Zobrazeno 1 - 10
of 1 697
pro vyhledávání: '"IDO1"'
Autor:
Pratyasha Sarangi
Publikováno v:
Cancer Pathogenesis and Therapy, Vol 2, Iss 4, Pp 246-255 (2024)
Breast cancer (BC) contributes greatly to global cancer incidence and is the main cause of cancer-related deaths among women globally. It is a complex disease characterized by numerous subtypes with distinct clinical manifestations. Immune checkpoint
Externí odkaz:
https://doaj.org/article/ccc207d8cb414e6888ef9ddb7ba48e81
Autor:
Shirong Ding, Ruozhu Yang, Jiahao Meng, Xinyu Guan, Yue Hong, Jiachi Xu, Limeng Qu, Jingfen Ji, Wenjun Yi, Qiongyan Zou, Qian Long
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Indoleamine 2,3-dioxygenase 1 (IDO1) plays an important role in the initiation and progression of breast cancer. DNA promoter methylation status has the potential to be used as a biomarker for predicting the response to immunotherapy. This s
Externí odkaz:
https://doaj.org/article/9950e7b80f2d4d52be9e7b914f1f83fe
Publikováno v:
International Journal of Nanomedicine, Vol Volume 19, Pp 8847-8882 (2024)
Kehua Jiang,1 Qing Wang,1 Xiao-Long Chen,1 Xiaodong Wang,1 Xiaoya Gu,1 Shuangshuang Feng,1 Jian Wu,2 Haojie Shang,2 Xiaozhuo Ba,2 Yanlong Zhang,1 Kun Tang2 1Department of Urology, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, People’s R
Externí odkaz:
https://doaj.org/article/7d7fd87d778e4eaca36c35c3fe7a7f08
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background Glioblastoma is an aggressive brain cancer, usually of unknown etiology, and with a very poor prognosis. Survival from diagnosis averages only 3 months if left untreated and this only increases to 12–15 months upon treatment. Tr
Externí odkaz:
https://doaj.org/article/222c2913c9164cf8b68cb094bfbedce6
Autor:
Irfan Cicin, Elizabeth R. Plimack, Howard Gurney, Raya Leibowitz, Boris Y. Alekseev, Francis X. Parnis, Avivit Peer, Andrea Necchi, Joaquim Bellmunt, Hiroyuki Nishiyama, Jason Clark, Mihaela Munteanu, Ritesh Kataria, Calvin Jia, Thomas Powles, Cora N. Sternberg
Publikováno v:
BMC Cancer, Vol 23, Iss S1, Pp 1-11 (2024)
Abstract Background Indoleamine 2,3-dioxygenase 1 (IDO1) levels correlate with poor outcomes in urothelial carcinoma (UC). IDO1 and programmed death-ligand 1 (PD-L1) are often co-expressed. Epacadostat is a potent and highly selective inhibitor of ID
Externí odkaz:
https://doaj.org/article/263d9199baf8485699909ce6591e41d9
Autor:
Primo N. Lara, Luis Villanueva, Carolina Ibanez, Mustafa Erman, Jae Lyun Lee, Daniel Heinrich, Oleg Nikolaevich Lipatov, Craig Gedye, Erhan Gokmen, Alejandro Acevedo, Andrey Semenov, Se Hoon Park, Rustem Airatovich Gafanov, Fatih Kose, Mark Jones, Xiaoqi Du, Mihaela Munteanu, Rodolfo Perini, Toni K. Choueiri, Robert J. Motzer
Publikováno v:
BMC Cancer, Vol 23, Iss S1, Pp 1-12 (2024)
Abstract Background Immunotherapy-based combinations have emerged as standard therapies for patients with metastatic renal cell carcinoma (mRCC). Pembrolizumab, a PD-1 inhibitor, combined with epacadostat, an indoleamine 2,3-deoxygenase 1 selective i
Externí odkaz:
https://doaj.org/article/f27c30f1bd8e406580492b76ee1bb216
Autor:
Andrea Necchi, Michiel S. Van der Heijden, Dmytro Trukhin, Avivit Peer, Howard Gurney, Boris Y. Alekseev, Francis X. Parnis, Raya Leibowitz, Maria De Santis, Petros Grivas, Jason Clark, Mihaela Munteanu, Ritesh Kataria, Calvin Jia, Arjun V. Balar, Ronald de Wit
Publikováno v:
BMC Cancer, Vol 23, Iss S1, Pp 1-11 (2024)
Abstract Background Indoleamine 2,3- dioxygenase 1 (IDO1) is an immunosuppressive enzyme that has been correlated with shorter disease-specific survival in patients with urothelial carcinoma (UC). IDO1 may counteract the antitumor effects of immune c
Externí odkaz:
https://doaj.org/article/37a2f0fcea5140a684940d22b18e5a1a
Autor:
Wuyi Liu, Huyue Zhou, Wenjing Lai, Changpeng Hu, Qiaoling Wang, Chengsha Yuan, Chunmei Luo, Mengmeng Yang, Min Hu, Rong Zhang, Guobing Li
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Artesunate (ART), a natural product isolated from traditional Chinese plant Artemisia annua, has not been extensively explored for its anti-melanoma properties. In our study, we found that ART inhibited melanoma cell proliferation and induce
Externí odkaz:
https://doaj.org/article/957fe5ade6f84d5fb258d22286eb1263
Autor:
Laurie L. Kenney, Rebecca Suet-Yan Chiu, Michelle N. Dutra, Alexandra Wactor, Chris Honan, Lukas Shelerud, Joshua J. Corrigan, Kelly Yu, Joseph D. Ferrari, Kate L. Jeffrey, Eric Huang, Paul L. Stein
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101717- (2024)
Summary: Indoleamine-2,3-dioxygenase (IDO)1 degrades tryptophan, obtained through dietary intake, into immunoregulatory metabolites of the kynurenine pathway. Deficiency or blockade of IDO1 results in the enhancement of autoimmune severity in rodent
Externí odkaz:
https://doaj.org/article/02d2479310034e2f931923d7ec2377fe
Autor:
Yaojun Peng, Lingxiong Wang, Juan Yang, Qiyan Wu, Xiaoxuan Sun, Jinying Zhang, Yanju Yu, Liping Zhang, Jie Gao, Qing Zhou, Haiyan Zhu, Fan Yin
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundInhibition of indolamine-2,3-dioxygenase 1 (IDO1) has been proposed as a promising strategy for cancer immunotherapy; however, it has failed in clinical trials. Macrophages in the tumor microenvironment (TME) contribute to immune escape and
Externí odkaz:
https://doaj.org/article/f743289e7a1d4d01a4a80a071933459b