A3 Adenosine and P2X7 Purinergic Receptors as New Targets for an Innovative Pharmacological Therapy of Malignant Pleural Mesothelioma

Autor: Fabrizio Vincenzi, John Charles Rotondo, Silvia Pasquini, Francesco Di Virgilio, Katia Varani, Mauro Tognon

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

Human malignant pleural mesothelioma (MPM) is a rare, but aggressive tumor of the serosal cavities whose 5-year survival rate is 15%. At present, there are no effective therapies for MPM. Although recent findings suggest that A3 adenosine (A3AR) and

Externí odkaz: https://doaj.org/article/d91d9ef72ea744a38bbe08ea32028683

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A3 receptor agonist modulates IL-1β hippocampus levels in a rat model of neuropathic pain

Autor: Cioato, Stefania Giotti, Medeiros, Liciane Fernandes, Lopes, Bettega Costa, Medeiros, Helouise Richardt, Caumo, Wolnei, Roesler, Rafael, Torres, Iraci LS

Publikováno v: Clinical & Biomedical Research; Vol. 42 No. 2 (2022)
Clinical and Biomedical Research; v. 42 n. 2 (2022)
Clinical and Biomedical Research
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS

Introduction: Considering the lack of specific treatments to neuropathic pain, this study aimed to evaluate the effect of a single dose adenosine A3 receptor IB-MECA in the inflammatory and neurotrophic parameters of rats submitted to a neuropathic p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ab661e5ad55c9e0b59ab66a482f8dfb
https://doi.org/10.22491/2357-9730.116706

Adenosine receptor 2B activity promotes autonomous growth, migration as well as vascularization of head and neck squamous cell carcinoma cells

Autor: Alexey Ushmorov, Patrick J. Schuler, Simon Laban, Amelie Mahr, Cornelia Brunner, Thomas K. Hoffmann, Robert Drees, Ralf Marienfeld, Johannes Doescher, Jens Greve, Marie-Nicole Theodoraki, Ninel Azoitei, E Goldberg-Bockhorn, Felicia Frank, Max Wilkat, Johannes Dünser, Hanna Bast, Magnus Brhel

Publikováno v: International journal of cancerReferences. 147(1)

Adenosine is a signaling molecule that exerts dual effects on tumor growth: while it inhibits immune cell function and thereby prevents surveillance by the immune system, it influences tumorigenesis directly via activation of adenosine receptors on t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355ff2eb35da8bb44cc5918663239ce4
https://pubmed.ncbi.nlm.nih.gov/31846065