Zobrazeno 1 - 10
of 7 979
pro vyhledávání: '"INTERIM ANALYSIS"'
Publikováno v:
Expert Review of Vaccines, Vol 23, Iss 1, Pp 523-534 (2024)
Background Traditional vaccine development, often a lengthy and costly process of three separated phases. However, the swift development of COVID-19 vaccines highlighted the critical importance of accelerating the approval of vaccines. This article s
Externí odkaz:
https://doaj.org/article/a84114249ebe4724a6672df5029c9fbd
Autor:
Neuhäuser, Markus, author, Ruxton, Graeme D., author
Publikováno v:
The Statistical Analysis of Small Data Sets, 2024, ill.
Externí odkaz:
https://doi.org/10.1093/oso/9780198872979.003.0008
Publikováno v:
Diagnostic and Prognostic Research, Vol 8, Iss 1, Pp 1-12 (2024)
Abstract Interim analysis is a common methodology in randomised clinical trials but has received less attention in studies of diagnostic test accuracy. In such studies, early termination for futility may be beneficial if early evidence indicates that
Externí odkaz:
https://doaj.org/article/0ce239033da045939363d2a7507abf82
Publikováno v:
BMC Medical Research Methodology, Vol 23, Iss 1, Pp 1-17 (2023)
Abstract Background Adaptive clinical trials are growing in popularity as they are more flexible, efficient and ethical than traditional fixed designs. However, notwithstanding their increased use in assessing treatments for COVID-19, their use in cr
Externí odkaz:
https://doaj.org/article/2121345ca3f942baa56f86e93690e591
Autor:
Jufen Zhang, Christy Saju
Publikováno v:
BMC Medical Research Methodology, Vol 23, Iss 1, Pp 1-9 (2023)
Abstract Background Trial design plays a key role in clinical trials. Traditional group sequential design has been used in cardiovascular clinical trials over decades as the trials can potentially be stopped early, therefore, it can reduce pre-planne
Externí odkaz:
https://doaj.org/article/5a34fef72a0b4e9aacbe1b965f72c461
Autor:
Sabrina Das, Shawn Walker, Amy Meadowcroft, Kate Stringer, Jacana Bresson, Siân Davies, Jasmine Kang, Alice Hodder, Emma Spillane
Publikováno v:
NIHR Open Research, Vol 3 (2023)
Background OptiBreech collaborative care is a multi-disciplinary care pathway for breech presentation at term. The OptiBreech Multiple Trial Cohort is designed to host multiple trials related to care for breech presentation. This design enables prosp
Externí odkaz:
https://doaj.org/article/080ed4cab54c44f195dade2b44ddf084
Publikováno v:
Zhongguo cuzhong zazhi, Vol 17, Iss 11, Pp 1283-1287 (2022)
近年来，成组序贯设计因其可在期中分析时提前得出结论结束试验，具有更强的灵活性，已被广泛应用于临床试验中。本文将从背景、设计思路、与传统临床试验的比较、使用场景、案例解
Externí odkaz:
https://doaj.org/article/8bea73a819a54bf4bfc6cfd628092c01
Autor:
Long-Shen Xie, Hui Lu
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
A delayed treatment effect is a commonly observed phenomenon in tumor immunotherapy clinical trials. It can cause a loss of statistical power and complicate the interpretation of the analytical findings. This phenomenon also poses challenges for inte
Externí odkaz:
https://doaj.org/article/f6efd76a02bf46508ed7ee280705deae
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