Výsledky vyhledávání - "I.K. O'Neill"

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Differences in N-acetylation genotypes between Caucasians and Black South Africans: implications for cancer prevention

Autor: I.K. O'Neill, William Moore, John H. Cummings, Theo Nell, H H Vorster, Sheila Bingham, Alexandre Loktionov, Steven P. Spencer

Publikováno v: Cancer Detection and Prevention. 26:15-22

Polymorphic N -acetyltransferase genes ( NAT1 and NAT2 ) determine rapid or slow acetylation phenotypes, which are believed to affect cancer risk related to environmental exposure. Black South Africans have a unique incidence pattern of environment-r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e2b49c4b63601fe023252de763e81c2
https://doi.org/10.1016/s0361-090x(02)00010-7

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Apolipoprotein E and methylenetetrahydrofolate reductase genetic polymorphisms in relation to other risk factors for cardiovascular disease in UK Caucasians and Black South Africans

Autor: Sheila Bingham, Shirley A. Runswick, Alexandre Loktionov, I.K. O'Neill, John H. Cummings, Theo Nell, H H Vorster

Publikováno v: Atherosclerosis. 145:125-135

Genetic polymorphisms for apolipoprotein E (apo E) and methylenetetrahydrofolate reductase (MTHFR) are believed to modulate risk of coronary heart disease (CHD) acting through regulation of lipid and homocysteine metabolism, respectively. The distrib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e5c70a704631c5f77e88a86463b168
https://doi.org/10.1016/s0021-9150(99)00022-2

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Gastrointestinal monitoring of DNA-damaging agents with magnetic microcapsules

Autor: Oonah Ridgway, Sheila Bingham, I.K. O'Neill, Anne Ellul

Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 290:127-138

Semi-permeable, magnetically recoverable, reactive microcapsules of several types were developed for gastrointestinal (GI) monitoring of several kinds of DNA-damaging agents in relation to (i) systematic dietary variations designed to discriminate th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b0e289ac5df24fb1f4c458c53070da
https://doi.org/10.1016/0027-5107(93)90040-m

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Magnetic microcapsule exploration in the gastrointestinal cavity of the origins of colorectal cancer-associated DNA-damaging agents in the human diet

Autor: Brigitte Incaurgarat, I.K. O'Neill, Sheila Bingham, Anne Ellul

Publikováno v: Environmental Health Perspectives

Magnetically recoverable, semipermeable microcapsules have been devised for covalent entrapment of reactive substances in the intestinal cavity to biomonitor potentially DNA-damaging agents and the effects of etiologically important components of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8b268e0c6668b262015b2727970be7
https://doi.org/10.1289/ehp.9399161

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Detection by 32P-postlablling of DNA adducts induced by free radicals and unsaturated aldehydes formed during the aerobic decomposition of fecapentaene-12

Autor: Andrew C. Povey, Vincent L. Wilson, Jay L. Zweier, Chris Harris, Periannan Kuppusamy, I.K. O'Neill

Publikováno v: Carcinogenesis. 13:395-401

Fecapentaene-12 (fec-12), excreted in human faeces, is genotoxic to human cells and a known animal carcinogen. The mechanism of its genotoxicity is unknown but may involve direct alkylation and/or free-radical generation. The formation of reactive sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17bc448840988c49121c9e8ff30aadae
https://doi.org/10.1093/carcin/13.3.395

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Entrapment by magnetic microcapsules of the protein pyrolysates IQ, PhIP and Glu-P-1, and alteration of IQ metabolite exposure within the rat gastrointestinal tract by risk-modulating components of the human diet

Autor: Anne Ellul, Hiroko Ohgaki, I.K. O'Neill, Robert J. Turesky

Publikováno v: Carcinogenesis. 13:2353-2359

The entrapment of heterocyclic aromatic amine gastrointestinal (GI) carcinogens (HAAs), by retrievable semipermeable magnetic polyethylenimine (PEI) microcapsules was investigated in vitro and in vivo as an approach for human biomonitoring. Previous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0113190886cda0aeaca04a0db777790a
https://doi.org/10.1093/carcin/13.12.2353

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Novel detection by magnetic microcapsules in the human gastrointestinal tract of cross-linking agents and diet-dependent reactive oxygen species

Autor: Sheila Bingham, Anne Ellul, John H. Cummings, I.K. O'Neill

Publikováno v: Carcinogenesis. 13:683-690

Semi-permeable magnetic microcapsules previously shown able to trap gastrointestinal carcinogens and containing polyethyleneimine (PEI) were covalently labelled with [14CH3], and administered for the first time to humans (six healthy volunteers, 1.3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c0f16dc6a45f6c725894603ae893a89
https://doi.org/10.1093/carcin/13.4.683

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Dietary fibre, fat and beef modulation of colonic nuclear aberrations and microcapsule-trapped gastrointestinal metabolites of benzo[a]pyrene-treated C57/B6 mice consuming human diets

Autor: I.K. O'Neill, F.Ei Ghissassi, M. Rojas-Moreno, M.T. Goldberg

Publikováno v: Carcinogenesis. 12:175-180

Male C57/B6 mice were adapted to human diets of British origin that had 3-fold differences in either dietary fibre, fat or beef protein within the normal human range, and were then treated p.o. with 200 mg/kg benzo[a]pyrene (B[a]P) to induce colonic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::786e1dc90c043cf557ed24616ba08976
https://doi.org/10.1093/carcin/12.2.175

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Copper phthalocyanine labelled magnnetic microcapsules: preparation, and binding properties in vitro and in vivo for mutagens having planar molecular structure

Autor: Andrew C. Povey, I.K. O'Neill

Publikováno v: Carcinogenesis. 11:1989-1993

Copper phthalocyanine tetrasulphonic acid (CPTS) functions were introduced into magnetic semi-permeable polyethyleneimine (PEI) microcapsules in order to create a recoverable scavenging system for trapping and biomonitoring, within the gastrointestin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ead4d50b2b451d874caabce89644fc
https://doi.org/10.1093/carcin/11.11.1989

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