IDH2 mutation accelerates TPO‐induced myelofibrosis with enhanced S100a8/a9 and NFκB signaling in vivo

Autor: Chien‐Chin Lin, Chi‐Yuan Yao, Yu‐Hung Wang, Yueh‐Chwen Hsu, Chang‐Tsu Yuan, Tsung‐Chih Chen, Chia‐Lang Hsu, Sze‐Hwei Lee, Jhih‐Yi Lee, Pin‐Tsen Shih, Chein‐Jun Kao, Po‐Han Chuang, Yuan‐Yeh Kuo, Hsin‐An Hou, Wen‐Chien Chou, Hwei‐Fang Tien

Publikováno v: eJHaem, Vol 5, Iss 4, Pp 738-748 (2024)

Abstract Introduction IDH2 mutation is an unfavorable prognostic factor in patients with primary myelofibrosis (PMF) but its effect on myelofibrosis (MF) remains largely unclear. Methods In this study, we aimed to elucidate the roles of IDH2 mutation

Externí odkaz: https://doaj.org/article/fa92d941b488439f9510b04086ba0152

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Differentiation Syndrome in a Patient With NSCLC Harboring IDH2 Mutation Treated With Enasidenib: Case Report

Autor: Bhoomika Sukhadia, MD, Dean Tan, BA, BS, Youjin Oh, MD, Zunairah Shah, MD, Young Kwang Chae, MD, MPH, MBA

Publikováno v: JTO Clinical and Research Reports, Vol 5, Iss 10, Pp 100520- (2024)

IDH2 gain-of-function mutations cause DNA hypermethylation interfering with cellular differentiation and are linked to poor disease outcomes in NSCLC. IDH2-inhibitor enasidenib is approved for refractory acute myeloid leukemia but has been associated

Externí odkaz: https://doaj.org/article/19831a8ca6a14d10bc58dd48f0004a12

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IDH2 mutation accelerates TPO-induced myelofibrosis with enhanced S100a8/a9 and NFκB signaling in vivo.

Autor: Lin CC; Department of Laboratory Medicine National Taiwan University Hospital Taipei Taiwan.; Division of Hematology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine National Taiwan University Taipei Taiwan., Yao CY; Department of Laboratory Medicine National Taiwan University Hospital Taipei Taiwan.; Division of Hematology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan., Wang YH; Division of Hematology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan., Hsu YC; Department of Laboratory Medicine National Taiwan University Hospital Taipei Taiwan., Yuan CT; Graduate Institute of Clinical Medicine, College of Medicine National Taiwan University Taipei Taiwan.; Department of Pathology Graduate Institute of Oncology College of Medicine National Taiwan University Taipei Taiwan.; Department of Pathology National Taiwan University Cancer Center Taipei Taiwan., Chen TC; Graduate Institute of Clinical Medicine, College of Medicine National Taiwan University Taipei Taiwan.; Division of Hematology and Medical Oncology Department of Internal Medicine Taichung Veterans General Hospital Taipei Taiwan., Hsu CL; Department of Medical Research National Taiwan University Cancer Center Taipei Taiwan., Lee SH; Division of Cellular Therapy Department of Integrated Diagnostics and Therapeutics National Taiwan University Hospital Taipei Taiwan., Lee JY; Department of Laboratory Medicine National Taiwan University Hospital Taipei Taiwan., Shih PT; Department of Laboratory Medicine National Taiwan University Hospital Taipei Taiwan., Kao CJ; Department of Laboratory Medicine National Taiwan University Hospital Taipei Taiwan., Chuang PH; Department of Laboratory Medicine National Taiwan University Hospital Taipei Taiwan., Kuo YY; Tai-Cheng Stem Cell Therapy Center National Taiwan University Taipei Taiwan., Hou HA; Division of Hematology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan., Chou WC; Department of Laboratory Medicine National Taiwan University Hospital Taipei Taiwan.; Division of Hematology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan., Tien HF; Division of Hematology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan.; Division of Hematology and Medical Oncology Department of Internal Medicine Far Eastern Memorial Hospital New Taipei Taiwan.

Publikováno v: EJHaem [EJHaem] 2024 Jul 28; Vol. 5 (4), pp. 738-748. Date of Electronic Publication: 2024 Jul 28 (Print Publication: 2024).