Výsledky vyhledávání - "I.Victor Ekhato"

Structure−Activity Relationships of Pregabalin and Analogues That Target the α2-δ Protein

Autor: Thomas G. Heffner, Jack J. Kinsora, Jacob Bradley Schwarz, Ti Zhi-Su, David J. Wustrow, Leonard T. Meltzer, Thomas Richard Belliotti, Thomas Capiris, Andrew John Thorpe, Lawrence D. Wise, Mark L. Weber, Charles Taylor, Mark J. Field, Mark G. Vartanian, I.Victor Ekhato

Publikováno v: Journal of Medicinal Chemistry. 48:2294-2307

Pregabalin exhibits robust activity in preclinical assays indicative of potential antiepileptic, anxiolytic, and antihyperalgesic clinical efficacy. It binds with high affinity to the alpha(2)-delta subunit of voltage-gated calcium channels and is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05d681e9f725c4f7d0de7f09212832b
https://doi.org/10.1021/jm049762l

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Synthesis of 4-alkyl-pyrrolidine-3-carboxylic acid stereoisomers

Autor: I.Victor Ekhato, J. Ronald Rubin, David J. Wustrow, Rong Ling

Publikováno v: Tetrahedron. 57:6579-6588

All four possible stereoisomers of the 3-carboxyl-4-isopropyl-pyrrolidine (4) were prepared and their stereochemistry was assigned unambiguously.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be29a3257bf360c49c1c07940dd5ed04
https://doi.org/10.1016/s0040-4020(01)00549-x

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ChemInform Abstract: Synthesis of 4-Alkyl-pyrrolidine-3-carboxylic Acid Stereoisomers

Autor: J. Ronald Rubin, I.Victor Ekhato, David J. Wustrow, Rong Ling

Publikováno v: ChemInform. 32

All four possible stereoisomers of the 3-carboxyl-4-isopropyl-pyrrolidine (4) were prepared and their stereochemistry was assigned unambiguously.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb4a8f2aaf6a13842294db813a40f539
https://doi.org/10.1002/chin.200145218

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Norethindrone acetate (NA) and ethinyl estradiol (EE) related oxidative transformation products in stability samples of formulated drug product: synthesis of authentic references

Autor: Tim Hurley, Michael Lovdahl, Charles Colson, Yun Huang, Luyi Guo, I.Victor Ekhato, Scott Clipper, T.J Revitte

Publikováno v: Steroids. 67(3-4)

Preparative chemical methods for the synthesis of eight oxidative transformation products of ethinyl estradiol (EE) and norethindrone acetate (NA) are described. The prepared materials are useful as reference materials and standards for pharmaceutica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f1749b2e98ecd6e9c003d888e01d02
https://pubmed.ncbi.nlm.nih.gov/11856540

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