Zobrazeno 1 - 10
of 157
pro vyhledávání: '"I.M. Macrae"'
Publikováno v:
Cerebrovascular Diseases; Vol 36
a Department of Neurology, Inserm U894, Centre Hospitalier Sainte Anne, Sorbonne Paris Cite, Paris , France; b Wellcome Surgical Institute & Glasgow Experimental MRI Centre, Institute of Neuroscience and Psychology, College of Medical, Veterinary and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf9eed441c7a82ef8ae51bdf02ea9c67
Autor:
Emily N.J. Ord, Hannah Martin, Jesse Dawson, I.M. Macrae, Christopher McCabe, James Cordiner, Emma Sigfridsson, Christopher R Breen, Josie C van Kralingen, Lorraine M. Work
Publikováno v:
Stroke. 47
Introduction: MicroRNA (miRNA) profiles are altered in patients with stroke. Recently, active inter-cellular transport of miRNAs in extracellular vesicles (EV), such as exosomes has been shown. We assessed whether miRNAs packaged in EVs differed in p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91f07e7b28bd04e366ef91365d386924
https://doi.org/10.1161/str.47.suppl_1.143
https://doi.org/10.1161/str.47.suppl_1.143
Autor:
I.M. Macrae
Publikováno v:
British Journal of Pharmacology. 164:1062-1078
This review describes the most commonly used rodent models and outcome measures in preclinical stroke research and discusses their strengths and limitations. Most models involve permanent or transient middle cerebral artery occlusion with therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d51076c7d53e3aa6a65d35736c6a04f
https://doi.org/10.1111/j.1476-5381.2011.01398.x
https://doi.org/10.1111/j.1476-5381.2011.01398.x
Publikováno v:
Clinical Science. 118:375-389
Evidence exists for the potential protective effects of circulating ovarian hormones in stroke, and oestrogen reduces brain damage in animal ischaemia models. However, a recent clinical trial indicated that HRT (hormone-replacement therapy) increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f41ac29abb3f57c5b24e7ad1d91041ec
https://doi.org/10.1042/cs20090018
https://doi.org/10.1042/cs20090018
Autor:
Lorraine M. Work, Catriona McDonald, Emily N.J. Ord, John D. McClure, I.M. Macrae, Christopher McCabe
Publikováno v:
Stroke. 46
MicroRNAs (miRNAs) are small non-coding RNA molecules (20 - 24 nucleotides) that inhibit mRNA translation. Demonstrated to have key roles in normal CNS development & function, they have also emerged to have effecter roles in the pathogenesis & endoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dacfdd1b3c9310152ec923b0fd8f3a27
https://doi.org/10.1161/str.46.suppl_1.wp248
https://doi.org/10.1161/str.46.suppl_1.wp248
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 287:H1501-H1504
The present study employs selective estrogen receptor (ER) agonists to determine whether 17β-estradiol-induced neuroprotection in global ischemia is receptor mediated and, if so, which subtype of receptor (ERα or ERβ) is predominantly responsible.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633f56cc38988c629ae7f6b2b5770962
https://doi.org/10.1152/ajpheart.00227.2004
https://doi.org/10.1152/ajpheart.00227.2004
Publikováno v:
Neuropathology and Applied Neurobiology. 30:683-691
GADD34 is a growth arrest and DNA damage inducible gene up-regulated in response to DNA damage, cell cycle arrest and apoptosis. It is thought that GADD34 may play a crucial role in cell survival in ischaemia. GADD34 expression was assessed immunohis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49a3050d244eef1b6fa5a487a518dc7d
https://doi.org/10.1111/j.1365-2990.2004.00584.x
https://doi.org/10.1111/j.1365-2990.2004.00584.x
Publikováno v:
European Journal of Neuroscience. 15:1929-1936
Cell cycle proteins play key roles in cell survival or death under pathological conditions. Expression of growth arrest and DNA damage-inducible protein, GADD34 and proliferating cell nuclear antigen (PCNA) have been investigated in the core and peri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcc74f99993efd57534f5cc34d917fda
https://doi.org/10.1046/j.1460-9568.2002.02025.x
https://doi.org/10.1046/j.1460-9568.2002.02025.x
Publikováno v:
Stroke. 32:2149-2154
Background and Purpose — The neuroprotective efficacy of an intravenous formulation of the antioxidant ebselen has been comprehensively assessed with specific regard to conventional quantitative histopathology, subcortical axonal damage, neurologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::875d78c8af4b2d0da4a5564c65737b62
https://doi.org/10.1161/hs0901.095725
https://doi.org/10.1161/hs0901.095725
Publikováno v:
European Journal of Neuroscience. 12:58-66
Cerebral blood flow (CBF) and cerebral autoregulation have been investigated 24 h after transient focal ischaemia in the rat. Cerebral blood flow was measured autoradiographically before and during a moderate hypotensive challenge, to test autoregula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32d3755cac24f0fb313d4704e7bc37a2
https://doi.org/10.1046/j.1460-9568.2000.00880.x
https://doi.org/10.1046/j.1460-9568.2000.00880.x