Zobrazeno 1 - 10
of 48
pro vyhledávání: '"ILYAS YILDIRIM"'
Autor:
Amirhossein Taghavi, Ilyas Yildirim
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Expansions of RNA AUUCU, CCUG, CAG, and CUG repeats cause spinocerebellar ataxia type 10, myotonic dystrophy type 2, Huntington’s disease, and myotonic dystrophy type 1, respectively. By performing extensive molecular dynamic simulations, we invest
Externí odkaz:
https://doaj.org/article/72ad8f6b0b874765bf289ea302a13d9b
Publikováno v:
J Chem Theory Comput
RNA modulation via small molecules is a novel approach in pharmacotherapies, where the determination of the structural properties of RNA motifs is considered a promising way to develop drugs capable of targeting RNA structures to control diseases. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e049ceb7dd69ff5039b6cdb610a8cbb
https://doi.org/10.1021/acs.jctc.2c00178
https://doi.org/10.1021/acs.jctc.2c00178
Autor:
Amirhossein Taghavi, Jared T Baisden, Jessica L Childs-Disney, Ilyas Yildirim, Matthew D Disney
Publikováno v:
Nucleic Acids Research.
G4C2 and G2C4 repeat expansions in chromosome 9 open reading frame 72 (C9orf72) are the most common cause of genetically defined amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), or c9ALS/FTD. The gene is bidirectionally transcri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcb1d16c7421936d5469a4ffb96b2cd4
https://doi.org/10.1093/nar/gkad403
https://doi.org/10.1093/nar/gkad403
Publikováno v:
Biophysical journal.
Expansion of RNA CUG repeats causes myotonic dystrophy type 1 (DM1). Once transcribed, the expanded CUG repeats strongly attract muscleblind-like 1 (MBNL1) proteins and disturb their functions in cells. Because of its unique structural form, expanded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c57ff8a891c62ca7cee571dc832d99e
https://pubmed.ncbi.nlm.nih.gov/36348626
https://pubmed.ncbi.nlm.nih.gov/36348626
Autor:
Kye Won Wang, Simon Vezina-Dawod, Matthew D. Disney, Raphael I. Benhamou, Ilyas Yildirim, Shruti Choudhary, Samantha M. Meyer
Publikováno v:
Chembiochem
RNA molecules both contribute to and are causative of many human diseases. One method to perturb RNA function is to target its structure with small molecules. However, discovering bioactive ligands for RNA targets is challenging. Here, we show that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8c065c67c4063448c0ca2a253e94a9a
https://doi.org/10.1002/cbic.202000445
https://doi.org/10.1002/cbic.202000445
Autor:
Alexander Adibekian, Ilyas Yildirim, Daniel Abegg, Jonas Boström, Hafeez S. Haniff, Malin Lemurell, Matthew D. Disney, Elizabeth Lekah, Michael D. Cameron, Gogce Crynen, Kye Won Wang, Laurent Knerr, Xiaohui Liu
Publikováno v:
Nature chemistry
Vascular endothelial growth factor A (VEGFA) stimulates angiogenesis in human endothelial cells, and increasing its expression is a potential treatment for heart failure. Here, we report the design of a small molecule (TGP-377) that specifically and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58702304fbf35d8ca290ba80c49bf9e4
https://doi.org/10.1038/s41557-020-0514-4
https://doi.org/10.1038/s41557-020-0514-4
Autor:
Jeffrey D. Rothstein, Jonathan L. Chen, Montina Van Meter, Tania F. Gendron, Alyssa N. Coyne, Yong Jie Zhang, Eric T. Wang, Yue Li, Ilyas Yildirim, Rita Fuerst, Jessica A. Bush, Leonard Petrucelli, Samantha M. Meyer, Hailey Olafson, Jessica L. Childs-Disney, Kye Won Wang, Yuquan Tong, Kendra K. McKee, Raphael I. Benhamou, Tanya Khan, Andrei Ursu, Matthew D. Disney, Sarah Wagner-Griffin, Haruo Aikawa
Publikováno v:
Sci Transl Med
The most common cause of amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD) is an expanded G(4)C(2) RNA repeat [r(G(4)C(2))(exp)] in chromosome 9 open reading frame 72 (C9orf72), which elicits pathology through several mechanisms.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c7323437f11575a5a155e154c7f4b4
https://europepmc.org/articles/PMC9533739/
https://europepmc.org/articles/PMC9533739/
Autor:
Jessica A. Bush, Andrei Ursu, Amirhossein Taghavi, Matthew D. Disney, Shruti Choudhary, Leonard Petrucelli, Yong Jie Zhang, Jared T. Baisden, Ilyas Yildirim, Tania F. Gendron
Publikováno v:
ACS Chem Neurosci
The hexanucleotide repeat expansion GGGGCC [r(G(4)C(2))(exp)] within intron 1 of C9orf72 causes genetically defined amyotrophic lateral sclerosis and frontotemporal dementia, collectively named c9ALS/FTD. , the repeat expansion causes neurodegenerati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9862d533df9726819e1b4bdf5dd074d
https://europepmc.org/articles/PMC9594102/
https://europepmc.org/articles/PMC9594102/
Publikováno v:
The Journal of Physical Chemistry B. 123:57-65
Mutations in the human tau gene result in alternative splicing of the tau protein, which causes frontotemporal dementia and Parkinsonism. One disease mechanism is linked to the stability of a hairpin within the microtubule-associated protein tau (MAP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05f088a5b5b00bd26628d24336f079ff
https://doi.org/10.1021/acs.jpcb.8b09139
https://doi.org/10.1021/acs.jpcb.8b09139
Autor:
Shruti Choudhary, Ilyas Yildirim, Matthew D. Disney, Kye Won Wang, Simon Vezina-Dawod, Alicia J. Angelbello
Publikováno v:
ACS Med Chem Lett
[Image: see text] RNA contributes to disease pathobiology and is an important therapeutic target. The downstream biology of disease-causing RNAs can be short-circuited with small molecules that recognize structured regions. The discovery and optimiza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d67eb2034d02c612aaf7aacab1d5352
https://pubmed.ncbi.nlm.nih.gov/34141068
https://pubmed.ncbi.nlm.nih.gov/34141068