Zobrazeno 1 - 10
of 444
pro vyhledávání: '"IMGT"'
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-8 (2023)
Abstract Background The advent and continual improvement of high-throughput sequencing technologies has made immunoglobulin repertoire sequencing accessible and informative regardless of study species. However, to fully map dynamic changes in polyclo
Externí odkaz:
https://doaj.org/article/875da9652017451c9b98474de413dbd9
Autor:
Marie-Paule Lefranc, Gérard Lefranc
Publikováno v:
BioMedInformatics, Vol 3, Iss 3, Pp 649-690 (2023)
Human immunoglobulin allotypes are allelic antigenic determinants (or “markers”) determined serologically, classically by hemagglutination inhibition, on the human immunoglobulin (IG) or antibody heavy and light chains. The allotypes have been id
Externí odkaz:
https://doaj.org/article/736eb39ec2514e0a86f603887629f817
Autor:
Taciana Manso, Anjana Kushwaha, Nika Abdollahi, Patrice Duroux, Véronique Giudicelli, Sofia Kossida
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundCancer cells activate different immune checkpoint (IC) pathways in order to evade immunosurveillance. Immunotherapies involving ICs either block or stimulate these pathways and enhance the efficiency of the immune system to recognize and at
Externí odkaz:
https://doaj.org/article/f19caf02f4da4d539524af4bd7a834fa
Publikováno v:
Vaccines, Vol 11, Iss 12, p 1756 (2023)
Background: Myasthenia Gravis (MG) is a rare autoimmune disease presenting with auto-antibodies that affect the neuromuscular junction. In addition to symptomatic treatment options, novel therapeutics include monoclonal antibodies (mAbs). IMGT®, the
Externí odkaz:
https://doaj.org/article/f75b12c3d29f41c88e6bdb7a8e844383
Autor:
Giovanna Linguiti, Vincenzo Tragni, Ciro Leonardo Pierri, Serafina Massari, Marie-Paule Lefranc, Rachele Antonacci, Salvatrice Ciccarese
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The Camelidae species occupy an important immunological niche within the humoral as well as cell mediated immune response. Although recent studies have highlighted that the somatic hypermutation (SHM) shapes the T cell receptor gamma (TRG) and delta
Externí odkaz:
https://doaj.org/article/81ac443627554097a65cccceeeee70f8
Autor:
Jonathan Crider, Sylvie M. A. Quiniou, Kristianna L. Felch, Kurt Showmaker, Eva Bengtén, Melanie Wilson
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The complete germline repertoires of the channel catfish, Ictalurus punctatus, T cell receptor (TR) loci, TRAD, TRB, and TRG were obtained by analyzing genomic data from PacBio sequencing. The catfish TRB locus spans 214 kb, and contains 112 TRBV gen
Externí odkaz:
https://doaj.org/article/edad69a3968943df80276524363cd0e6
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
T-cell antigen receptors (TRs) in vertebrates can be divided into αβ or γδ, encoded by TRA/D, TRG, or TRB loci. TRs play a central role in mammal cellular immunity, which occurs by rearrangement of V, D, J, and C genes in the loci. The bat is the
Externí odkaz:
https://doaj.org/article/0534ddff420c4ec8942a71e0dbec76bb
Autor:
Marie-Paule Lefranc, Gérard Lefranc
Publikováno v:
Antibodies, Vol 11, Iss 4, p 65 (2022)
The constant region of the immunoglobulin (IG) or antibody heavy gamma chain is frequently engineered to modify the effector properties of the therapeutic monoclonal antibodies. These variants are classified in regards to their effects on effector fu
Externí odkaz:
https://doaj.org/article/bc36335292c54312b78b93048daf5a92
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Autor:
Viviane Nguefack Ngoune, Morgane Bertignac, Maria Georga, Ariadni Papadaki, Alexandre Albani, Géraldine Folch, Joumana Jabado-Michaloud, Véronique Giudicelli, Patrice Duroux, Marie-Paule Lefranc, Sofia Kossida
Publikováno v:
Vaccines, Vol 10, Iss 3, p 394 (2022)
The adaptive immune system, along with the innate immune system, are the two main biological processes that protect an organism from pathogens. The adaptive immune system is characterized by the specificity and extreme diversity of its antigen recept
Externí odkaz:
https://doaj.org/article/d14a95eb3c184332beed803ad1f50abc