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pro vyhledávání: '"I.M. Wormstone"'
Akademický článek
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Cataract, a clouding of the lens, is the most common cause of blindness in the world. It has a marked impact on the wellbeing and productivity of individuals and has a major economic impact on healthcare providers. The only means of treating cataract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49cffe8729f47c5433d7cbb65b4d9d4
https://ueaeprints.uea.ac.uk/id/eprint/76999/
https://ueaeprints.uea.ac.uk/id/eprint/76999/
Autor:
Pankaj Gupta, Marcus A. Glomb, Cibin T. Raghavan, Mareen Smuda, Scott Howell, Dawn Smith, Ram H. Nagaraj, Annapurna Singh, Andrew J. O. Smith, I.M. Wormstone
Publikováno v:
Aging Cell
Summary Proteins in basement membrane (BM) are long‐lived and accumulate chemical modifications during aging; advanced glycation endproduct (AGE) formation is one such modification. The human lens capsule is a BM secreted by lens epithelial cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d679e540f20034697c3a7a09cc18ce
https://doi.org/10.1111/acel.12450
https://doi.org/10.1111/acel.12450
Autor:
Julie A. Eldred, I.M. Wormstone
Publikováno v:
Experimental Eye Research. 142:2-12
Millions of people worldwide are blinded due to cataract formation. At present the only means of treating a cataract is through surgical intervention. A modern cataract operation involves the creation of an opening in the anterior lens capsule to all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ecf8512ce5fd9f91d8471f57472031
https://doi.org/10.1016/j.exer.2015.04.021
https://doi.org/10.1016/j.exer.2015.04.021
Autor:
Peng Liu, Yongping Bao, Wei Wang, Zhigang Zhou, Andrew J. O. Smith, Yuqiong Chen, Richard P. Bowater, I.M. Wormstone
Publikováno v:
Nutrients; Volume 10; Issue 5; Pages: 585
Nutrients
Nutrients, Vol 10, Iss 5, p 585 (2018)
Nutrients
Nutrients, Vol 10, Iss 5, p 585 (2018)
Sulforaphane (SFN) exhibits chemopreventive effects through various mechanisms. However, few studies have focused on the bioactivities of its metabolites. Here, three metabolites derived from SFN were studied, known as sulforaphane glutathione, sulfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::442e9cd44354ee2d23cf25a5dcac5087
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences. 366:1301-1319
Fibrosis affects multiple organs and is associated with hyperproliferation, cell transdifferentiation, matrix modification and contraction. It is therefore essential to discover the key drivers of fibrotic events, which in turn will facilitate the de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e775d5fc27047a0e06cb6bf43a6f425
https://doi.org/10.1098/rstb.2010.0341
https://doi.org/10.1098/rstb.2010.0341
Autor:
I.M. Wormstone, Richard P. Bowater, Kamal Manzar, Andrew J. O. Smith, Simon Sidney Robert Ball
PURPOSE: Oxidative stress in the human lens leads to a wide range of damage including DNA strand breaks, which are likely to contribute to cataract formation. The protein Ku80 is a fundamental component of the nonhomologous end-joining pathway that r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14538f424fa3cdc06567c6d6832c4a8a
https://ueaeprints.uea.ac.uk/id/eprint/56750/
https://ueaeprints.uea.ac.uk/id/eprint/56750/
Publikováno v:
Lens Epithelium and Posterior Capsular Opacification ISBN: 9784431542995
Maintaining lens integrity is a lifetime ambition of the lens. However, if this integrity is breached through an altered ocular environment or physical disruption, such as cataract surgery, then fibrotic modifications to the lens can occur that are u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4c7ee85c4266280521548d133f5be1b
https://doi.org/10.1007/978-4-431-54300-8_8
https://doi.org/10.1007/978-4-431-54300-8_8
Publikováno v:
British Journal of Ophthalmology. 81:907-910
AIMS/BACKGROUND—Phacoemulsification is rapidly replacing conventional extracapsular cataract extraction (ECCE) as the method of choice for cataract surgery in the Western world. However, posterior capsule opacification (PCO) still remains the major
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bbb9a8368c2baab5e3180d240b0f7a6
https://doi.org/10.1136/bjo.81.10.907
https://doi.org/10.1136/bjo.81.10.907
Autor:
Hanruo Liu, Martin Lott, John R. Reddan, Yongping Bao, Andrew J. O. Smith, I.M. Wormstone, Richard P. Bowater
Publikováno v:
Investigative ophthalmologyvisual science. 54(8)
Protecting the lens against oxidative stress is of great importance in delaying the onset of cataract. Isothiocyanates, such as sulforaphane (SFN), are proposed to provide cytoprotection against oxidative stress. We therefore tested the ability of SF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5512162b9a266cd2ac811977d42a81a
https://pubmed.ncbi.nlm.nih.gov/23812493
https://pubmed.ncbi.nlm.nih.gov/23812493