorst
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1869:119206
Pyruvate kinase isoform M2 (PKM2) is a rate-limiting glycolytic enzyme that is widely expressed in embryonic tissues. The expression of PKM2 declines in some tissues following embryogenesis, while other pyruvate kinase isozymes are upregulated. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79297f172d870149cd2aa4c6e6492530
https://doi.org/10.1016/j.bbamcr.2021.119206
https://doi.org/10.1016/j.bbamcr.2021.119206