Zobrazeno 1 - 10
of 964
pro vyhledávání: '"IKZF1"'
Autor:
Lili Pan, Yiqiao Chen, Kaizhi Weng, Biyun Guo, Shuquan Zhuang, Shuxian Huang, Zhulan Lian, Xiaofang Wang, Nainong Li, Yongzhi Zheng
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Background The predictive importance of IKZF1 del in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) has shown variability across different studies. Thus, the optimal treatment approach for children with IKZF1 del BCP-ALL r
Externí odkaz:
https://doaj.org/article/3f9d13721efb41f4964c9613a32a8e7a
Autor:
Caroline Barbieri Blunck, Caroline Pires Poubel, Bruno A. Lopes, Thayana C. Barbosa, Ana Luiza Tardem Maciel, Elaine Sobral da Costa, Ariadne da Rocha Figueiredo, Marcelo G.P. Land, Márcia Trindade Schramm, Maura Rosane Valério Ikoma-Coltutato, Renan Garcia Gomes, Mecneide Mendes Lins, Thais Ferraz Aguiar, Marcela Braga Mansur, Mariana Emerenciano
Publikováno v:
Translational Oncology, Vol 50, Iss , Pp 102127- (2024)
The presence of IKZF1 deletions has been associated with an increased relapse rate in B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). There is a particular subset of IKZF1del cases called IKZF1plus (defined by the co-occurrence of IKZF1del
Externí odkaz:
https://doaj.org/article/b369b5b82042416a9c4ee9b88e26c7e0
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
The IKZF1 gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The protein product, IKAROS, had been proved to regulate lymphopoiesis. Subsequent mouse model studies
Externí odkaz:
https://doaj.org/article/77e334e9d4d84494b6bdb7a585c0b9bf
Akademický článek
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Akademický článek
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Autor:
Timmy Strauss, Julia Körholz, Hye Sun Kuehn, Agustin A. Gil Silva, Franziska Taube, Karolin Trautmann-Grill, Anna Stittrich, Leonora Pietzsch, Ralf Wiedemuth, Volker Wahn, Horst von Bernuth, Sergio D. Rosenzweig, Maria Fasshauer, Renate Krüger, Catharina Schuetz
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
Heterozygous germline variants in human IKZF1 encoding for IKAROS define an inborn error of immunity with immunodeficiency, immune dysregulation and risk of malignancy with a broad phenotypic spectrum. Growing evidence of underlying pathophysiologica
Externí odkaz:
https://doaj.org/article/3e8835010a834401813ac42077f21c6e
Autor:
Joaquin Garcia-Solorio, Juan Carlos Núñez-Enriquez, Marco Jiménez-Olivares, Janet Flores-Lujano, Fernanda Flores-Espino, Carolina Molina-Garay, Alejandra Cervera, Diana Casique-Aguirre, José Gabriel Peñaloza-Gonzalez, Ma. Del Rocío Baños-Lara, Ángel García-Soto, César Alejandro Galván-Díaz, Alberto Olaya-Vargas, Hilario Flores Aguilar, Minerva Mata-Rocha, Miguel Ángel Garrido-Hernández, Juan Carlos Solís-Poblano, Nuria Citlalli Luna-Silva, Lena Sarahi Cano-Cuapio, Pierre Mitchel Aristil-Chery, Fernando Herrera-Quezada, Karol Carrillo-Sanchez, Anallely Muñoz-Rivas, Luis Leonardo Flores-Lagunes, Elvia Cristina Mendoza-Caamal, Beatriz Eugenia Villegas-Torres, Vincent González-Osnaya, Elva Jiménez-Hernández, José Refugio Torres-Nava, Jorge Alfonso Martín-Trejo, María de Lourdes Gutiérrez-Rivera, Rosa Martha Espinosa-Elizondo, Laura Elizabeth Merino-Pasaye, María Luisa Pérez-Saldívar, Silvia Jiménez-Morales, Everardo Curiel-Quesada, Haydeé Rosas-Vargas, Juan Manuel Mejía-Arangure, Carmen Alaez-Verson
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundRecurrent genetic alterations contributing to leukemogenesis have been identified in pediatric B-cell Acute Lymphoblastic Leukemia (B-ALL), and some are useful for refining classification, prognosis, and treatment selection. IKZF1plus is a
Externí odkaz:
https://doaj.org/article/957fbd226ef74958b32478db98abf26c
Publikováno v:
Jichu yixue yu linchuang, Vol 43, Iss 6, Pp 916-922 (2023)
Objective To explore potential function of IKAROS family zinc finger 1 (Ikzf1) in terminal erythroid differentiation. Methods Single-cell regulatory network inference and clustering (SCENIC) was used to predict transcription factors of terminal eryth
Externí odkaz:
https://doaj.org/article/7ac95e8f6305475492c51e62e626680c
Autor:
A. Roy, M. Shepherdson, K. Gormly, S. Byrne, S. Pedersen, T. Price, S. Vatandoust, C.S. Karapetis, G.P. Young, E.L. Symonds
Publikováno v:
ESMO Gastrointestinal Oncology, Vol 2, Iss , Pp 100013- (2023)
Background: Recurrence of colorectal cancer has been linked to the presence of methylated circulating tumour DNA (ctDNA) in patient plasma after surgery. The prognostic significance of ctDNA before treatment remains unclear. This study investigated t
Externí odkaz:
https://doaj.org/article/565f2aec7b35442d92651f8c805d1693
Autor:
Xiang Zhang, Aijie Huang, Lixia Liu, Jiayue Qin, Chengcheng Wang, Min Yang, Yinjun Lou, Lei Wang, Xiong Ni, Xiaoxia Hu, Gusheng Tang, Mengmeng Zhang, Shanbo Cao, Liping Mao, Jiejin Qian, Weilai Xu, Juying Wei, Gaixiang Xu, Haitao Meng, Wenyuan Mai, Chunmei Yang, Honghu Zhu, Hongyan Tong, Jianmin Yang, Wenjuan Yu, Jianmin Wang, Jie Jin
Publikováno v:
Experimental Hematology & Oncology, Vol 12, Iss 1, Pp 1-5 (2023)
Abstract Genetic heterogeneity poses a great challenge to the understanding and management of acute myeloid leukemia (AML). Knowledge of the IKZF1 mutation in AML specifically is extremely limited. In a previous work, we described the distribution pa
Externí odkaz:
https://doaj.org/article/acaa58acb0264dacb397be5dd0cd2bcf