Zobrazeno 1 - 10
of 337
pro vyhledávání: '"ICK"'
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The structure-function and optimization studies of NaV-inhibiting spider toxins have focused on developing selective inhibitors for peripheral pain-sensing NaV1.7. With several NaV subtypes emerging as potential therapeutic targets, structure-functio
Externí odkaz:
https://doaj.org/article/fd8936cba0884ae2b080c326a1baaec7
Autor:
Luis Fernando Díaz-Peña, Torres-Ortiz Daniela, Manuel B. Aguilar, Enoch Luis, Fernando Lazcano-Pérez, Roberto Arreguín-Espinosa, Arturo Hernandez-Cruz, César Ibarra-Alvarado, Alejandro García-Arredondo
Publikováno v:
Toxicon: X, Vol 18, Iss , Pp 100151- (2023)
Venoms from tarantulas contain low molecular weight vasodilatory compounds whose biological action is conceived as part of the envenomation strategy due to its propagative effects. However, some properties of venom-induced vasodilation do not match t
Externí odkaz:
https://doaj.org/article/9d6f18d734924adb8675b7c7a15089da
Akademický článek
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Autor:
Zhao, Ruiming, Kennedy, Kelleigh, De Blas, Gerardo A., Orta, Gerardo, Pavarotti, Martín A., Arias, Rodolfo J., de la Vega-Beltrán, José Luis, Li, Qufei, Dai, Hui, Perozo, Eduardo, Mayorga, Luis S., Darszon, Alberto, Goldstein, Steve A. N.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2018 Dec 01. 115(50), E11847-E11856.
Externí odkaz:
https://www.jstor.org/stable/26580198
Autor:
Yashad Dongol, Phil M. Choi, David T. Wilson, Norelle L. Daly, Fernanda C. Cardoso, Richard J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Given the important role of voltage-gated sodium (NaV) channel-modulating spider toxins in elucidating the function, pharmacology, and mechanism of action of therapeutically relevant NaV channels, we screened the venom from Australian theraphosid spe
Externí odkaz:
https://doaj.org/article/9ae45fd9c19649b6ae84254c5db1a14b
Autor:
Igor E. Kasheverov, Yulia A. Logashina, Fedor D. Kornilov, Vladislav A. Lushpa, Ekaterina E. Maleeva, Yuliya V. Korolkova, Jinpeng Yu, Xiaopeng Zhu, Dongting Zhangsun, Sulan Luo, Klara Stensvåg, Denis S. Kudryavtsev, Konstantin S. Mineev, Yaroslav A. Andreev
Publikováno v:
Toxins, Vol 15, Iss 1, p 28 (2022)
Nicotinic acetylcholine receptors (nAChRs) play an important role in the functioning of the central and peripheral nervous systems, and other organs of living creatures. There are several subtypes of nAChRs, and almost all of them are considered as p
Externí odkaz:
https://doaj.org/article/2e0a0500fc45433fb23a2f096657d870
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8121 (2022)
The primary cilium provides cell sensory and signaling functions. Cilia structure and function are regulated by ciliogenesis-associated kinase 1 (CILK1). Ciliopathies caused by CILK1 mutations show longer cilia and abnormal Hedgehog signaling. Our st
Externí odkaz:
https://doaj.org/article/2babbbfc0fcc46438d5c0f354a5c33d4
Akademický článek
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