Výsledky vyhledávání - "IMDM, Iscove's modified Dulbecco's medium"

Discovery of novel selective PI3Kγ inhibitors through combining machine learning-based virtual screening with multiple protein structures and bio-evaluation

Autor: Yanfei Cai, Jingyu Zhu, Yun Chen, Jian Jin, Xinling Zhao, Kan Li, Lei Xu, Huazhong Li, Gang Huang

Publikováno v: Journal of Advanced Research
Journal of Advanced Research, Vol 36, Iss, Pp 1-13 (2022)

Graphical abstract
Highlights • Virtual screening based on machine learning with multiple proteins was developed. • Discovery of a novel PI3Kγ inhibitor integrating virtual screening and bio-assays. • JN-KI3 selective inhibit PI3Kγ enzym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cdbf7fb8f578b72a0c3242e69513c71
https://doi.org/10.1016/j.jare.2021.04.007

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Monitoring Plasmodium vivax resistance to antimalarials: Persisting challenges and future directions

Autor: Simone Ladeia-Andrade, Rodrigo M. Corder, Marcelo U. Ferreira, Gabriel W. Rangel, Igor Cavallini Johansen, Taís Nóbrega de Sousa, José Pedro Gil

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 15, Iss, Pp 9-24 (2021)
International Journal for Parasitology: Drugs and Drug Resistance
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Emerging antimalarial drug resistance may undermine current efforts to control and eliminate Plasmodium vivax, the most geographically widespread yet neglected human malaria parasite. Endemic countries are expected to assess regularly the therapeutic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e5ae265fa9864da475e8994bd43548
http://www.sciencedirect.com/science/article/pii/S221132072030049X

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Induction of cell death and modulation of Annexin A1 by phytoestrogens in human leukemic cell lines

Autor: Affidah Sabran, Norazrina Azmi, Endang Kumolosasi, Ibrahim Jantan, Jamia Azdina Jamal, Malina Jasamai

Publikováno v: Saudi Pharmaceutical Journal, Vol 29, Iss 1, Pp 73-84 (2021)
Saudi Pharmaceutical Journal : SPJ

Graphical abstract
Background Phytoestrogens are polyphenolic plant compounds which are structurally similar to the endogenous mammalian estrogen, 17β-estradiol. Annexin A1 (ANXA1) is an endogenous protein which inhibits cyclo-oxygenase 2 (COX-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7af75acdc48e81fbb702d81d342d18
https://doi.org/10.1016/j.jsps.2020.12.011

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Preparation of polymer microspheres capable for pioglitazone release to modify macrophages function

Autor: Yasuhiko Tabata, Jun-ichiro Jo, Naoki Momotori

Publikováno v: Regenerative Therapy
Regenerative Therapy, Vol 11, Iss, Pp 131-138 (2019)

Introduction Macrophages play an important role in regulating inflammation and tissue regeneration. It is known that anti-inflammatory macrophages play an important role for tissue regeneration. The objective of this study is to modify macrophages ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b5587608bba67eb13c5b19ce632b607
https://doi.org/10.1016/j.reth.2019.06.008

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Cdc42 regulates reactive oxygen species production in the pathogenic yeast Candida albicans

Autor: Stéphanie Bogliolo, Asia S. Wildeman, Martine Bassilana, Valeria C. Culotta, Angelique N. Besold, Griffin P. Kowalewski

Publikováno v: The Journal of Biological Chemistry
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 297 (2), pp.100917. ⟨10.1016/j.jbc.2021.100917⟩

Across eukaryotes, Rho GTPases such as Rac and Cdc42 play important roles in establishing cell polarity, which is a key feature of cell growth. In mammals and filamentous fungi, Rac targets large protein complexes containing NADPH oxidases (NOX) that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22fd905105eed697b49b089b3e5754fb
https://doi.org/10.1016/j.jbc.2021.100917

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CTC phenotyping for a preoperative assessment of tumor metastasis and overall survival of pancreatic ductal adenocarcinoma patients

Autor: Kuang Hong Neoh, Guangdong Wu, Anqi Chen, Ray P. S. Han, Kok Suen Cheng, Shuiyu Chen, Yukun Sun, Zhewen Tang, Menghua Dai, Poh Foong Lee

Publikováno v: EBioMedicine

Background The evaluation for surgical resectability of pancreatic ductal adenocarcinoma (PDAC) patients is not only imaging-based but highly subjective. An objective method is urgently needed. We report on the clinical value of a phenotypic circulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d5c11fff5e53188b7b192a582557ce2
https://pubmed.ncbi.nlm.nih.gov/31375425

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Concentration- and time-dependent genotoxicity profiles of isoprene monoepoxides and diepoxide, and the cross-linking potential of isoprene diepoxide in cells

Autor: Jing An, Xinyu Zhang, Avishay Pelah, Yingxin Yu, Yan Li

Publikováno v: Toxicology Reports
Toxicology Reports, Vol 1, Iss C, Pp 36-45 (2014)

Highlights • Genotoxicity of monoepoxides and diepoxide of isoprene was assessed by comet assay. • Concentration- and time-dependent profiles in human hepatocyte cells were obtained. • Isoprene-3,4-oxide was the most potent in inducing DNA brea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d92e1db760dc8feaf5244d33cac99a
http://europepmc.org/articles/PMC5598284

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Frequency of acute myeloid leukaemia-associated mouse chromosome 2 deletions in X-ray exposed immature haematopoietic progenitors and stem cells

Autor: Natalie Brown, Simon Bouffler, Rosemary Finnon, Christophe Badie, C.-H. Olme

Publikováno v: Mutation Research

Exposure to ionising radiation can lead to an increased risk of cancer, particularly leukaemia. In radiation-induced acute myeloid leukaemia (rAML), a partial hemizygous deletion of mouse chromosome 2 is a common feature in several susceptible strain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ff371543b2f9b58c8abec333735cb1

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Function of the CysD domain of the gel-forming MUC2 mucin

Autor: Ute Krengel, Elisabeth Thomsson, Daniel Ambort, Gunnar C. Hansson, Jenny Mackenzie, Malin E. V. Johansson, Sjoerd van der Post

Publikováno v: Biochemical Journal; Vol 436
Biochemical Journal

The colonic human MUC2 mucin forms a polymeric gel by covalent disulfide bonds in its N- and C-termini. The middle part of MUC2 is largely composed of two highly O-glycosylated mucin domains that are interrupted by a CysD domain of unknown function.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8bf23ceff9561b204aa991b20e5ec7

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Human mesenchymal stem cells - current trends and future prospective

Autor: Imran Ullah, Gyu-Jin Rho, Raghavendra Baregundi Subbarao

Publikováno v: Bioscience Reports
Bioscience Reports, Vol 35, Iss 2, p e00191 (2015)

Stem cells are cells specialized cell, capable of renewing themselves through cell division and can differentiate into multi-lineage cells. These cells are categorized as embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs) and adult s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::562ee13e2bd22cb3930610489d275687
http://europepmc.org/articles/PMC4413017

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