Zobrazeno 1 - 10
of 1 955
pro vyhledávání: '"IGHV"'
Autor:
Ingrid Glimelius, Geffen Kleinstern, Dennis P. Robinson, Larry Mansouri, Klaus Rostgaard, Henrik Hjalgrim, Carsten Utoft Niemann, Mattias Mattsson, Kari G. Rabe, Paul J. Hampel, Sameer A. Parikh, Richard Rosenquist, James R. Cerhan, Susan L. Slager, Karin E. Smedby
Publikováno v:
eJHaem, Vol 5, Iss 5, Pp 998-1004 (2024)
Abstract Background Chronic lymphocytic leukemia (CLL) is a heterogeneous disease. Whereas some patients have an indolent disease, others experience an aggressive course and early death. Our aim was to investigate if modifiable and non‐modifiable m
Externí odkaz:
https://doaj.org/article/4d902961c3344a49b8ed9eb4525c3db9
Publikováno v:
Balkan Journal of Medical Genetics, Vol 27, Iss 1, Pp 15-19 (2024)
Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. One of the best established CLL prognostic markers is the somatic hypermutational status of the IGHV gene which is a part of the immunoglobulin heavy chain variable region. Tec
Externí odkaz:
https://doaj.org/article/7fdbd389ec9e48c1afb15378e775a7f9
Autor:
Kateryna Khurdepa, Oksana Karnabeda
Publikováno v:
Galician Medical Journal, Vol 31, Iss 4 (2024)
Introduction. The TP53 gene encodes the p53 protein, crucial for DNA damage response, apoptosis, and cell cycle regulation. In chronic lymphocytic leukemia (CLL), TP53 loss due to 17p deletion or mutation leads to poor chemoimmunotherapy response and
Externí odkaz:
https://doaj.org/article/82f6e9413f4a454ba61680cd1455c644
Publikováno v:
Zhongliu Fangzhi Yanjiu, Vol 51, Iss 5, Pp 368-372 (2024)
Objective To investigate the clonal rearrangement characteristics and clinical application value of IGH gene in B-cell non-Hodgkin’s lymphoma (B-NHL). Methods Demographic and clinical data as well as IGH sequencing results of 55 patients with B-NHL
Externí odkaz:
https://doaj.org/article/bc8846c58ca441088c883b99aef5c086
Autor:
Carolina Muñoz-Novas, Isabel González-Gascón-y-Marín, Iñigo Figueroa, Laura Sánchez-Paz, Claudia Pérez-Carretero, Miguel Quijada-Álamo, Ana-Eugenia Rodríguez-Vicente, María-Stefania Infante, María-Ángeles Foncillas, Elena Landete, Juan Churruca, Karen Marín, Victoria Ramos, Alejandro Sánchez Salto, José-Ángel Hernández-Rivas
Publikováno v:
Global Medical Genetics, Vol 11, Iss 01, Pp 059-068 (2024)
Immunoglobulin heavy chain variable (IGHV) region mutations, TP53 mutation, fluorescence in situ hybridization (FISH), and cytogenetic analysis are the most important prognostic biomarkers used in chronic lymphocytic leukemia (CLL) patients in our da
Externí odkaz:
https://doaj.org/article/f70842a5f90747aca592d8371d7dfebd
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Mutated or unmutated immunoglobulin heavy chain (IGHV) gene is an important prognostic factor in chronic lymphocytic leukemia (CLL). However, a small fraction of patients with CLL are classified as borderline (BL)-IGHV. Few data are available on this
Externí odkaz:
https://doaj.org/article/677a8cb8c55849df9badb16a402f12d2
Autor:
Vera K. Schmid, Elias Hobeika
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
B cell antigen receptor (BCR) signaling is a key driver of growth and survival in both normal and malignant B cells. Several lines of evidence support an important pathogenic role of the BCR in chronic lymphocytic leukemia (CLL). The significant impr
Externí odkaz:
https://doaj.org/article/2bd4afbf33b645ff81da7c92582150f8
Autor:
Andrew M. Collins, Mats Ohlin, Martin Corcoran, James M. Heather, Duncan Ralph, Mansun Law, Jesus Martínez-Barnetche, Jian Ye, Eve Richardson, William S. Gibson, Oscar L. Rodriguez, Ayelet Peres, Gur Yaari, Corey T. Watson, William D. Lees
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
IntroductionAnalysis of an individual’s immunoglobulin (IG) gene repertoire requires the use of high-quality germline gene reference sets. When sets only contain alleles supported by strong evidence, AIRR sequencing (AIRR-seq) data analysis is more
Externí odkaz:
https://doaj.org/article/aa654cd36aa94db1a0e3b47ed8578d9f
Autor:
Wataru Morii, PhD, Koki Kasai, BS, Takako Nakamura, MSc, Daisuke Hayashi, MD, Monami Hara, MD, Tatsuhiko Naito, MD, PhD, Kyuto Sonehara, MD, PhD, Tatsuki Fukuie, MD, PhD, Mayako Saito-Abe, MD, PhD, Limin Yang, MD, PhD, Kiwako Yamamoto-Hanada, MD, PhD, Masami Narita, MD, PhD, Kazushi Maruo, PhD, Yukinori Okada, MD, PhD, Emiko Noguchi, MD, PhD, Yukihiro Ohya, MD, PhD
Publikováno v:
Journal of Allergy and Clinical Immunology: Global, Vol 2, Iss 2, Pp 100086- (2023)
Background: Allergic diseases are some of the most common diseases worldwide. Genome-wide association studies (GWASs) have been conducted to elucidate the genetic factors of allergic diseases. However, no GWASs for allergen component sensitization ha
Externí odkaz:
https://doaj.org/article/058964c6d2e64335bbff19fe91a7e2b9
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