Výsledky vyhledávání

Akademický článek

Phosphatase inhibition by sodium orthovanadate displays anti-inflammatory action by suppressing AKT-IKKβ signaling in RAW264.7 cells

Autor: Han Gyung Kim, Seong-Gu Jeong, Ji Hye Kim, Jae Youl Cho

Publikováno v: Toxicology Reports, Vol 9, Iss , Pp 1883-1893 (2022)

Sodium orthovanadate (Na3VO4) is an inhibitor of phosphatases that acts as a phosphate analog and is being developed as an anti-diabetes drug. Phosphatases play important roles in inflammatory signal pathways by modulating the removal of phosphate mo

Externí odkaz: https://doaj.org/article/3f5a06a6522f4c09be8d3b3b18b1089a

Zobrazit plný text záznamu

Akademický článek

Brevilin A Ameliorates Acute Lung Injury and Inflammation Through Inhibition of NF-κB Signaling via Targeting IKKα/β

Autor: Lu Liu, Xian Chen, Yifang Jiang, Yun Yuan, Luyao Yang, Qiongying Hu, Jianyuan Tang, Xianli Meng, Chunguang Xie, Xiaofei Shen

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Acute lung injury (ALI) is life-threatening disease characterized by uncontrolled inflammatory response. IKKα/β, the key kinases in the activation of NF-κB pathway, are implicated in inflammatory pulmonary injury, and represent attractive targets

Externí odkaz: https://doaj.org/article/ba01689cc35e4509804866a4463af52d

Zobrazit plný text záznamu

Akademický článek

Dehydrocostus Lactone Suppresses Dextran Sulfate Sodium-Induced Colitis by Targeting the IKKα/β-NF-κB and Keap1-Nrf2 Signalling Pathways

Autor: Yun Yuan, Qiongying Hu, Lu Liu, Fan Xie, Luyao Yang, Yuchen Li, Chuantao Zhang, Hongqing Chen, Jianyuan Tang, Xiaofei Shen

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Dehydrocostus lactone (DCL) is a major sesquiterpene lactone isolated from Aucklandia lappa Decne, a traditional Chinese herbal medicine that used to treat gastrointestinal diseases. This study aimed to examine the therapeutic effects of DCL on dextr

Externí odkaz: https://doaj.org/article/a2f642710df04204add93b49690a9dab

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Akademický článek

Sorbaria kirilowii Ethanol Extract Exerts Anti-Inflammatory Effects In Vitro and In Vivo by Targeting Src/Nuclear Factor (NF)-κB

Autor: Jiwon Jang, Jong Sub Lee, Young-Jin Jang, Eui Su Choung, Wan Yi Li, Sang Woo Lee, Eunji Kim, Jong-Hoon Kim, Jae Youl Cho

Publikováno v: Biomolecules, Vol 10, Iss 5, p 741 (2020)

Inflammation is a fundamental process for defending against foreign antigens that involves various transcriptional regulatory processes as well as molecular signaling pathways. Despite its protective roles in the human body, the activation of inflamm

Externí odkaz: https://doaj.org/article/7ed9e39a1fd7426ca403af1285f5c1a3

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Serum- and Glucocorticoid-Inducible Kinase 1 Sensitive NF-κB Signaling in Dendritic Cells

Autor: Evi Schmid, Nguyen Thi Xuan, Naima Zahir, Antonella Russo, Wenting Yang, Dietmar Kuhl, Caterina Faggio, Ekaterina Shumilina, Florian Lang

Publikováno v: Cellular Physiology and Biochemistry, Vol 34, Iss 3, Pp 943-954 (2014)

Background/Aims: Dendritic cells (DCs), antigen-presenting cells linking innate and adaptive immunity, are required for initiation of specific T cell-driven immune responses. Phosphoinositide-3-kinase (PI3K) suppresses proinflammatory cytokine produc

Externí odkaz: https://doaj.org/article/7e36daa979814668a0586d2e85ae96a2

Zobrazit plný text záznamu

Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model

Autor: Yaqin Sun, Ayaz Najafov, Qiming Sun, Zhe Wang, Tingjun Hou, Qingwei Zhao, Xufeng Cen, Tingxue Xie, Bing Shan, Mengmeng Zhang, Hongguang Xia, Cong Yi, Di Peng, Xiaoyan Xu, Yu Xue

Publikováno v: Protein & Cell

Chaperone-mediated autophagy (CMA) is a lysosome-dependent selective degradation pathway implicated in the pathogenesis of cancer and neurodegenerative diseases. However, the mechanisms that regulate CMA are not fully understood. Here, using unbiased

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25df0a2b4d82426006c586e641b2d64
https://pubmed.ncbi.nlm.nih.gov/34725788

Zobrazit plný text záznamu

Dihydrosphingosine driven enrichment of sphingolipids attenuates TGFβ induced collagen synthesis in cardiac fibroblasts

Autor: Bernard L. Flynn, Ruth R Magaye, Xin Xiong, Peter J Meikle, Danny Liew, Feby Savira, Kevin Huynh, David M. Kaye, Bing Hui Wang, Christopher M. Reid

Publikováno v: International Journal of Cardiology. Heart & Vasculature
International Journal of Cardiology: Heart & Vasculature, Vol 35, Iss, Pp 100837-(2021)

Graphical abstract
Highlights • Increasing sphingolipid metabolism in cardiac fibroblasts inhibited TGFβ mediated collagen synthesis. • Dihydrosphingosine inhibits collagen synthesis in cardiac fibroblasts through substrate-enzyme-receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7107d8c58bf953de354bb354b3a6ef20
https://pubmed.ncbi.nlm.nih.gov/34277924

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání