Zobrazeno 1 - 10
of 588
pro vyhledávání: '"IJzerman, A.P."'
Autor:
Bongers, B.J., Sijben, H.J., Hartog, P.B.R., Tarnovskiy, A., IJzerman, A.P., Heitman, L.H., Westen, G.J.P. van
Publikováno v:
Journal of Chemical Information and Modeling, 63(6):1745-1755
Solute carriers (SLCs) are relatively underexplored compared to other prominent protein families such as kinases and G protein-coupled receptors. However, proteins from the SLC family play an essential role in various diseases. One such SLC is the hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f737d4ed6a1e883f259e2d9036d42e49
https://doi.org/10.1021/acs.jcim.2c01645
https://doi.org/10.1021/acs.jcim.2c01645
Publikováno v:
Journal of Cheminformatics, 15(1):24
Rational drug design often starts from specific scaffolds to which side chains/substituents are added or modified due to the large drug-like chemical space available to search for novel drug-like molecules. With the rapid growth of deep learning in d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c48699d94b7f5098883f4e3883af82b
https://doi.org/10.1186/s13321-023-00694-z
https://doi.org/10.1186/s13321-023-00694-z
Autor:
Béquignon, O.J.M., Bongers, B.J., Jespers, W., IJzerman, A.P., Water, B. van de, Westen, G.J.P. van
Publikováno v:
Journal of cheminformatics, 15(1):3
With the ongoing rapid growth of publicly available ligand–protein bioactivity data, there is a trove of valuable data that can be used to train a plethora of machine-learning algorithms. However, not all data is equal in terms of size and quality
Akademický článek
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Publikováno v:
GPCRs as therapeutic targets, 631-676. John Wiley & Sons
STARTPAGE=631;ENDPAGE=676;TITLE=GPCRs as therapeutic targets
STARTPAGE=631;ENDPAGE=676;TITLE=GPCRs as therapeutic targets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b51e4d141c3ba2e1eba3cf6ca5bb0c
https://doi.org/10.1002/9781119564782.ch18
https://doi.org/10.1002/9781119564782.ch18
Publikováno v:
Drug Discovery Today, 27(6), 1661-1670. Elsevier BV
The integration of machine learning and structure-based methods has proven valuable in the past as a way to prioritize targets and compounds in early drug discovery. In oncological research, these methods can be highly beneficial in addressing the di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b553201e04f8257a32ec683dea9543e8
http://hdl.handle.net/1887/3420600
http://hdl.handle.net/1887/3420600
Autor:
Wang, X., Jespers, W., Waal, J.J. de, Wolff, K.A.N., Uden, L. van, IJzerman, A.P., Westen, G.J.P. van, Heitman, L.H.
Publikováno v:
The FASEB Journal, 36(6):e22358
G protein-coupled receptors (GPCRs) are known to be involved in tumor progression and metastasis. The adenosine A1 receptor (A1 AR) has been detected to be over-expressed in various cancer cell lines. However, the role of A1 AR in tumor development i
Akademický článek
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Autor:
Hollander, L.S. den, Béquignon, O.J.M., Wang, X., Wezel, K. van, Broekhuis, J.D., Gorostiola Gonzalez, M., Visser, K.E. de, IJzerman, A.P., Westen, G.J.P. van, Heitman, L.H.
Publikováno v:
Biochemical Pharmacology, 209:115450, 115540
Refers toImpact of cancer-associated mutations in CC chemokine receptor 2 on receptor function and antagonismBiochemical Pharmacology, Volume 208, February 2023, Pages 115399L.S. den Hollander, O.J.M. Béquignon, X. Wang, K. van Wezel, J. Broekhuis,
Autor:
Beerkens, B.L.H., Wang, X., Avgeropoulou, M., Adistia, L.N., Veldhoven, J.P.D. van, Jespers, W., Liu, R., Heitman, L.H., IJzerman, A.P., Es, D. van der
Publikováno v:
RSC Med Chem
RSC Medicinal Chemistry, 13(7), 850-856. Royal Society of Chemistry ({RSC})
RSC Medicinal Chemistry, 13(7), 850-856. Royal Society of Chemistry ({RSC})
Signalling through the adenosine receptors (ARs), in particular through the adenosine A(2B) receptor (A(2B)AR), has been shown to play a role in a variety of pathological conditions, ranging from immune disorders to cancer. Covalent ligands for the A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c50868929ca832d8b54aad1a9487ffe9
https://hdl.handle.net/1887/3479626
https://hdl.handle.net/1887/3479626