IFI16, a nuclear innate immune DNA sensor, mediates epigenetic silencing of herpesvirus genomes by its association with H3K9 methyltransferases SUV39H1 and GLP

Autor: Arunava Roy, Anandita Ghosh, Binod Kumar, Bala Chandran

Publikováno v: eLife, Vol 8 (2019)

IFI16, an innate immune DNA sensor, recognizes the nuclear episomal herpes viral genomes and induces the inflammasome and interferon-β responses. IFI16 also regulates cellular transcription and act as a DNA virus restriction factor. IFI16 knockdown

Externí odkaz: https://doaj.org/article/d2b22504b8624dccbc098da947c3e0c6

IFI16, a nuclear innate immune DNA sensor, mediates epigenetic silencing of herpesvirus genomes by its association with H3K9 methyltransferases SUV39H1 and GLP.

Autor: Roy A; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, United States., Ghosh A; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, United States., Kumar B; Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, United States., Chandran B; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, United States.

Publikováno v: ELife [Elife] 2019 Nov 04; Vol. 8. Date of Electronic Publication: 2019 Nov 04.