Mathematical modeling of PDGF-driven glioma reveals the dynamics of immune cells infiltrating into tumors

Autor: Sarah Holte, Jianjun Paul Tian, Frank Szulzewsky, Xianyi Zeng, Eric C. Holland, Ben Niu, Tuan Anh Phan

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 9, Pp 323-332 (2020)
Neoplasia (New York, N.Y.)

Background: Tumor-infiltrated immune cells compose a significant component of many cancers. They have been observed to have contradictory impacts on tumors. Although the primary reasons for these observations remain elusive, it is important to unders

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2021e2b4c96d64bffc23e51a393dd57f
http://www.sciencedirect.com/science/article/pii/S1476558620301226

Selenium-dependent metabolic reprogramming during inflammation and resolution

Autor: Philip B. Smith, Arvind M. Korwar, Ayaan Hossain, Tai Jung Lee, Bradley A. Carlson, Ashley E. Shay, Venkatesha Basrur, Howard M. Salis, K. Sandeep Prabhu, Andrew D. Patterson, Kevin P. Conlon

Publikováno v: The Journal of Biological Chemistry

Trace element selenium (Se) is incorporated as the 21st amino acid, selenocysteine, into selenoproteins through tRNA[Ser]Sec. Selenoproteins act as gatekeepers of redox homeostasis and modulate immune function to effect anti-inflammation and resoluti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da3b13128186330a568d97fcebab8ca
https://doi.org/10.1101/2021.01.16.426951

Lactate and glutamine support NADPH generation in cancer cells under glucose deprived conditions

Autor: Minfeng Ying, Xun Hu, Siying Zeng, Xiaobing Zhu, Limeng Cai, Duo You

Publikováno v: Redox Biology
Redox Biology, Vol 46, Iss, Pp 102065-(2021)

Although glucose, through pentose phosphate pathway (PPP), is the main source to generate NADPH, solid tumors are often deprived of glucose, hence alternative metabolic pathways to maintain NADPH homeostasis in cancer cells are required. Here, we rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500167b4da9159d9b7d996c882afcde9
https://doi.org/10.1016/j.redox.2021.102065

Hyperpolarized 13C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring

Autor: Chloé Najac, Pavithra Viswanath, Pia Eriksson, Sabrina M. Ronen, Charles Chesnelong, Michael D. Blough, J. Gregory Cairncross, H. Artee Luchman, Marina Radoul, Myriam M. Chaumeil

Publikováno v: NeuroImage: Clinical, Vol 12, Iss C, Pp 180-189 (2016)
NeuroImage : Clinical

Metabolic imaging of brain tumors using 13C Magnetic Resonance Spectroscopy (MRS) of hyperpolarized [1-13C] pyruvate is a promising neuroimaging strategy which, after a decade of preclinical success in glioblastoma (GBM) models, is now entering clini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34e02c24aae0d84bc1de9bcb234bbbd
http://www.sciencedirect.com/science/article/pii/S2213158216301164

Transcortical insular glioma resection: clinical outcome and predictors.

Autor: Hameed NUF; 1Glioma Surgery Division, Neurosurgery Department of Huashan Hospital, Fudan University., Qiu T; 1Glioma Surgery Division, Neurosurgery Department of Huashan Hospital, Fudan University., Zhuang D; 1Glioma Surgery Division, Neurosurgery Department of Huashan Hospital, Fudan University., Lu J; 1Glioma Surgery Division, Neurosurgery Department of Huashan Hospital, Fudan University., Yu Z; 1Glioma Surgery Division, Neurosurgery Department of Huashan Hospital, Fudan University., Wu S; 1Glioma Surgery Division, Neurosurgery Department of Huashan Hospital, Fudan University., Wu B; 1Glioma Surgery Division, Neurosurgery Department of Huashan Hospital, Fudan University., Zhu F; 1Glioma Surgery Division, Neurosurgery Department of Huashan Hospital, Fudan University., Song Y; 2Department of Biostatistics, Medical School of Shanghai Jiaotong University; and., Chen H; 3Department of Pathology, Huashan Hospital, Fudan University, Shanghai, China., Wu J; 1Glioma Surgery Division, Neurosurgery Department of Huashan Hospital, Fudan University.

Publikováno v: Journal of neurosurgery [J Neurosurg] 2018 Oct 19; Vol. 131 (3), pp. 706-716. Date of Electronic Publication: 2018 Oct 19 (Print Publication: 2019).