Zobrazeno 1 - 10
of 5 966
pro vyhledávání: '"INDUCIBLE FACTOR-1"'
Publikováno v:
International Journal of Nanomedicine, Vol Volume 19, Pp 10247-10262 (2024)
XingYun Liu,1,* JingDuo Zhao,2,* FuRong Liu,1 ZhiZhong Xie,2 XiaoYong Lei,2 Zhe Wang,3 Zerui Yang,4 YuSheng Zhou,1,3 GuoTao Tang2 1The Affiliated Nanhua Hospital, Department of Pharmacy, Hengyang Medical School, University of South China, Hen
Externí odkaz:
https://doaj.org/article/0af1b03e93bd48f384cd645cf565607e
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Cannabidiol (CBD) is a non-psychotomimetic phytocannabinoid derived from Cannabis sativa. It has therapeutic effects in different paradigms of brain injury, acting as a neuroprotectant. As oxidative stress is a primary risk factor for brain
Externí odkaz:
https://doaj.org/article/5ff0d1c4f6c84debb3fde1fae2afed69
Publikováno v:
Pharmacological Research, Vol 210, Iss , Pp 107537- (2024)
Externí odkaz:
https://doaj.org/article/70cd9ac076e64113852e003d6a37dc78
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The hypoxic microenvironment, characterized by significantly reduced oxygen levels within tissues, has emerged as a critical factor in the pathogenesis and progression of various autoimmune diseases (AIDs). Central to this process is the hypoxia-indu
Externí odkaz:
https://doaj.org/article/5404046180e840c38fb4a121873c38f1
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Hypoxia-inducible factor-1 (HIF-1) regulates cell growth, protein translation, metabolic pathways and therefore, has been advocated as a promising biological target for the therapeutic interventions against cancer. In general, hyperactivation of HIF-
Externí odkaz:
https://doaj.org/article/4e84d60b62394b378bc3b6e928507afc
Autor:
Nurhan Kuloğlu, Derya Karabulut, Emin Kaymak, Ali Tuğrul Akin, Tayfun Ceylan, Ayşegül Yıldırım, Birkan Yakan
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 27, Iss 6, Pp 733-739 (2024)
Objective(s): Methotrexate (MTX) is a drug with anti-inflammatory and immunosuppressive effects and is also a folic acid antagonist. Our aim in this study is to determine the molecular mechanisms of cardiotoxicity caused by MTX, a chemotherapeutic dr
Externí odkaz:
https://doaj.org/article/0367578f2ce14bd59de0462056a7d76d
Autor:
İlayda Altınönder, Mustafa Kaya, Sibel P. Yentür, Arman Çakar, Hacer Durmuş, Gülçin Yegen, Berker Özkan, Yeşim Parman, Amr H. Sawalha, Guher Saruhan-Direskeneli
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-10 (2024)
Abstract Myasthenia gravis (MG) is an immune-mediated disease frequently associated with thymic changes. Increased T helper 17 (Th17) cell activity and dysfunctional regulatory T (Treg) cells have been demonstrated in subgroups of MG. On the other ha
Externí odkaz:
https://doaj.org/article/22e3a343211b4a35a2bed8399f28723e
Publikováno v:
Guoji laonian yixue zazhi, Vol 45, Iss 02, Pp 229-233 (2024)
Diabetes mellitus(DM) stands as a multifaceted metabolic disorder marked by heightened blood glucose levels and an elusive pathogenesis.Hypoxia-inducible factor-1(HIF-1) emerges as a pivotal transcription factor triggered within hypoxic environments.
Externí odkaz:
https://doaj.org/article/1c0d675dfd2e404494fc9bb961bb3a98
Publikováno v:
Genes and Diseases, Vol 11, Iss 1, Pp 234-251 (2024)
The hypoxic microenvironment is an essential characteristic of most malignant tumors. Notably, hypoxia-inducible factor-1 alpha (HIF-1α) is a key regulatory factor of cellular adaptation to hypoxia, and many critical pathways are correlated with the
Externí odkaz:
https://doaj.org/article/300424bef78f417d810da6b82f0ac9b6
Publikováno v:
Medicina, Vol 60, Iss 7, p 1148 (2024)
Background and Objectives: In this study, we aimed to investigate the effects of bosentan, an endothelin receptor antagonist, on endothelin-1 (ET-1), hypoxia-inducible factor-1 (HIF-1), nuclear factor-kappa B (NF-κB), and tumor necrosis factor (TNF)
Externí odkaz:
https://doaj.org/article/e0982bdb5b234dfaa93b1f75ebdb3bbe