Výsledky vyhledávání - "IOVINO, Flora"

Akademický článek

RNAi mediated acute depletion of Retinoblastoma protein (pRb) promotes aneuploidy in human primary cells via micronuclei formation

Autor: Iovino Flora, Schillaci Tiziana, Lentini Laura, Amato Angela, Di Leonardo Aldo

Publikováno v: BMC Cell Biology, Vol 10, Iss 1, p 79 (2009)

Abstract Background Changes in chromosome number or structure as well as supernumerary centrosomes and multipolar mitoses are commonly observed in human tumors. Thus, centrosome amplification and mitotic checkpoint dysfunctions are believed possible

Externí odkaz: https://doaj.org/article/3074ec328d9b40f7aa4af95d9723df56

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Akademický článek

RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts

Autor: Amato Angela, Lentini Laura, Iovino Flora, Di Leonardo Aldo

Publikováno v: Molecular Cancer, Vol 5, Iss 1, p 38 (2006)

Abstract Background Incorrect segregation of whole chromosomes or parts of chromosome leads to aneuploidy commonly observed in cancer. The correct centrosome duplication, assuring assembly of a bipolar mitotic spindle, is essential for chromosome seg

Externí odkaz: https://doaj.org/article/a64e28142aae4af79382c1e245be0b4b

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