Zobrazeno 1 - 10
of 24
pro vyhledávání: '"IHH, Indian hedgehog"'
Autor:
Xian Zeng, Dianwen Ju, Jiajun Fan, Yichen Wang, Jinghui Zhang, Jingyun Luan, Kai Yin, Mingming Nie
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 609-620 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 609-620 (2021)
The Hedgehog (HH) signaling pathway plays important roles in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment (TME). Aberrant HH signaling activation may accelerate the growth of gastrointestinal tumors and lead to tumo
Autor:
Sai Yao, Fangda Fu, Peijian Tong, Hongting Jin, Taotao Xu, Hongfeng Ruan, Chengliang Wu, Huan Yu, Di Chen, Huan Luo
Publikováno v:
Journal of Orthopaedic Translation, Vol 24, Iss, Pp 103-111 (2020)
Journal of Orthopaedic Translation
Journal of Orthopaedic Translation
Summary Purpose The purpose of our study was to introduce and validate a metal-free, reproducible and reliable mouse model of anterior cruciate ligament (ACL) reconstruction (ACLR) surgery as an effective tool for a better understanding of molecular
Autor:
Annemieke M. Boot, Henk van den Berg, Peter A A Struijs, Carline E. Tacke, Rick R. van Rijn, Abeltje M. Polstra, Christiaan F. Mooij, Astrid S Plomp, Suzanne W.J. Terheggen-Lagro
Publikováno v:
Bone reports, 14:101067. De Tijdstroom/Elsevier
Bone reports, 14:101067. Elsevier Inc.
Bone Reports, Vol 14, Iss, Pp 101067-(2021)
Bone Reports
Bone reports, 14:101067. Elsevier Inc.
Bone Reports, Vol 14, Iss, Pp 101067-(2021)
Bone Reports
Parathyroid hormone-like hormone (PTHLH) plays an important role in bone formation. Several skeletal dysplasias have been described that are associated with disruption of PTHLH functioning. Here we report on a new patient with a 898 Kb duplication on
Publikováno v:
Matrix Biology Plus
Matrix Biology Plus, Vol 12, Iss, Pp 100088-(2021)
Matrix Biology Plus, Vol 12, Iss, Pp 100088-(2021)
Highlights • Runx2 loss in hypertrophic chondrocytes (Runx2HC/HC) causes limb dwarfism in mice. • Decreased apoptosis leads to doubling of the zone of hypertrophic chondrocytes. • Runx2HC/HC hypertrophic chondrocytes barely expresses Mmps and a
Autor:
Tsutomo Kume, Fred B. Berry, Yawen Hu, Nikola Srnic, Asra Almubarak, Rotem Lavy, Devi Priyanka Maripuri
Publikováno v:
The Journal of Biological Chemistry
Endochondral ossification forms and grows the majority of the mammalian skeleton and is tightly controlled through gene regulatory networks. The forkhead box transcription factorsFoxc1andFoxc2have been demonstrated to regulate aspects of osteoblast f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b60b587dd04ba551feaceb593cb75a4
https://doi.org/10.1101/2021.01.27.428508
https://doi.org/10.1101/2021.01.27.428508
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 4, Pp 841-856 (2019)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims The Onecut 1 transcription factor (Oc1, a.k.a. HNF6) promotes differentiation of endocrine and duct cells of the pancreas; however, it has no known role in acinar cell differentiation. We sought to better understand the role of Oc1
Publikováno v:
Redox Biology, Vol 25, Iss, Pp-(2019)
Redox Biology
Redox Biology
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma accounting for 5–8% of malignant tumours in children and adolescents. Children with high risk disease have poor prognosis. Anti-RMS therapies include surgery, radiation and combination c
Publikováno v:
Biochemical Journal
Stem cells are undifferentiated cells that can self-renew and generate specialized (functional) cell types. The remarkable ability of stem cells to differentiate towards functional cells makes them suitable modalities in cellular therapy (which means
Autor:
Dan Feng, Lixin Xie, Huijuan Wang, Jie Deng, Pengjun Zhang, You-ning Liu, Zhi-rui Zhao, Yanhong Jia, Kun Xiao, Bao-zeng Wang, Xin Zhang
Publikováno v:
Clinical Science (London, England : 1979)
The goal of the present study was to identify novel protein biomarkers from the target genes of six serum miRNAs that we identified previously in patients with sepsis. The target genes were predicted by bioinformatics analysis; the levels of the resp
Autor:
Pim J. Koelink, Rogier Versteeg, Manon E. Wildenberg, Jan Koster, Anja Uhmann, Vanesa Muncan, Clinton Y. Snel, Gijs R. van den Brink, Nikè V. J. A. Büller, Olga N. Karpus, Joris J. T. H. Roelofs, Jarom Heijmans, Willemijn A. van Dop, B. Florien Westendorp, Heidi Hahn, Emiel Ver Loren van Themaat, Sander Meisner
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 1, Pp 67-82.e1 (2018)
Cellular and molecular gastroenterology and hepatology, 5(1), 67-82.e1. Elsevier Inc.
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 1, Pp 67-82.e1 (2018)
Cellular and molecular gastroenterology and hepatology, 5(1), 67-82.e1. Elsevier Inc.
Background & Aims Upon intestinal epithelial damage a complex wound healing response is initiated to restore epithelial integrity and defend against pathogenic invasion. Epithelium-derived Indian Hedgehog (Ihh) functions as a critical sensor in this