Zobrazeno 1 - 10
of 178
pro vyhledávání: '"IEKUNI ICHIKAWA"'
Publikováno v:
Journal of Microbiology & Biology Education, Vol 15, Iss 2, Pp 155-158 (2014)
Changing patterns in collaborative research networks reflect a new geography of science that is increasingly shaped by interactions between established and emerging scientific powers, whose cultural and political diversity are now reflected in perhap
Externí odkaz:
https://doaj.org/article/38def81ebe994574a1c9775472f0f536
Autor:
Tomonori Hirose, Daisuke Satoh, Hidetake Kurihara, Chiho Kusaka, Hiroko Hirose, Kazunori Akimoto, Taiji Matsusaka, Iekuni Ichikawa, Tetsuo Noda, Shigeo Ohno
Publikováno v:
PLoS ONE, Vol 4, Iss 1, p e4194 (2009)
Glomerular visceral epithelial cells (podocytes) contain interdigitated processes that form specialized intercellular junctions, termed slit diaphragms, which provide a selective filtration barrier in the renal glomerulus. Analyses of disease-causing
Externí odkaz:
https://doaj.org/article/34963a7f651a4c7bb23169ef0133c434
Autor:
Eric Mah, Ping Sun, In Jae Lee, Surendra S Shastri, Ovid J.L. Tzeng, Frederick K. S. Leung, Mai Har Sham, Theresa Sawicka, Daniel P Barr, Danny Chan, Michael W. Kalichman, Iekuni Ichikawa, Paul Taylor, El-Nasir Lalani, Prasit Palittapongarnpim, Tony Mayer, Zoë Hammatt, Susan Garfinkel
Publikováno v:
Account Res
In 2017, the University of Hong Kong and the University of California San Diego co-hosted the first Asian meeting of the recently formed Asia Pacific Research Integrity (APRI) network in Hong Kong. Aligned with planning meetings in 2015 and 2016 fund
Autor:
Iekuni Ichikawa, Ellen Wright Clayton
Publikováno v:
Accountability in Research
Recently, two Japanese clinical studies of antihypertensive drugs, supported by pharmaceutical companies and published in the Lancet by groups of Japanese investigators, were later withdrawn (Editors of the Lancet, 2009, 2013a). Four other studies of
Autor:
Masahiro Okabe, Akira Nishiyama, Yoichi Miyazaki, Iekuni Ichikawa, Takashi Yokoo, Fumio Niimura, Ira Pastan, Taiji Matsusaka
Publikováno v:
American Journal of Physiology-Renal Physiology. 308:F932-F937
The renal tissue renin-angiotensin system is activated in chronic kidney diseases. We previously demonstrated that intrarenal ANG II is synthesized primarily from liver-derived angiotensinogen filtered through the glomerulus and that podocyte injury
Publikováno v:
Kidney International. 85:1068-1077
Intrarenal angiotensin II is increased in kidney diseases independently of plasma angiotensin II and is thought to promote progressive deterioration of renal architecture. Here we investigated the mechanism of enhanced renal angiotensin II generation
Autor:
Akira Oka, Takashi Hirukawa, Taiji Matsusaka, Satoshi Umemura, Hidetoshi Inoko, Nobuhito Hirawa, Sanae Saka, Masafumi Fukagawa, Takatoshi Kakuta, Qiong Wu, Kaichiro Sawada, Iekuni Ichikawa, Masayuki Endoh
Publikováno v:
Nephron Extra
Nephron Extra, Vol 4, Iss 1, Pp 70-81 (2014)
Nephron Extra, Vol 4, Iss 1, Pp 70-81 (2014)
Background/Aims:TSPAN8 encoding tetraspanin-8 was identified as a candidate gene for immunoglobulin A nephropathy (IgAN) by a genome-wide association study using microsatellites in the Japanese population. Tetraspanin-8 is a cell surface protein that
Autor:
Ji Ma, Jianyong Zhong, Daniel S. Perrien, Haichun Yang, Iekuni Ichikawa, Valentina Kon, Agnes B. Fogo
Publikováno v:
Pediatric research
Background Regression is an important process in normal development of many organs. In the present study, we investigated whether glomerular regression occurs after normal glomerulogenesis and determined the time course for this process. Methods Glom
Publikováno v:
Nephron Extra
Nephron Extra, Vol 2, Iss 1, Pp 17-26 (2012)
Nephron Extra, Vol 2, Iss 1, Pp 17-26 (2012)
Background: We previously showed that angiotensin type 1 receptor (AT1) blocker (ARB) attenuates glomerular injury in Nphs1-hCD25 (NEP25) transgenic mice, a model of selective podocyte injury. However, subsequent studies in NEP25 mice with podocyte-s
Autor:
Suguru Yamamoto, Yiqin Zuo, Ryohei Kaseda, Patricia G. Yancey, Iekuni Ichikawa, Valentina Kon, Agnes B. Fogo, Sergio Fazio, MacRae F. Linton, Li-Jun Ma
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 31:2856-2864
Objective— Angiotensin II is a major determinant of atherosclerosis. Although macrophages are the most abundant cells in atherosclerotic plaques and express angiotensin II type 1 receptor (AT1), the pathophysiologic role of macrophage AT1 in athero