Zobrazeno 1 - 10
of 29
pro vyhledávání: '"IDR, intrinsically disordered region"'
Autor:
Paul Gale
Publikováno v:
Microbial Risk Analysis
Highlights • Affinity of virus binding to host cell modelled as a function of temperature and number of GP/Cr contacts. • Enthalpy-driven and entropy-driven GP/Cr contacts have opposite effects on temperature sensitivity. • Model for effect of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b1444236eec858223f874cbdedfbb2
http://europepmc.org/articles/PMC7104215
http://europepmc.org/articles/PMC7104215
Autor:
Saikat Bhattacharya, Michaella J. Levy, Michael P. Washburn, Jeffrey J. Lange, Laurence Florens, Jerry L. Workman
Publikováno v:
The Journal of Biological Chemistry
SETD2 is an important methyltransferase that methylates crucial substrates such as histone H3, tubulin, and STAT1 and also physically interacts with transcription and splicing regulators such as Pol II and various hnRNPs. Of note, SETD2 has a functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7440a573ed0fc2395bff62aede8af8be
https://pubmed.ncbi.nlm.nih.gov/34391778
https://pubmed.ncbi.nlm.nih.gov/34391778
Publikováno v:
The Journal of Biological Chemistry
The concept of liquid–liquid phase separation (LLPS) has emerged as an intriguing mechanism for the organization of membraneless compartments in cells. The alcohol 1,6-hexanediol is widely used as a control to dissolve LLPS assemblies in phase sepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7969621984bc4a26a43efd29a43fdb29
https://pubmed.ncbi.nlm.nih.gov/33814344
https://pubmed.ncbi.nlm.nih.gov/33814344
Autor:
Sailen Barik
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 1884-1890 (2020)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract
Highlights • The nucleocapsid protein (N) is an essential structural protein of the coronavirus. • N protein binds RNA and also interacts with several proteins in its multitasking role. • The central region of N contains
Highlights • The nucleocapsid protein (N) is an essential structural protein of the coronavirus. • N protein binds RNA and also interacts with several proteins in its multitasking role. • The central region of N contains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f0092bb6bab5a3faa1a055d14719969
https://pubmed.ncbi.nlm.nih.gov/32765822
https://pubmed.ncbi.nlm.nih.gov/32765822
Autor:
Kim, Do-Hyoung, Han, Kyou-Hoon
Publikováno v:
Molecules and Cells
Intrinsically disordered proteins (IDPs) are highly unorthodox proteins that do not form three-dimensional structures under physiological conditions. The discovery of IDPs has destroyed the classical structure-function paradigm in protein science, 3-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9deba2e63a5728078494d517f718f052
http://europepmc.org/articles/PMC6199570
http://europepmc.org/articles/PMC6199570
Manganese promotes α-synuclein amyloid aggregation through the induction of protein phase transition
Publikováno v:
The Journal of Biological Chemistry
α-Synuclein (α-Syn) is the major protein component of Lewy bodies, a key pathological feature of Parkinson’s disease (PD). The manganese ion Mn2+ has been identified as an environmental risk factor of PD. However, it remains unclear how Mn2+ regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d4e4b1349f879b0af226bdc274af50
https://doi.org/10.1016/j.jbc.2021.101469
https://doi.org/10.1016/j.jbc.2021.101469
Autor:
Nicholas C. Fitzkee, Elisia A. Paiz, John J. Correia, Jeffre H. Allen, Loren E. Hough, Steven T. Whitten
Publikováno v:
The Journal of Biological Chemistry
The complex cellular milieu can spontaneously demix, or phase separate, in a process controlled in part by intrinsically disordered (ID) proteins. A protein's propensity to phase separate is thought to be driven by a preference for protein–protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883efbb92e2e157405838e8c563ed1cb
https://doi.org/10.1016/j.jbc.2021.101343
https://doi.org/10.1016/j.jbc.2021.101343
Publikováno v:
The Journal of biological chemistry, vol 297, iss 4
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Membraneless organelles (MLOs) are vital and dynamic reaction centers in cells that compartmentalize the cytoplasm in the absence of a membrane. Multivalent interactions between protein low-complexity domains contribute to MLO organization. Previousl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d419d0f6f4d0e8ebfba58c330caae1f
https://doi.org/10.1016/j.jbc.2021.101194
https://doi.org/10.1016/j.jbc.2021.101194
Autor:
Chan Zhao, Chen Guo, Wenfei Pan, Ying Sun, Yuqun Xu, Cong Yu, Xingqiao Xie, Zhiyi Wei, Yanyan Ding
Publikováno v:
The Journal of Biological Chemistry
Nephrotic syndrome (NS) is a common kidney disorder caused by dysfunction of the glomerular filtration barrier. Some genetic mutations identified in NS patients cause amino acid substitutions of kidney ankyrin repeat-containing (KANK) proteins, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba1c330d62edfb55cf9670150864b3e9
https://doi.org/10.1016/j.jbc.2021.100958
https://doi.org/10.1016/j.jbc.2021.100958
Autor:
Andras Lukacs, András Kengyel, Elek Telek, Henriett Halász, Kristof Karadi, Beáta Bugyi, Miklós Nyitrai, József Kardos, Zsuzsanna Fekete
Publikováno v:
The Journal of Biological Chemistry
The lesser-known unconventional myosin 16 protein is essential in proper neuronal functioning and has been implicated in cell cycle regulation. Its longer Myo16b isoform contains a C-terminal tail extension (Myo16Tail), which has been shown to play a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ea193c50307e98951fb7f431981c6b
https://doi.org/10.1016/j.jbc.2021.100716
https://doi.org/10.1016/j.jbc.2021.100716