Výsledky vyhledávání - "IIya S. Dovydenko"

42- and 63-bp anti-MDR1-siRNAs bearing 2'-OMe modifications in nuclease-sensitive sites induce specific and potent gene silencing

Autor: Marina A. Zenkova, Valentin V. Vlassov, IIya S. Dovydenko, Elena L. Chernolovskaya, Olga V. Gvozdeva, Alya G. Venyaminova

Publikováno v: FEBS letters. 588(6)

DsRNAs longer than 30bp induce interferon response and global changes in gene expression profile in mammalians. 21bp siRNA and 25/27bp dsiRNA acting via RNA interference mechanism are used for specific gene silencing in this class of organisms. We de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7aede5f9110453f3912fa9c81869045
https://pubmed.ncbi.nlm.nih.gov/24561194

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Carrier-free cellular uptake and the gene-silencing activity of the lipophilic siRNAs is strongly affected by the length of the linker between siRNA and lipophilic group

Autor: Marina A. Zenkova, Aliya G. Venyaminova, Ivan V. Chernikov, Valentin V. Vlassov, IIya S. Dovydenko, Natalya S. Petrova, Mariya I. Meschaninova, Elena L. Chernolovskaya

Publikováno v: Nucleic Acids Research

The conjugation of siRNA to molecules, which can be internalized into the cell via natural transport mechanisms, can result in the enhancement of siRNA cellular uptake. Herein, the carrier-free cellular uptake of nuclease-resistant anti-MDR1 siRNA eq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c895b62f600a9b73571690be266cfbb3
https://pubmed.ncbi.nlm.nih.gov/22080508

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