Zobrazeno 1 - 10
of 235
pro vyhledávání: '"I.W. Kellaway"'
Autor:
I.W. Kellaway, M.D Abd El-Hameed
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 44:53-60
Microspheres of hydrophilic polymers were prepared by the w/o emulsification solvent evaporation technique with a potential application as drug carriers for nasal administration by insufflation. The microspheres had a median particle size of 38 + 1.7
Publikováno v:
International Journal of Pharmaceutics. 148:55-61
In vitro 17β-estradiol release from controlled-release microspheres intended for intra-muscular administration was investigated using a rotating bottle apparatus. Prior to intra-muscular administration of 17β-estradiol loaded microspheres the in vi
Autor:
B. Delgado-Charro, José Blanco-Méndez, N. García-González, H. Blanco-Fuente, I.W. Kellaway, Francisco J. Otero-Espinar, S. Anguiano-Igea
Publikováno v:
International Journal of Pharmaceutics. 100:65-70
We evaluated the effects of polyacrylic acid (PAA) molecular weight and crosslinking agent (sucrose) concentration on swelling and drug (metoclopramide) release characteristics of PAA (Carbopol) hydrogels. Both factors, and the interactions between t
Autor:
Francisco J. Otero-Espinar, S. Anguiano-Igea, B. Delgado-Charro, N. García-González, José Blanco-Méndez, H. Blanco-Fuente, I.W. Kellaway
Publikováno v:
International Journal of Pharmaceutics. 100:25-31
We evaluated the effects of polyacrylic acid (PAA) molecular weight and crosslinking agent (β-cyclodextrin) concentration on swelling and drug (metoclopramide) release characteristics of PAA hydrogels. Both factors, and the interactions between them
Publikováno v:
International Journal of Pharmaceutics. 83:139-145
Photon correlation spectroscopy was used to study the decrease in diffusion coefficient of the gelatin molecule during the early stages of gelation. The rate of gelation was found to depend on gelatin source, but the kinetic pathway appeared similar
Publikováno v:
Pharmaceutical Research. :1137-1144
Association of Carbopol 934P and Carbopol 1342 (a hydrophobic modified Carbopol resin) with phospholipid vesicles was assessed by photon correlation spectroscopy and microelectrophoresis at pH 7.4 and 5. The precorneal clearance of the polymer-coated
Publikováno v:
International Journal of Pharmaceutics. 73:185-190
Photon correlation spectroscopy was used to measure the hydrodynamic thickness of gelatin films adsorbed onto latex particles. When prepared in solutions of distilled water acid ossein gelatins showed less dimensional variation over the pH range than
Publikováno v:
International Journal of Pharmaceutics. 71:147-152
The surface active characteristics of gelatin molecules were studied by measuring the surface tension of dilute limed and acid osscin gelatin solutions. A predicted response to increases in temperature and concentration was obtained. The pH variation
Publikováno v:
Pharmaceutical Research. :1039-1043
The potential of a mucoadhesive polymer as an ophthalmic vehicle is evaluated within the rabbit. Precorneal clearance of a mucoadhesive polymer solution (Carbopol 934P) is compared to that of an equiviscous nonmucoadhesive poly(vinyl alcohol) solutio
Publikováno v:
International Journal of Pharmaceutics. 63:267-274
β-Cyclodextrin (β-CYD) has a hydrophobic cavity in which salbutamol may be clathrated. The ability of a guest molecule to penetrate the CYD host is determined by its size, stereochemistry and polarity. Intermolecular interactions such as the hydrop