Zobrazeno 1 - 10
of 328
pro vyhledávání: '"IL6R"'
Publikováno v:
Heliyon, Vol 10, Iss 18, Pp e37715- (2024)
AML is a malignant tumor derived from the hematopoietic system, which has a poor prognosis and its incidence is increasing recent years. LncRNAs bind to miRNAs as competitive endogenous RNAs to regulate the occurrence and progression of AML, with I
Externí odkaz:
https://doaj.org/article/2efc0a7167f44eca9ff05c15a3776a04
Autor:
Ding-Qiang Chen, Wen-Bin Xu, Zhi-Qiang Que, Ke-Yi Xiao, Nai-Kun Sun, Di-Xin Cai, Jin-Yi Feng, Gang Rui
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
ObjectiveInterleukin-6 (IL-6) is a multiple-effect cell factor implicated in the etiopathogenesis of several rheumatologic disorders. The blockade of the IL-6 pathway via IL6R inhibitors effectively treats these disorders. However, the clinical signi
Externí odkaz:
https://doaj.org/article/fdb63a770a234046ad2859a62927bcf4
Autor:
Варвара Ивановна Минина, Анастасия Александровна Яковлева, Анастасия Валерьевна Понасенко, Ольга Александровна Соболева, Анастасия Владимировна Торгунакова, Елена Александровна Киселева, Лидия Александровна Варич, Татьяна Андреевна Толочко, Анна Дмитриевна Веснина, Игорь Анатольевич Те, Яна Александровна Захарова
Publikováno v:
Medicina v Kuzbasse, Vol 22, Iss 4, Pp 79-86 (2023)
Obesity is a multifactorial disease, and the genetic component occupies an important place in its pathogenesis. One of the most studied and closely associated with monogenic obesity is the FTO (fat mass and obesity associated) gene. At the same time,
Externí odkaz:
https://doaj.org/article/b5878fc4e97e4eb1b3a4691c7ee3b191
Autor:
Luis Sainz, Pau Riera, Patricia Moya, Sara Bernal, Jordi Casademont, Cesar Díaz-Torné, Ana Milena Millán, Hye Sang Park, Adriana Lasa, Hector Corominas
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-10 (2023)
Abstract Background Sarilumab, an IL-6 receptor antagonist, is a first-line biologic disease-modifying anti-rheumatic drug for rheumatoid arthritis. The identification of genetic biomarkers as predictors of response to sarilumab could allow for a per
Externí odkaz:
https://doaj.org/article/0444fe7ddf56436ab6f8401650ec4da3
Autor:
Andrzej Dmytrzak, Klaudyna Lewandowska, Agnieszka Boroń, Beata Łoniewska, Natalie Grzesch, Andrzej Brodkiewicz, Jeremy S. C. Clark, Andrzej Ciechanowicz, Dorota Kostrzewa-Nowak
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5284 (2024)
A keloid is a benign fibroproliferative hypertrophy of scar tissue that extends outside the original wound and invades adjacent healthy skin. Keloid formation is thought to be a complex process including overactivity of the interleukin-6 signaling pa
Externí odkaz:
https://doaj.org/article/6abfbcd741c04f5abe62ac724c2ae2e5
Autor:
Fergus Hamilton, Ruth E Mitchell, Andrei Constantinescu, David Hughes, Aubrey Cunnington, Peter Ghazal, Nicholas J. Timpson
Publikováno v:
International Journal of Infectious Diseases, Vol 129, Iss , Pp 251-259 (2023)
Objectives: Severe malaria remains a deadly disease for many young children in low- and middle-income countries. Levels of interleukin (IL)-6 have been shown to identify cases of severe malaria and associate with severity, but it is unknown if this a
Externí odkaz:
https://doaj.org/article/47fdac61a56042b782fee2679b26b6cd
Autor:
Jalal Taneera, Anila Khalique, Abdul Khader Mohammed, Bashair M. Mussa, Nabil Sulaiman, Eman Abu-Gharbieh, Waseem El-Huneidi, Maha M. Saber-Ayad
Publikováno v:
Cells, Vol 13, Iss 8, p 685 (2024)
Interleukin-6 (IL6) is a pleiotropic cytokine implicated in metabolic disorders and inflammation, yet its precise influence on insulin secretion and glucose metabolism remains uncertain. This study examined IL6 expression in pancreatic islets from in
Externí odkaz:
https://doaj.org/article/2dc96a26ec49439c9c437eddb83a8441
Akademický článek
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Publikováno v:
Autoimmunity, Vol 55, Iss 4, Pp 264-274 (2022)
Background Osteosarcoma is a common primary bone tumour in children and adolescents. Circular RNAs (circRNAs) exert vital functions in human diseases, including osteosarcoma. Therefore, we explored the role of circ_0016347 in osteosarcoma. Methods Th
Externí odkaz:
https://doaj.org/article/cd568f496b754f1cbbeab2e7e56dde7f
Publikováno v:
Cancer Cell International, Vol 22, Iss 1, Pp 1-12 (2022)
Highlights EIF3B is a prognostic biomarker for HNSCC risk; EIF3B promotes HNSCC progression in vitro and in vivo; EIF3B promotes CEBPB translation and activates the MAPK pathway; IL6R and CCNG2 are targets of EIF3B-regulated CEBPB translation.
Externí odkaz:
https://doaj.org/article/d42317d0342049439d9f8ed7b8d0b3f1