Anti–PD-1 in Combination With Trametinib Suppresses Tumor Growth and Improves Survival of Intrahepatic Cholangiocarcinoma in Mice

Autor: Chi Ma, Benjamin L. Green, Benjamin Ruf, Mayank Tandon, Laurence P. Diggs, John C. McVey, Simon Wabitsch, Bernd Heinrich, Tim F. Greten, Qianfei Zhang, Justin D. McCallen

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 1166-1178 (2021)

Background & Aims Intrahepatic cholangiocarcinoma (iCCA) accounts for a fraction of primary liver cancers but has a 5-year survival rate of only 10%. Immune checkpoint inhibitors are effective in treating many solid cancers, but immune checkpoint inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcfa0235fd2025edb0051c54423904e0
http://europepmc.org/articles/PMC8413239

cAMP Stimulates SLC26A3 Activity in Human Colon by a CFTR-Dependent Mechanism That Does Not Require CFTR Activity

Autor: Jianyi Yin, Chung Ming Tse, Jerrold R. Turner, Alan S. Verkman, Mark Donowitz, Ruxian Lin, Varsha Singh, Rafiquel Sarker

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 3, Pp 641-653 (2019)
Cellular and molecular gastroenterology and hepatology, vol 7, iss 3
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims: SLC26A3 (DRA) is an electroneutral Cl-/HCO3- exchanger that is present in the apical domain of multiple intestinal segments. An area that has continued to be poorly understood is related to DRA regulation in acute adenosine 3′,5�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693b1f8995b6aa490d3c263bd4b61549
https://doi.org/10.1016/j.jcmgh.2019.01.002

Inhibitors of Arg-Gly-Asp-Binding Integrins Reduce Development of Pancreatic Fibrosis in Mice

Autor: Barbara Ulmasov, Jinping Lai, Vladimir Monastyrskiy, Matthew P. Yates, Brent A. Neuschwander-Tetri, Michael J. Prinsen, David W. Griggs, Peter G. Ruminski, Jonathan Oliva, Trisha Bhat

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 2, Iss 4, Pp 499-518 (2016)

Background & Aims: Pancreatic stellate cells (PSCs) regulate the development of chronic pancreatitis (CP) and are activated by the cytokine transforming growth factor β (TGFB). Integrins of the αv family promote TGFB signaling in mice, probably

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a0e27c59dc078b909d7b2054b436a01

Convection-enhanced delivery of sorafenib and suppression of tumor progression in a murine model of brain melanoma through the inhibition of signal transducer and activator of transcription 3.

Autor: Zou Z; Division of Neurosurgery, Department of Surgery, City of Hope National Medical Center, Duarte, California; and., Yin Y; Division of Neurosurgery, Department of Surgery, City of Hope National Medical Center, Duarte, California; and., Lin J; Division of Neurosurgery, Department of Surgery, City of Hope National Medical Center, Duarte, California; and., Hsu LC; Division of Neurosurgery, Department of Surgery, City of Hope National Medical Center, Duarte, California; and., Brandon VL; Division of Neurosurgery, Department of Surgery, City of Hope National Medical Center, Duarte, California; and., Yang F; Division of Neurosurgery, Department of Surgery, City of Hope National Medical Center, Duarte, California; and., Jove R; Division of Neurosurgery, Department of Surgery, City of Hope National Medical Center, Duarte, California; and., Jandial R; Division of Neurosurgery, Department of Surgery, City of Hope National Medical Center, Duarte, California; and., Li G; Faculty of Health Sciences, University of Macau, China., Chen MY; Division of Neurosurgery, Department of Surgery, City of Hope National Medical Center, Duarte, California; and.

Publikováno v: Journal of neurosurgery [J Neurosurg] 2016 May; Vol. 124 (5), pp. 1310-8. Date of Electronic Publication: 2015 Nov 06.