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Akademický článek

IGFBP7 is a key component of the senescence-associated secretory phenotype (SASP) that induces senescence in healthy cells by modulating the insulin, IGF, and activin A pathways

Autor: Yesuf Siraj, Domenico Aprile, Nicola Alessio, Gianfranco Peluso, Giovanni Di Bernardo, Umberto Galderisi

Publikováno v: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-13 (2024)

Abstract Senescent cells exert their effects through the release of various factors, collectively referred to as the senescence-associated secretory phenotype (SASP). The SASP can induce senescence in healthy cells (secondary senescence), modulate im

Externí odkaz: https://doaj.org/article/7ca2260704324ce08536535e572d8132

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Akademický článek

IGFBP5 is released by senescent cells and is internalized by healthy cells, promoting their senescence through interaction with retinoic receptors

Autor: Nicola Alessio, Domenico Aprile, Gianfranco Peluso, Valeria Mazzone, Deanira Patrone, Giovanni Di Bernardo, Umberto Galderisi

Publikováno v: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-17 (2024)

Abstract Cells that are exposed to harmful genetic damage, either from internal or external sources, may undergo senescence if they are unable to repair their DNA. Senescence, characterized by a state of irreversible growth arrest, can spread to neig

Externí odkaz: https://doaj.org/article/e598facae67c43619dbd84bedf338c04

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Akademický článek

Association between IGF-1 and IGFBPs in Blood and Follicular Fluid in Dairy Cows Under Field Conditions

Autor: Christina Schiffers, Idil Serbetci, Kirsten Mense, Ana Kassens, Hanna Grothmann, Matthias Sommer, Christine Hoeflich, Andreas Hoeflich, Heinrich Bollwein, Marion Schmicke

Publikováno v: Animals, Vol 14, Iss 16, p 2370 (2024)

Insulin-like growth factor 1 (IGF-1) regulates dairy cow reproduction, while the paracrine IGF system locally influences fertility. In both systems, IGF-1 bioactivity is regulated through binding proteins (IGFBPs) inhibiting IGF-1 binding to its rece

Externí odkaz: https://doaj.org/article/3d5b572a09e7481ebabb53c2f5407865

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Akademický článek

Varying severity COVID-19 effects on the blood indicators of insulin-like growth factors family in patients with nonsmall cell lung cancer

Autor: O. I. Kit, E. M. Frantsiyants, D. A. Kharagezov, V. A. Bandovkina, N. D. Cheryarina, Yu. A. Pogorelova, Yu. N. Lazutin, A. G. Milakin, I. A. Leyman, O. N. Stateshny

Publikováno v: Южно-Российский онкологический журнал, Vol 4, Iss 2, Pp 6-15 (2023)

Purpose of the study. An analysis of IGF and their carrying proteins levels in blood serum of patients with non‑small cell lung cancer (NSCLC), depending on the severity of the previous COVID-19 infection.Materials and methods. 60 patients with his

Externí odkaz: https://doaj.org/article/bf380a9aa32f4c49a0accd0d894068bf

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Akademický článek

Expression characteristics and their functional role of IGFBP gene family in pan-cancer

Autor: Yingnan Liu, Shixuan Shen, Ziwei Yan, Lirong Yan, Hanxi Ding, Ang Wang, Qian Xu, Liping Sun, Yuan Yuan

Publikováno v: BMC Cancer, Vol 23, Iss 1, Pp 1-31 (2023)

Abstract Background Insulin-like growth factor binding proteins (IGFBPs) are critical regulators of the biological activities of insulin-like growth factors. The IGFBP family plays diverse roles in different types of cancer, which we still lack compr

Externí odkaz: https://doaj.org/article/f50964af5e8c420d99efed4a666a2f51

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Akademický článek

Indices of insulin-like growth factors family in the lung tissue of patients with non-small cell lung cancer after COVID-19 of various severity

Autor: O. I. Kit, E. M. Frantsiyants, D. A. Kharagezov, V. A. Bandovkina, N. D. Cheryarina, Yu. A. Pogorelova, Yu. N. Lazutin, A. G. Milakin, I. A. Leyman, O. N/ Stateshny

Publikováno v: Южно-Российский онкологический журнал, Vol 4, Iss 1, Pp 23-33 (2023)

Purpose of the study. An analysis of levels of IGF and their carrying proteins in lung tissues of cancer patients depending on the severity of the previous COVID-19 infection.Patients and methods. The study included 60 patients with histologically ve

Externí odkaz: https://doaj.org/article/96e876fb35504c8989555068255a6174

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Akademický článek

The Role of Insulin-like Growth Factor (IGF) System in the Corneal Epithelium Homeostasis—From Limbal Epithelial Stem Cells to Therapeutic Applications

Autor: Małgorzata Woronkowicz, Harry Roberts, Piotr Skopiński

Publikováno v: Biology, Vol 13, Iss 3, p 144 (2024)

The corneal epithelium, comprising three layers of cells, represents the outermost portion of the eye and functions as a vital protective barrier while concurrently serving as a critical refractive structure. Maintaining its homeostasis involves a co

Externí odkaz: https://doaj.org/article/4431b0629e554fec96842756001f51b9

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