A case of multisystem inflammatory syndrome in children (MIS-C) mimicking Kawasaki disease

Autor: M. Rathnayake, L. Dassanayake, A. Fernando, A. Sadikeen

Publikováno v: Sri Lanka Journal of Medicine, Vol 30, Iss 2, Pp 144-148 (2021)

Introduction: Severe acute respiratory syndrome coronavirus-2 infection has emerged as a multisystem disorder during the pandemic of Coronavirus disease of 2019 (Covid-19). Multisystem inflammatory syndrome of children (MIS-C) is a rare grave complic

Externí odkaz: https://doaj.org/article/e185b374a92142f1be69d5e45c27e6fb

Multifaceted characterization of the signatures and efficacy of mesenchymal stem/stromal cells in acquired aplastic anemia

Autor: Jiali Huo, Leisheng Zhang, Xiang Ren, Chengwen Li, Xingxin Li, Peiyuan Dong, Xuan Zheng, Jinbo Huang, Yingqi Shao, Meili Ge, Jing Zhang, Min Wang, Neng Nie, Peng Jin, Yizhou Zheng

Publikováno v: Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-18 (2020)

Abstract Background Longitudinal studies have verified the pivotal role of mesenchymal stem/stromal cells (MSCs) in the bone marrow microenvironment for hematopoiesis and coordinate contribution to leukemia pathogenesis. However, the precise characte

Externí odkaz: https://doaj.org/article/772d71ebad964f3d87920b57d0d53c30

Druggable monogenic immune defects hidden in diverse medical specialties: Focus on overlap syndromes

Autor: Valentina Boz, Chiara Zanchi, Laura Levantino, Guglielmo Riccio, Alberto Tommasini

Publikováno v: World Journal of Clinical Pediatrics. 11:136-150

In the last two decades two new paradigms changed our way of perceiving primary immunodeficiencies: An increasing number of immune defects are more associated with inflammatory or autoimmune features rather than with infections. Some primary immune d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768c4cf08bdd9aecde5587486d49d7c5
https://doi.org/10.5409/wjcp.v11.i2.136

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TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C

Autor: MIS-C Clinicians, Hoste, Levi, Roels, Lisa, Naesens, Leslie, Bosteels, Victor, Vanhee, Stijn, Dupont, Sam, Bosteels, Cedric, Browaeys, Robin, Vandamme, Niels, Verstaen, Kevin, Roels, Jana, Van Damme, Karel F A, Maes, Bastiaan, De Leeuw, Elisabeth, Declercq, Jozefien, Aegerter, Helena, Seys, Leen, Smole, Ursula, De Prijck, Sofie, Vanheerswynghels, Manon, Claes, Karlien, Debacker, Veronique, Van Isterdael, Gert, Backers, Lynn, Claes, Kathleen B M, Bastard, Paul, Jouanguy, Emmanuelle, Zhang, Shen-Ying, Mets, Gilles, Dehoorne, Joke, Vandekerckhove, Kristof, Schelstraete, Petra, Willems, Jef, Stordeur, Patrick, Janssens, Sophie, Beyaert, Rudi, Saeys, Yvan, Casanova, Jean-Laurent, Lambrecht, Bart N, Haerynck, Filomeen, Tavernier, Simon J, Daelemans, Siel

Publikováno v: The Journal of Experimental Medicine
Journal of Experimental Medicine, 219(2):e20211381. Rockefeller University Press
JOURNAL OF EXPERIMENTAL MEDICINE

MIS-C is a novel immunodysregulation syndrome in children with a history of SARS-CoV-2 infection. This study employs a multi-omics approach to explore its immunopathogenesis. The authors show that IFNγ-mediated interactions between T cells, monocyte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0387779e65569f94f163c8e653bf49
https://doi.org/10.1084/jem.20211381