Pharmacokinetics of Tenofovir Alafenamide With Boosted Protease Inhibitors in Pregnant and Postpartum Women Living With HIV: Results From IMPAACT P1026s

Autor: Brooks, Kristina M, Pinilla, Mauricio, Stek, Alice M, Shapiro, David E, Barr, Emily, Febo, Irma L, Paul, Mary E, Deville, Jaime G, George, Kathleen, Knowles, Kevin, Rungruengthanakit, Kittipong, Browning, Renee, Chakhtoura, Nahida, Capparelli, Edmund V, Mirochnick, Mark, Best, Brookie M, IMPAACT P1026s Protocol Team

Publikováno v: Journal of acquired immune deficiency syndromes (1999), vol 90, iss 3

BackgroundTenofovir alafenamide (TAF) is a key component of HIV treatment, but pharmacokinetic data supporting the use of TAF during pregnancy are limited. In this study, we report pharmacokinetic, safety, and birth outcomes for TAF 25 mg with a boos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::f55dc37f42cac4e3de8f262dc95f3ad0
https://escholarship.org/uc/item/61z7p39s

Pharmacokinetics of Darunavir and Cobicistat in Pregnant and Postpartum Women with HIV

Autor: Impaact P s Protocol Team, Mary E. Paul, Sandra K. Burchett, Jeremiah D. Momper, Nahida Chakhtoura, Edmund V. Capparelli, Derek Z Yang, Irma Febo, Kittipong Rungruengthanakit, Kathleen George, Kayla Denson, Alice Stek, Jiajia Wang, Gwendolyn B. Scott, Elizabeth Smith, David Shapiro, Mark Mirochnick, Brookie M. Best

Publikováno v: AIDS
AIDS (London, England), vol 35, iss 8

OBJECTIVE To evaluate darunavir and cobicistat pharmacokinetics during pregnancy compared with postpartum and in infant washout samples after delivery. DESIGN Nonrandomized, open-label, parallel-group, multicenter phase-IV prospective study of daruna

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a0375d8ab0ca15fbd7ad1843bb89d9a
https://europepmc.org/articles/PMC8173003/

Darunavir Pharmacokinetics With an Increased Dose During Pregnancy

Autor: Impaact P s Protocol Team, Brookie M. Best, Nahida Chakhtoura, Regis Kreitchmann, David Shapiro, Elizabeth Smith, Edmund V. Capparelli, Mark Mirochnick, Alice Stek, Ahizechukwu C. Eke, Jiajia Wang

Publikováno v: Journal of acquired immune deficiency syndromes (1999), vol 83, iss 4
J Acquir Immune Defic Syndr

BackgroundThis study aims to evaluate the pharmacokinetics of an increased dose of darunavir (800 mg twice daily) with 100 mg ritonavir during pregnancy and postpartum.MethodsDarunavir (DRV) and ritonavir (RTV; r) intensive pharmacokinetic evaluation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741bf995afa13246ca636da94fd3fd70
https://escholarship.org/uc/item/6191s2wx

Pharmacokinetics of Rilpivirine in HIV-Infected Pregnant Women

Autor: Edmund V. Capparelli, David Shapiro, Kittipong Rungruengthanakit, Alice Stek, Sandra K. Burchett, Tim R. Cressey, Nahida Chakhtoura, Regis Kreitchmann, Impaact P s Protocol Team, Elizabeth Smith, Anna H Tran, Brookie M. Best, Mark Mirochnick, Jiajia Wang, Kathleen George

Publikováno v: Journal of acquired immune deficiency syndromes (1999), vol 72, iss 3
Tran, AH; Best, BM; Stek, A; Wang, J; Capparelli, EV; Burchett, SK; et al.(2016). Pharmacokinetics of Rilpivirine in HIV-Infected Pregnant Women. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 72(3), 289-296. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/8b3353br
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, vol 72, iss 3

BackgroundRilpivirine pharmacokinetics is defined by its absorption, distribution, metabolism, and excretion. Pregnancy can affect these factors by changes in cardiac output, protein binding, volume of distribution, and cytochrome P450 (CYP) 3A4 acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad6b94d163165bafb5f2108ebb383eb
https://escholarship.org/uc/item/8jd889qr