ING2 Controls Mitochondrial Respiration via Modulating MRPL12 Ubiquitination in Renal Tubular Epithelial Cells

Autor: Ying Yang, Chensheng Li, Xia Gu, Junhui Zhen, Suwei Zhu, Tingting Lv, Qiang Wan, Yi Liu

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Mitochondrial injury of tubular epithelial cells (TECs) is the key pathogenic event underlying various kidney diseases and a potential intervening target as well. Our previous study demonstrated that ING2 is ubiquitously expressed at tubulointerstiti

Externí odkaz: https://doaj.org/article/16593aaf5d5a4037820ec8448f0d486a

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Antithetic htert regulation by androgens in prostate cancer cells: Htert inhibition is mediated by the ing1 and ing2 tumor suppressors

Autor: Bartsch, Sophie, Mirzakhani, Kimia, Neubert, Laura, Stenzel, Alexander, Ehsani, Marzieh, Esmaeili, Mohsen, Pungsrinont, Thanakorn, Kacal, Merve, Rasa, Seyed Mohammad Mahdi, Kallenbach, Julia, Damodaran, Divya, Ribaudo, Federico, Grimm, Marc-Oliver, Neri, Francesco, Baniahmad, Aria

Publikováno v: Cancers, Vol 13, Iss 4025, p 4025 (2021)
Cancers
Volume 13
Issue 16

Simple Summary The expression of the catalytic subunit of the human telomerase reverse transcriptase subunit (hTERT) is hormonally controlled. Androgen treatment suppresses the hTERT expression at a transcriptional level in prostate cancer cells. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7265b357da1a6024e759ffda49d09337
http://hdl.handle.net/2318/1834363

Exploiting ING2 Epigenetic Modulation as a Therapeutic Opportunity for Non-Small Cell Lung Cancer

Autor: Blondel, Alice, Benberghout, Amine, Pedeux, Remy, Ricordel, Charles

Publikováno v: Cancers
Cancers, MDPI, 2019, 11 (10), pp.E1601. ⟨10.3390/cancers11101601⟩
Cancers, Vol 11, Iss 10, p 1601 (2019)
Cancers, 2019, 11 (10), pp.E1601. ⟨10.3390/cancers11101601⟩

Non-small cell lung cancer (NSCLC) has been the leading cause of cancer-related death worldwide, over the last few decades. Survival remains extremely poor in the metastatic setting and, consequently, innovative therapeutic strategies are urgently ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::02268bbe993858b1b950266698808091
https://hal-univ-rennes1.archives-ouvertes.fr/hal-02365418

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